ID   Q0VCN4_BOVIN            Unreviewed;       476 AA.
AC   Q0VCN4; A0A3Q1M4Q8;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   02-SEP-2026, entry version 153.
DE   SubName: Full=Neurotrophic tyrosine kinase, receptor, type 2 {ECO:0000313|EMBL:AAI20086.1};
GN   Name=NTRK2 {ECO:0000313|EMBL:AAI20086.1, ECO:0000313|VGNC:VGNC:32310};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI20086.1};
RN   [1] {ECO:0000313|EMBL:AAI20086.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Hereford {ECO:0000313|EMBL:AAI20086.1};
RC   TISSUE=Fetal cerebellum {ECO:0000313|EMBL:AAI20086.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA   Holt R., Jones S.J., Marra M.A.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00114}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC120085; AAI20086.1; -; mRNA.
DR   RefSeq; NP_001068693.1; NM_001075225.2.
DR   AlphaFoldDB; Q0VCN4; -.
DR   SMR; Q0VCN4; -.
DR   GeneID; 505824; -.
DR   KEGG; bta:505824; -.
DR   CTD; 4915; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010647; -.
DR   VGNC; VGNC:32310; NTRK2.
DR   GeneTree; ENSGT00940000155181; -.
DR   HOGENOM; CLU_030959_1_0_1; -.
DR   OrthoDB; 10005095at2759; -.
DR   Bgee; ENSBTAG00000010647; Expressed in prefrontal cortex and 100 other cell types or tissues.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005030; F:neurotrophin receptor activity; IEA:InterPro.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
DR   GO; GO:0007169; P:cell surface receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   CDD; cd05855; IgI_TrkB_d5; 1.
DR   FunFam; 2.60.40.10:FF:000239; BDNF/NT-3 growth factors receptor; 1.
DR   FunFam; 3.80.10.10:FF:000048; BDNF/NT-3 growth factors receptor; 1.
DR   FunFam; 2.60.40.10:FF:000486; Tyrosine-protein kinase receptor; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR050467; LRFN.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   InterPro; IPR020777; NTRK.
DR   InterPro; IPR020455; NTRK2.
DR   InterPro; IPR031635; NTRK_LRRCT.
DR   PANTHER; PTHR45842:SF12; KEKKON 5, ISOFORM A; 1.
DR   PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF16920; LRRCT_2; 1.
DR   PRINTS; PR01939; NTKRECEPTOR.
DR   PRINTS; PR01941; NTKRECEPTOR2.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00013; LRRNT; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunoglobulin domain {ECO:0000256|PROSITE-ProRule:PRU00114};
KW   Kinase {ECO:0000313|EMBL:AAI20086.1};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Receptor {ECO:0000313|EMBL:AAI20086.1};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000313|EMBL:AAI20086.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..476
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014102423"
FT   TRANSMEM        430..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          197..282
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   476 AA;  52678 MW;  A2E4B9A96E6D6A97 CRC64;
     MSSWTRWHGP AMARLWGFCW LIVGFWRAAL ACPTSCKCSA SRIWCGDPSP GIVAFPKLEA
     TSADPENITE IYIANQKRLE IINEDDLEAY VGLKNLTIVD SGLKSVAHKA FLKNSNLQHI
     NFTRNKLTIL SRKHFRHLDL SELILVGNPF TCSCDVMWIK TLQETKPSPE TQDLYCLDEN
     SKNISLANLQ IPHCGLPSAN LAAPNLTVEE GKSITLSCTV AGDPVPNLYW DVGNLVSKHM
     NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
     WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYK
     LVAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNKSNGTLPT
     GVVDTGREHL SVYAVVVIAS VVGFCLLVML FLLKLARHSK FGMKGFVLFH KIPLDG
//