ID   NTF3_PIG                Reviewed;         257 AA.
AC   Q06AV0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   02-SEP-2026, entry version 83.
DE   RecName: Full=Neurotrophin-3;
DE            Short=NT-3;
DE   Flags: Precursor;
GN   Name=NTF3;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Liu G.Y.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC       sensory neurons.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; DQ917625; ABI97170.1; -; mRNA.
DR   RefSeq; NP_001116624.1; NM_001123152.1.
DR   AlphaFoldDB; Q06AV0; -.
DR   SMR; Q06AV0; -.
DR   FunCoup; Q06AV0; 366.
DR   STRING; 9823.ENSSSCP00000062768; -.
DR   GlyCosmos; Q06AV0; 1 site, No reported glycans.
DR   GlyGen; Q06AV0; 1 site.
DR   PaxDb; 9823-ENSSSCP00000062768; -.
DR   GeneID; 100144493; -.
DR   KEGG; ssc:100144493; -.
DR   CTD; 4908; -.
DR   eggNOG; ENOG502R4FK; Eukaryota.
DR   InParanoid; Q06AV0; -.
DR   OrthoDB; 6491780at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0007169; P:cell surface receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR   GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR   GO; GO:0021675; P:nerve development; IBA:GO_Central.
DR   GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR   GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR   FunFam; 2.10.90.10:FF:000002; Brain-derived neurotrophic factor; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   InterPro; IPR015578; Neurotrophin-3.
DR   InterPro; IPR045815; NTF3_N.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR   Pfam; PF00243; NGF; 1.
DR   Pfam; PF19338; NTF3_N; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01914; NEUROTROPHN3.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..138
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000321575"
FT   CHAIN           139..257
FT                   /note="Neurotrophin-3"
FT                   /id="PRO_0000321576"
FT   REGION          61..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        131
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        152..217
FT                   /evidence="ECO:0000250"
FT   DISULFID        195..246
FT                   /evidence="ECO:0000250"
FT   DISULFID        205..248
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   257 AA;  29607 MW;  A71DCD1269EA0755 CRC64;
     MSILFYMIFL AYLRGIQGNS MDQRRLPEDS LNSLIIKLIQ ADILKNKLSK QMVDLQENYQ
     STLPKAEAPR EPERGEPAKS EFQPVTAVGP EWLRHHRRYN SPRVLLSDST PLEPPPLYLV
     EDYVGNPSVA NRTARRKRYA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK
     TGNSPVKQYF YETRCKEARP VKNGCRGIDD KHWNSQCKTS QTYFRALTSY NNKLVGWRWI
     RIDTSCVCAL SRKIGRT
//