ID   COMB_CLOPS              Reviewed;         247 AA.
AC   Q0SPZ8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   10-JUN-2026, entry version 90.
DE   RecName: Full=Probable 2-phosphosulfolactate phosphatase {ECO:0000255|HAMAP-Rule:MF_00490};
DE            EC=3.1.3.71 {ECO:0000255|HAMAP-Rule:MF_00490};
GN   Name=comB {ECO:0000255|HAMAP-Rule:MF_00490};
GN   OrderedLocusNames=CPR_2562;
OS   Clostridium perfringens (strain SM101 / Type A).
OC   Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=289380;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SM101 / Type A;
RX   PubMed=16825665; DOI=10.1101/gr.5238106;
RA   Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T.,
RA   Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H.,
RA   Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A.,
RA   Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D.,
RA   Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J.,
RA   Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B.,
RA   Paulsen I.T.;
RT   "Skewed genomic variability in strains of the toxigenic bacterial pathogen,
RT   Clostridium perfringens.";
RL   Genome Res. 16:1031-1040(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate +
CC         phosphate; Xref=Rhea:RHEA:23416, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15597, ChEBI:CHEBI:43474, ChEBI:CHEBI:58738; EC=3.1.3.71;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00490};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00490};
CC   -!- SIMILARITY: Belongs to the ComB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00490}.
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DR   EMBL; CP000312; ABG85733.1; -; Genomic_DNA.
DR   RefSeq; WP_011593242.1; NC_008262.1.
DR   AlphaFoldDB; Q0SPZ8; -.
DR   SMR; Q0SPZ8; -.
DR   KEGG; cpr:CPR_2562; -.
DR   GO; GO:0050532; F:2-phosphosulfolactate phosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0050545; F:sulfopyruvate decarboxylase activity; IEA:TreeGrafter.
DR   FunFam; 3.90.1560.10:FF:000001; Probable 2-phosphosulfolactate phosphatase; 1.
DR   Gene3D; 3.90.1560.10; ComB-like; 1.
DR   HAMAP; MF_00490; ComB; 1.
DR   InterPro; IPR005238; ComB-like.
DR   InterPro; IPR036702; ComB-like_sf.
DR   NCBIfam; NF002055; PRK00886.1-4; 1.
DR   PANTHER; PTHR37311; 2-PHOSPHOSULFOLACTATE PHOSPHATASE-RELATED; 1.
DR   PANTHER; PTHR37311:SF1; 2-PHOSPHOSULFOLACTATE PHOSPHATASE-RELATED; 1.
DR   Pfam; PF04029; 2-ph_phosp; 1.
DR   SUPFAM; SSF142823; ComB-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Magnesium.
FT   CHAIN           1..247
FT                   /note="Probable 2-phosphosulfolactate phosphatase"
FT                   /id="PRO_1000014464"
SQ   SEQUENCE   247 AA;  27290 MW;  DF5B4764B584C598 CRC64;
     MKIDVIISAD YIDSEALKGK IAVVIDMLRA TSVITTALYN GAKKVIPVVS VEEAFEKAKE
     LKSLGEEVLL GGERKALKID GFDFSNSPLE YKREIVEGKN VIMSTTNGTR ALNLCSKADK
     VIVASVLNGQ AVAKYLENEE KEIVFVNSGT NGEFSSDDFM CAGYIISELC KNKEVELTDI
     AKTAKYVYES SEGIEEFIKD AKHYNILKNL GLEEDLKYCS TKNLIDLVFE FKNGEIKTVE
     SGIKVKI
//