ID   Q1IS04_KORVE            Unreviewed;       794 AA.
AC   Q1IS04;
DT   13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2006, sequence version 1.
DT   02-SEP-2026, entry version 89.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:ABF40346.1};
GN   OrderedLocusNames=Acid345_1344 {ECO:0000313|EMBL:ABF40346.1};
OS   Koribacter versatilis (strain Ellin345).
OC   Bacteria; Pseudomonadati; Acidobacteriota; Terriglobia; Terriglobales;
OC   Candidatus Korobacteraceae; Candidatus Korobacter.
OX   NCBI_TaxID=204669 {ECO:0000313|EMBL:ABF40346.1, ECO:0000313|Proteomes:UP000002432};
RN   [1] {ECO:0000313|EMBL:ABF40346.1, ECO:0000313|Proteomes:UP000002432}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ellin345 {ECO:0000313|EMBL:ABF40346.1,
RC   ECO:0000313|Proteomes:UP000002432};
RX   PubMed=19201974; DOI=10.1128/AEM.02294-08;
RA   Ward N.L., Challacombe J.F., Janssen P.H., Henrissat B., Coutinho P.M.,
RA   Wu M., Xie G., Haft D.H., Sait M., Badger J., Barabote R.D., Bradley B.,
RA   Brettin T.S., Brinkac L.M., Bruce D., Creasy T., Daugherty S.C.,
RA   Davidsen T.M., DeBoy R.T., Detter J.C., Dodson R.J., Durkin A.S.,
RA   Ganapathy A., Gwinn-Giglio M., Han C.S., Khouri H., Kiss H., Kothari S.P.,
RA   Madupu R., Nelson K.E., Nelson W.C., Paulsen I., Penn K., Ren Q.,
RA   Rosovitz M.J., Selengut J.D., Shrivastava S., Sullivan S.A., Tapia R.,
RA   Thompson L.S., Watkins K.L., Yang Q., Yu C., Zafar N., Zhou L., Kuske C.R.;
RT   "Three genomes from the phylum Acidobacteria provide insight into the
RT   lifestyles of these microorganisms in soils.";
RL   Appl. Environ. Microbiol. 75:2046-2056(2009).
CC   -!- SUBCELLULAR LOCATION: Cell envelope {ECO:0000256|ARBA:ARBA00004196}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|PROSITE-ProRule:PRU00099}.
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DR   EMBL; CP000360; ABF40346.1; -; Genomic_DNA.
DR   RefSeq; WP_011522148.1; NC_008009.1.
DR   AlphaFoldDB; Q1IS04; -.
DR   STRING; 204669.Acid345_1344; -.
DR   EnsemblBacteria; ABF40346; ABF40346; Acid345_1344.
DR   KEGG; aba:Acid345_1344; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG4252; Bacteria.
DR   HOGENOM; CLU_000445_85_1_0; -.
DR   OrthoDB; 127505at2; -.
DR   Proteomes; UP000002432; Chromosome.
DR   GO; GO:0030313; C:cell envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-ARBA.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   FunFam; 3.30.70.1230:FF:000016; Adenylate/guanylate cyclase domain-containing protein; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR050697; Adenylyl/Guanylyl_Cyclase_3/4.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF1; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM01080; CHASE2; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Magnesium {ECO:0000256|PROSITE-ProRule:PRU00099};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00099};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002432};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        421..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        445..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        473..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          536..668
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   BINDING         541
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00099"
FT   BINDING         541
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00099"
FT   BINDING         542
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00099"
FT   BINDING         585
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00099"
FT   BINDING         585
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00099"
SQ   SEQUENCE   794 AA;  88367 MW;  9643F1B3EE0C6A5A CRC64;
     MMHDVKRIAK VVAVKAMRLF ALVPAWEVDA VIAVVVTAGA LALYLAVARY QERTGFSFIG
     NIELRSLDAR FEMRGSRQTD LDIVIIGVDE KTLRKTGYPI PRRAYASLVN KLASAGCKVI
     GFDLDFPTAE NNSALDVLNR LKGQAGAHTS PEFMSEIDNQ IASSDNDAAF GEAVAKAGNV
     ILGHVFLDSQ QKAQSLSSQE AEDYYKLLWD HPFPQTHPYP DGANFSPADA FMRQKGNTVF
     GVEPNIAKIA ERAKSIGYLD TVFDADGTIR RVPLLIYYKD LDFVPPIEIE MLRYLENISI
     DDSNAFIGQS GVHEIRLGAH AIHPAKDGTA LINYAGPYKT YPHYSLADVL TGEVSPATFH
     NKIVFVGPTA KGMGDMRITP FSTPEAAYMG VEIHANVLDN LLHSENPRRG FLKRGTREET
     VDLVVILLFG IGGGILFAKT PPLRAGIAAL SILGGFAAVA FIVFALFGMW IYVVIPAATV
     VIDYAAISSY RMIFEEREKR KVRKTFERYV APGVIKLIEE NPEKYFRTGG EMRELTVMFS
     DIRGFTEISE GLTPDELVHL LNRYLGDMTG VIFESLGTLD KYIGDAIMAF WGSPVPQSDH
     AYRACETALK MSVALNDLNQ RLTHEGKKTL KIGIGINSGQ MNVGNMGSEF RFAWTVMGDN
     VNLASRLEGQ TKAYKTMRLI TEFTYEEVKD QMVCRQLDVI RVQGKEKPVA IYELMDFVRS
     KDQYEDLLAH FNAARDAYIR QSWSEAITLF EGLLERYPED GPSIVLLDRC KEFRVSPPSR
     DWDGVYTTKK EAVH
//