ID   Q18CU9_CLOD6            Unreviewed;       102 AA.
AC   Q18CU9;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   02-SEP-2026, entry version 119.
DE   SubName: Full=PTS system, fructose-like IIB component {ECO:0000313|EMBL:CAJ67029.1};
DE            EC=2.7.1.69 {ECO:0000313|EMBL:CAJ67029.1};
GN   OrderedLocusNames=CD630_02080 {ECO:0000313|EMBL:CAJ67029.1};
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Bacillati; Bacillota; Clostridia; Peptostreptococcales;
OC   Peptostreptococcaceae; Clostridioides.
OX   NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ67029.1, ECO:0000313|Proteomes:UP000001978};
RN   [1] {ECO:0000313|EMBL:CAJ67029.1, ECO:0000313|Proteomes:UP000001978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630 {ECO:0000313|EMBL:CAJ67029.1,
RC   ECO:0000313|Proteomes:UP000001978};
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
RN   [2] {ECO:0000313|EMBL:CAJ67029.1, ECO:0000313|Proteomes:UP000001978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630 {ECO:0000313|EMBL:CAJ67029.1,
RC   ECO:0000313|Proteomes:UP000001978};
RX   PubMed=21349987; DOI=10.1099/jmm.0.030452-0;
RA   Monot M., Boursaux-Eude C., Thibonnier M., Vallenet D., Moszer I.,
RA   Medigue C., Martin-Verstraete I., Dupuy B.;
RT   "Reannotation of the genome sequence of Clostridium difficile strain 630.";
RL   J. Med. Microbiol. 60:1193-1199(2011).
RN   [3] {ECO:0000313|EMBL:CAJ67029.1, ECO:0000313|Proteomes:UP000001978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630 {ECO:0000313|EMBL:CAJ67029.1,
RC   ECO:0000313|Proteomes:UP000001978};
RX   PubMed=24568651; DOI=10.1186/1471-2164-15-160;
RA   Pettit L.J., Browne H.P., Yu L., Smits W.K., Fagan R.P., Barquist L.,
RA   Martin M.J., Goulding D., Duncan S.H., Flint H.J., Dougan G.,
RA   Choudhary J.S., Lawley T.D.;
RT   "Functional genomics reveals that Clostridium difficile Spo0A coordinates
RT   sporulation, virulence and metabolism.";
RL   BMC Genomics 15:160-160(2014).
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DR   EMBL; AM180355; CAJ67029.1; -; Genomic_DNA.
DR   RefSeq; WP_003435043.1; NC_009089.1.
DR   AlphaFoldDB; Q18CU9; -.
DR   STRING; 272563.CD630_02080; -.
DR   EnsemblBacteria; CAJ67029; CAJ67029; CD630_02080.
DR   GeneID; 66352757; -.
DR   KEGG; cdf:CD630_02080; -.
DR   KEGG; pdc:CDIF630_00330; -.
DR   PATRIC; fig|272563.120.peg.224; -.
DR   eggNOG; COG1445; Bacteria.
DR   OrthoDB; 9782569at2; -.
DR   PhylomeDB; Q18CU9; -.
DR   BioCyc; PDIF272563:G12WB-311-MONOMER; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR   GO; GO:0022877; F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IEA:InterPro.
DR   GO; GO:0090563; F:protein-phosphocysteine-sugar phosphotransferase activity; IEA:TreeGrafter.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro.
DR   CDD; cd05569; PTS_IIB_fructose; 1.
DR   FunFam; 3.40.50.2300:FF:000014; PTS system fructose-like transporter subunit IIB; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   InterPro; IPR050864; Bacterial_PTS_Sugar_Transport.
DR   InterPro; IPR036095; PTS_EIIB-like_sf.
DR   InterPro; IPR013011; PTS_EIIB_2.
DR   InterPro; IPR003501; PTS_EIIB_2/3.
DR   InterPro; IPR003353; PTS_IIB_fruc.
DR   NCBIfam; TIGR00829; FRU; 1.
DR   NCBIfam; NF007783; PRK10474.1; 1.
DR   PANTHER; PTHR30505; FRUCTOSE-LIKE PERMEASE; 1.
DR   PANTHER; PTHR30505:SF0; FRUCTOSE-LIKE PTS SYSTEM EIIBC COMPONENT-RELATED; 1.
DR   Pfam; PF02302; PTS_IIB; 1.
DR   SUPFAM; SSF52794; PTS system IIB component-like; 1.
DR   PROSITE; PS51099; PTS_EIIB_TYPE_2; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001978};
KW   Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAJ67029.1};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          1..99
FT                   /note="PTS EIIB type-2"
FT                   /evidence="ECO:0000259|PROSITE:PS51099"
FT   MOD_RES         9
FT                   /note="Phosphocysteine; by EIIA"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00422"
SQ   SEQUENCE   102 AA;  11266 MW;  4952B25116633CB2 CRC64;
     MKIVAVTSCP SGVAHTYMSA ESLELSAKKF GIEIKVETQG SSGIDNELSL KDIDEATCVI
     LTNDVEIRNM ERFKGKKVVR MSVSEIIKKS DALIKKIKDT FQ
//