ID   Q13MP2_PARXL            Unreviewed;       558 AA.
AC   Q13MP2;
DT   22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT   22-AUG-2006, sequence version 1.
DT   02-SEP-2026, entry version 115.
DE   RecName: Full=ATP {ECO:0000256|PROSITE-ProRule:PRU10135};
DE            EC=6.5.1.1 {ECO:0000256|PROSITE-ProRule:PRU10135};
DE   AltName: Full=DNA ligase {ECO:0000256|PROSITE-ProRule:PRU10135};
GN   ORFNames=Bxe_B1315 {ECO:0000313|EMBL:ABE34647.1};
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC   Burkholderiales; Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265 {ECO:0000313|EMBL:ABE34647.1, ECO:0000313|Proteomes:UP000001817};
RN   [1] {ECO:0000313|EMBL:ABE34647.1, ECO:0000313|Proteomes:UP000001817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400 {ECO:0000313|EMBL:ABE34647.1,
RC   ECO:0000313|Proteomes:UP000001817};
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V.,
RA   Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J.,
RA   Parnell J.J., Ramette A., Richardson P., Seeger M., Smith D., Spilker T.,
RA   Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome
RT   shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003,
CC         ECO:0000256|PROSITE-ProRule:PRU10135};
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DR   EMBL; CP000271; ABE34647.1; -; Genomic_DNA.
DR   RefSeq; WP_011491968.1; NC_007952.1.
DR   AlphaFoldDB; Q13MP2; -.
DR   STRING; 266265.Bxe_B1315; -.
DR   KEGG; bxb:DR64_6622; -.
DR   KEGG; bxe:Bxe_B1315; -.
DR   PATRIC; fig|266265.5.peg.6445; -.
DR   eggNOG; COG1793; Bacteria.
DR   OrthoDB; 9767858at2; -.
DR   Proteomes; UP000001817; Chromosome 2.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd07897; Adenylation_DNA_ligase_Bac1; 1.
DR   CDD; cd07972; OBF_DNA_ligase_Arch_LigB; 1.
DR   Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR050191; ATP-dep_DNA_ligase.
DR   InterPro; IPR026333; ATP_dep_DNA_lig_pp_1105_fam.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   NCBIfam; TIGR04120; DNA_lig_bact; 1.
DR   NCBIfam; NF006701; PRK09247.1; 1.
DR   PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR   PANTHER; PTHR45674:SF13; DNA LIGASE-RELATED; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; ATP-dependent DNA ligase DNA-binding domain; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ABE34647.1};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001817}.
FT   DOMAIN          321..457
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
FT   ACT_SITE        244
FT                   /note="N6-AMP-lysine intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10135"
SQ   SEQUENCE   558 AA;  62132 MW;  ECC86F00BDE4722F CRC64;
     MKRFAALYTA LDATTSTHDK LEALTSYFAV AEPEDAAWAS YFLAGGKPRQ SVPTRLLSEI
     ARERAGLPAW LFEESYHAVG DLAETIAHIL PPAQRNSELG LTQWIEHRVL TLRGAAPEEL
     RTRLISYWDE LDWGGRFLLT KLIGGGFRVG VARQLVVRAL AEVAGVDHKR IAQRMVGWTD
     SQQKPDAARY LRLIAPEATS DDAQSGAPQH DSDLGLPYPF FLAHPLQADP ATLGDPSQWQ
     IEWKWDGIRA QLVKRGGRVW LWSRGEDLIT DRFPEVAALG EALPEGFVID GEILAWEPGA
     SAPLPFARLQ PRIARKTLTK KILADSPATL LAYDLLEAHG KDLRMTPLAE RRAQLDALAT
     TVDSTLARDL LRVSPLVSAP DWQALAALRD ESRARGVEGL MVKERESMYG VGRTKASGTW
     WKWKIDPYAV DAVLVYAQRG HGRRASLYTD FTFAVWDEAD GVRTLVPFAK AYSGLTDEEM
     RQVDAIVRKT TIEKFGPVRS VTPTLVFEIG FEGIQASPRH KSGVAVRFPR MLRWRTDKHI
     DDADTLPMLK GFIDDRAG
//