ID   Q17FP7_AEDAE            Unreviewed;       471 AA.
AC   Q17FP7;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   02-SEP-2026, entry version 117.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AAEL003345-PA};
GN   Name=5577897 {ECO:0000313|EnsemblMetazoa:AAEL003345-PA};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota;
OC   Aparaglossata; Panorpida; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL003345-PA, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EnsemblMetazoa:AAEL003345-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL003345-PA};
RG   Aedes aegypti Genome Working Group (AGWG);
RA   Matthews B.J.;
RT   "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AAEL003345-PA}
RP   IDENTIFICATION.
RC   STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL003345-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000256|ARBA:ARBA00010755}.
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DR   AlphaFoldDB; Q17FP7; -.
DR   FunCoup; Q17FP7; 668.
DR   STRING; 7159.Q17FP7; -.
DR   PaxDb; 7159-Q17FP7; -.
DR   EnsemblMetazoa; AAEL003345-RA; AAEL003345-PA; AAEL003345.
DR   KEGG; aag:5577897; -.
DR   VEuPathDB; VectorBase:AAEL003345; -.
DR   eggNOG; KOG1316; Eukaryota.
DR   HOGENOM; CLU_027272_2_1_1; -.
DR   InParanoid; Q17FP7; -.
DR   OMA; DFAIEFC; -.
DR   OrthoDB; 2561043at2759; -.
DR   Proteomes; UP000008820; Chromosome 2.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   FunFam; 1.10.275.10:FF:000002; Argininosuccinate lyase; 1.
DR   FunFam; 1.10.40.30:FF:000001; Argininosuccinate lyase; 1.
DR   FunFam; 1.20.200.10:FF:000015; argininosuccinate lyase isoform X2; 1.
DR   Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR   Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR   Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   NCBIfam; TIGR00838; argH; 1.
DR   PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR   PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00145; ARGSUCLYASE.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; L-aspartase-like; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820}.
FT   DOMAIN          18..313
FT                   /note="Fumarate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00206"
FT   DOMAIN          376..443
FT                   /note="Argininosuccinate lyase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14698"
SQ   SEQUENCE   471 AA;  53322 MW;  CA5EA1BF550D89EB CRC64;
     MSSRQEEMVA TPFKLWGGRF SKGIDHVLSK VNNSLTVDKR LYSEDIDGSI AYAKSLTDAK
     LLTKSEFKVI CYGLETIRSE WEKGTIKLMP RDEDVHTVNE RRLIEIIGLQ IGGKLHTGRS
     RNEQVVVDMK LWMRNSVRDV MKQLAALIAG LNTVAERYID VLMPGYTHMQ KAQPVRFSHW
     ILSYAFYFKE DYHRFSEFLK RMNVLPLGSG ALAGNPFNIN RHQLAEDLGF NGVSYNSMNT
     VSDRDFVVEF NFLCTLAGVH LSRLAEDLIL FSTKEYNFLE LSEEYTTGSS LMPQKRNPDS
     LELIRGISGS VFGQHCGLLM TLKGLPSTYN KDLQCDKSGM FAVYDQILLS LTLATGVITT
     MKVDEERCLS ALSYDMLATD MAYYLVRKGI PFREAHHISG EVVAFSEKVK IPINKLTLED
     LKEISPCFDE TVSTLWNYEN SVEQYTVVGG TSMISVQEQI NLLKGFLSKC D
//