ID   Q1PSH4_DANRE            Unreviewed;       588 AA.
AC   Q1PSH4;
DT   16-MAY-2006, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2006, sequence version 1.
DT   02-SEP-2026, entry version 85.
DE   SubName: Full=Disabled1 transcript variant 2 {ECO:0000313|EMBL:ABA54873.1};
GN   Name=dab1a {ECO:0000313|ZFIN:ZDB-GENE-060528-1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:ABA54873.1};
RN   [1] {ECO:0000313|EMBL:ABA54873.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mione M.C.;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABA54873.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16520940; DOI=10.1007/s00427-005-0052-5;
RA   Costagli A., Felice B., Guffanti A., Wilson S.W., Mione M.;
RT   "Identification of alternatively spliced dab1 isoforms in zebrafish.";
RL   Dev. Genes Evol. 216:291-299(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; DQ166811; ABA54873.1; -; mRNA.
DR   RefSeq; NP_001035775.2; NM_001040685.3.
DR   GeneID; 692351; -.
DR   KEGG; dre:692351; -.
DR   CTD; 692351; -.
DR   AGR; ZFIN:ZDB-GENE-060528-1; -.
DR   ZFIN; ZDB-GENE-060528-1; dab1a.
DR   OrthoDB; 10069833at2759; -.
DR   PhylomeDB; Q1PSH4; -.
DR   CDD; cd01215; PTB_Dab; 1.
DR   FunFam; 2.30.29.30:FF:000035; Disabled homolog 2 isoform 1; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR048559; DAB1/2_SBM.
DR   InterPro; IPR048561; Dab_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   PANTHER; PTHR47695:SF4; DISABLED HOMOLOG 1; 1.
DR   PANTHER; PTHR47695; PID DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF21792; DAB2_SBM; 1.
DR   Pfam; PF00640; PID; 1.
DR   SMART; SM00462; PTB; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01179; PID; 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   AlphaFoldDB; Q1PSH4; -.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          37..169
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          406..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          480..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..415
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        545..555
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        577..588
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   588 AA;  63743 MW;  DD01B46ED324D0D7 CRC64;
     MSTEAELQPD ARPSVRKDSK KRGQDRSEAA LIKRFKGDGV RYKAKLIGID EVTAARGDKL
     CQDSMMKLKG IAASARSKGE HKQKVFLTVS FGGIKIFDEK SGVLQHHHAV HEISYIAKDI
     TDHRAFGYVC GKEGNHRFVA IKTAQSAERV ILDLRDLFQL IYEIKQREEI EKKAQKDKQC
     EHAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPSEESIYQ VHYQGPYQPT KGGSLRRPKA
     TSSENINQLE LFGDMSTPPD ITSPSTPASP ANTLDPLLAH QTPSELFTPF NPASVPSGYV
     TMGAVPPAWA QQQFAAQAPL AFGVQSPVQV AQVLPGTQPL IWGQANLFPA TQQQWAAMAG
     AHFSPAAFMP AQTVGPLPAA MFQTLAPMAV PASCETPTAA MGGAVAGTSA STASSPQHGE
     RTLQRQAKMS KEMFKEFQMA KPPAMPARKG EQPSLSCTTD AFSSYFSRVG MAQDTDDCDD
     FDISQMNSHR HFTTPPQLTP PRPSAESPSS LIHASDPPTD DSFGEAEGSP SRSGEEDAAG
     DCPQSPGASE PQAEPESSET DSPQGKDPLY AQINKGKNLK HHGNSAQT
//