ID   Q0RPH9_FRAAA            Unreviewed;       318 AA.
AC   Q0RPH9;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   28-JAN-2026, entry version 109.
DE   SubName: Full=Dihydroorotate dehydrogenase A (Dihydroorotate oxidase A) (DHOdehase A) (DHODase A) (DHOD A) {ECO:0000313|EMBL:CAJ60552.1};
DE            EC=1.3.3.1 {ECO:0000313|EMBL:CAJ60552.1};
GN   OrderedLocusNames=FRAAL1902 {ECO:0000313|EMBL:CAJ60552.1};
OS   Frankia alni (strain DSM 45986 / CECT 9034 / ACN14a).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Frankiales;
OC   Frankiaceae; Frankia.
OX   NCBI_TaxID=326424 {ECO:0000313|EMBL:CAJ60552.1, ECO:0000313|Proteomes:UP000000657};
RN   [1] {ECO:0000313|EMBL:CAJ60552.1, ECO:0000313|Proteomes:UP000000657}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45986 / CECT 9034 / ACN14a
RC   {ECO:0000313|Proteomes:UP000000657};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA   Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA   Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA   Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA   Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA   Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA   Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|ARBA:ARBA00001917};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway.
CC       {ECO:0000256|ARBA:ARBA00004725}.
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DR   EMBL; CT573213; CAJ60552.1; -; Genomic_DNA.
DR   RefSeq; WP_011603079.1; NC_008278.1.
DR   AlphaFoldDB; Q0RPH9; -.
DR   STRING; 326424.FRAAL1902; -.
DR   KEGG; fal:FRAAL1902; -.
DR   eggNOG; COG0167; Bacteria.
DR   HOGENOM; CLU_042042_0_0_11; -.
DR   OrthoDB; 9794954at2; -.
DR   UniPathway; UPA00070; -.
DR   Proteomes; UP000000657; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004152; F:dihydroorotate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 2.30.26.10; Dihydroorotate Dehydrogenase A, chain A, domain 2; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR050074; DHO_dehydrogenase.
DR   InterPro; IPR023359; Dihydro_DH_chainA_dom2.
DR   InterPro; IPR012135; Dihydroorotate_DH_1_2.
DR   InterPro; IPR005720; Dihydroorotate_DH_cat.
DR   PANTHER; PTHR48109:SF1; DIHYDROOROTATE DEHYDROGENASE (FUMARATE); 1.
DR   PANTHER; PTHR48109; DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF01180; DHO_dh; 1.
DR   PIRSF; PIRSF000164; DHO_oxidase; 1.
DR   SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
PE   4: Predicted;
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   FMN {ECO:0000256|ARBA:ARBA00022643};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CAJ60552.1};
KW   Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000657}.
FT   DOMAIN          4..291
FT                   /note="Dihydroorotate dehydrogenase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01180"
SQ   SEQUENCE   318 AA;  32713 MW;  92495DFC2973D6EF CRC64;
     MSALAGVALE HPVMNAAGTC KSVEEVDSFA RSAVAAIVVG SITRQPRTGN TGNVYWPGRV
     YSINALGLPN RGLAYYGEHL PGMVERAHEA GKPLIVSVAG FDVGEYQEIA EVVADAGVDL
     VELNLACPNV WDGGAQKRIA CFDPGQTAAI CTAVGDALLA RAGGDQAGRV PYGVKISPFS
     DPAALAELAA VLAELAGRPG GPRFVTAVNT FPNALVVDAD HRPVVDVELA GMSGPALKPV
     GLGQVRQLRR LLPDTVDIVG VGGVGEGRDV AEYLRAGAAA VQAATAFWNR GEDPSVFGSI
     LASWIDAGGI DPVDSAIR
//