ID   Q0VAP4_HUMAN            Unreviewed;       265 AA.
AC   Q0VAP4;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   04-NOV-2026, entry version 120.
DE   SubName: Full=FANCA protein {ECO:0000313|EMBL:AAI20979.1};
GN   Name=FANCA {ECO:0000313|EMBL:AAI20979.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAI20979.1};
RN   [1] {ECO:0000313|EMBL:AAI20979.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC120978; AAI20979.1; -; mRNA.
DR   RefSeq; NP_001338759.1; NM_001351830.2.
DR   SMR; Q0VAP4; -.
DR   ProteomicsDB; 58805; -.
DR   GeneID; 2175; -.
DR   UCSC; uc010ciu.2; human.
DR   CTD; 2175; -.
DR   VEuPathDB; HostDB:ENSG00000187741; -.
DR   OrthoDB; 2287188at2759; -.
DR   ChiTaRS; FANCA; human.
DR   Bgee; ENSG00000187741; Expressed in right testis and 116 other cell types or tissues.
DR   InterPro; IPR003516; FANCA.
DR   InterPro; IPR031729; Fanconi_A_N.
DR   PANTHER; PTHR12047; FANCONI ANEMIA GROUP A PROTEIN; 1.
DR   PANTHER; PTHR12047:SF2; FANCONI ANEMIA GROUP A PROTEIN; 1.
DR   Pfam; PF15865; Fanconi_A_N; 1.
DR   GO; GO:0043240; C:Fanconi anaemia nuclear complex; IEA:InterPro.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0036297; P:interstrand cross-link repair; IEA:InterPro.
DR   Antibodypedia; 30916; 484 antibodies from 44 providers.
DR   AlphaFoldDB; Q0VAP4; -.
PE   2: Evidence at transcript level;
FT   DOMAIN          139..265
FT                   /note="Fanconi anaemia group A protein N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF15865"
SQ   SEQUENCE   265 AA;  29155 MW;  88838FC010CEDACF CRC64;
     MSDSWVPNSA SGQDPGGRRR AWAELLAGRV KREKYNPERA QKLKESAVRL LRSHQDLNAL
     LLEVEGPLCK KLSLSKVIDC DSSEAYANHS SSFIGSALQD QASRLGVPVG ILSAGMVASS
     VGQICTAPAE TSHPVLLTVE QRSSLLLEAV WHLHVQGIVS LQELLESHPD MHAVGSWLFR
     NLCCLCEQME ASCQHADVAR AMLSDFVQMF VLRGFQKNSD LRRTVEPEKM PQVTVDVLQR
     MLIFALDALA AGVQEESSTH KIVRC
//