ID   Q0RCL3_FRAAA            Unreviewed;       588 AA.
AC   Q0RCL3;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   28-JAN-2026, entry version 102.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   OrderedLocusNames=FRAAL6188 {ECO:0000313|EMBL:CAJ64811.1};
OS   Frankia alni (strain DSM 45986 / CECT 9034 / ACN14a).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Frankiales;
OC   Frankiaceae; Frankia.
OX   NCBI_TaxID=326424 {ECO:0000313|EMBL:CAJ64811.1, ECO:0000313|Proteomes:UP000000657};
RN   [1] {ECO:0000313|EMBL:CAJ64811.1, ECO:0000313|Proteomes:UP000000657}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45986 / CECT 9034 / ACN14a
RC   {ECO:0000313|Proteomes:UP000000657};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA   Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA   Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA   Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA   Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA   Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA   Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr
CC       protein kinase family. NIMA subfamily. {ECO:0000256|ARBA:ARBA00010886}.
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DR   EMBL; CT573213; CAJ64811.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0RCL3; -.
DR   STRING; 326424.FRAAL6188; -.
DR   KEGG; fal:FRAAL6188; -.
DR   eggNOG; COG0515; Bacteria.
DR   HOGENOM; CLU_463643_0_0_11; -.
DR   Proteomes; UP000000657; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR050660; NEK_Ser/Thr_kinase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   PANTHER; PTHR43671; SERINE/THREONINE-PROTEIN KINASE NEK; 1.
DR   PANTHER; PTHR43671:SF13; SERINE_THREONINE-PROTEIN KINASE NEK2; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000000657};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          44..297
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          327..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          565..588
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..380
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        399..408
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        579..588
FT                   /note="Gly residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         72
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   588 AA;  59489 MW;  B3625B4BE806384D CRC64;
     MGWAGRTRPA RLLGRWLDRR GSRRSPMAQH DPLRDDDPRR VGPYTLLERV GAGGMGVVYL
     ARDSVGRRVA LKIPGSPGRA NQIPHSHERF VAEVATHRTL TSERVVRFLD ADVHGRPPWV
     ALEYVQGANL SQVVSETGVF SHRFLLALAA ELAEAVADIH AHGIVHRDLH PANVICLPNG
     IKVIDFGLAR IQADDESLIT KGPPIGVPAF MAPERFAGVV TRACDVFAWG CCVAYAAAGT
     PPFPNVAPRD AYAAVAGSPP VLTNLPGDLA DLVGWALAKK PEDRPTASRV AAELQGLGVP
     VTRPAARPWP AQALPLISQA VPGPAIAGTD GWIDGPHAGT ARSGSGDSGV VYRGPGGSGV
     HNSRIGDSEL GDSELGDSEL GDSRIGDSGL ITTPSQPSRP EHPNHREPAP IGPRGAGAVV
     AAVVAAAFCL LGLALTAGGY AAGDVTGPVC AGLVAAAAGV LALVRAGRRA GPVAPVAPAG
     AAGAAGAAGA AGAAGAGAPR PPVGVPAWFV PVTVAVGGVA GGVFGLLLAR GLWAGSPRAA
     AASELALACC FAAAFALYLR GSDPTRSAGH PTPRSGIRSP GGSGGTPS
//