ID   NPY1R_MOUSE             Reviewed;         382 AA.
AC   Q04573; Q61993;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   04-NOV-2026, entry version 191.
DE   RecName: Full=Neuropeptide Y receptor type 1;
DE            Short=NPY1-R;
GN   Name=Npy1r;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=1468559; DOI=10.1016/0014-5793(92)81490-d;
RA   Eva C., Oberto A., Sprengel R., Genazzani E.;
RT   "The murine NPY-1 receptor gene. Structure and delineation of tissue-
RT   specific expression.";
RL   FEBS Lett. 314:285-288(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=8530415; DOI=10.1074/jbc.270.50.30102;
RA   Nakamura M., Sakanaka C., Aoki Y., Ogasawara H., Tsuji T., Kodama H.,
RA   Matsumoto T., Shimizu T., Noma M.;
RT   "Identification of two isoforms of mouse neuropeptide Y-Y1 receptor
RT   generated by alternative splicing. Isolation, genomic structure, and
RT   functional expression of the receptors.";
RL   J. Biol. Chem. 270:30102-30110(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM NPY1-R ALPHA).
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=9623984; DOI=10.1038/nm0698-722;
RA   Pedrazzini T., Seydoux J., Kuenstner P., Aubert J.F., Grouzmann E.,
RA   Beermann F., Brunner H.R.;
RT   "Cardiovascular response, feeding behavior and locomotor activity in mice
RT   lacking the NPY Y1 receptor.";
RL   Nat. Med. 4:722-726(1998).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [6]
RP   FUNCTION.
RX   PubMed=21457230; DOI=10.1111/j.1476-5381.2011.01401.x;
RA   Tough I.R., Forbes S., Tolhurst R., Ellis M., Herzog H., Bornstein J.C.,
RA   Cox H.M.;
RT   "Endogenous peptide YY and neuropeptide Y inhibit colonic ion transport,
RT   contractility and transit differentially via Y(1) and Y(2) receptors.";
RL   Br. J. Pharmacol. 164:471-484(2011).
CC   -!- FUNCTION: Receptor for neuropeptide Y (NPY) and peptide YY (PYY). Can
CC       also bind with high affinity [Leu-31, Pro-34]NPY, an analog of NPY
CC       modified at residues 31 and 34 of the mature form, while having
CC       virtually no affinity for pancreatic polypeptide (PP/PPY) at
CC       physiological concentrations. NPY or PYY binding induces adenylate
CC       cyclase-inhibiting G protein-coupled receptor signaling, resulting in
CC       inhibition of cAMP production. Receptor activation by ligands also
CC       leads to an increase of intracellular Ca(2+) levels. As a receptor for
CC       NPY, it is involved in the regulation of eating behavior and NPY-
CC       induced stimulation of food intake (PubMed:9623984). Involved in the
CC       regulation of colonic antisecretory tone, and colonic contractility
CC       (PubMed:21457230). {ECO:0000250|UniProtKB:P25929,
CC       ECO:0000269|PubMed:21457230, ECO:0000269|PubMed:9623984}.
CC   -!- SUBUNIT: Interacts with GNAI1; the interaction stabilizes the receptor
CC       in the high affinity state for NPY. {ECO:0000250|UniProtKB:P25929}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P25929};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:P25929}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=NPY1-R alpha;
CC         IsoId=Q04573-1; Sequence=Displayed;
CC       Name=NPY1-R beta;
CC         IsoId=Q04573-2; Sequence=VSP_001912, VSP_001913;
CC   -!- TISSUE SPECIFICITY: The alpha form is highly expressed in the brain,
CC       heart, kidney, spleen, skeletal muscle, and lung, whereas the beta
CC       receptor mRNA was not detected in these tissues (PubMed:8530415).
CC       However, the beta form is expressed in mouse embryonic developmental
CC       stage (7 and 11 days), bone marrow cells and several hematopoietic cell
CC       lines (PubMed:8530415). {ECO:0000269|PubMed:8530415}.
CC   -!- DEVELOPMENTAL STAGE: The beta form is expressed in embryonic
CC       developmental stage (7 and 11 days). The beta form is an embryonic and
CC       a bone marrow form of NPY1-R, which decreases in the expression during
CC       development and differentiation. {ECO:0000269|PubMed:8530415}.
CC   -!- DISRUPTION PHENOTYPE: Knockout mice exhibit a lower daily food intake
CC       than wild-type animals, and a diminished refeeding response following a
CC       24-hour period of fasting. {ECO:0000269|PubMed:9623984}.
CC   -!- SIMILARITY: Belongs to the G protein-coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; Z18280; CAA79157.1; -; Genomic_DNA.
DR   EMBL; Z18281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; D63818; BAA09887.1; -; mRNA.
DR   EMBL; D63819; BAA09888.1; -; mRNA.
DR   EMBL; BC051420; AAH51420.1; -; mRNA.
DR   CCDS; CCDS22336.1; -. [Q04573-1]
DR   PIR; S27388; S27388.
DR   RefSeq; NP_001345884.1; NM_001358955.1. [Q04573-1]
DR   RefSeq; NP_035064.1; NM_010934.4. [Q04573-1]
DR   RefSeq; XP_006509657.1; XM_006509594.5. [Q04573-1]
DR   RefSeq; XP_006509658.1; XM_006509595.5. [Q04573-1]
DR   RefSeq; XP_036009704.1; XM_036153811.1. [Q04573-1]
DR   RefSeq; XP_036009705.1; XM_036153812.1. [Q04573-1]
DR   AlphaFoldDB; Q04573; -.
DR   SMR; Q04573; -.
DR   CORUM; Q04573; -.
DR   FunCoup; Q04573; 760.
DR   STRING; 10090.ENSMUSP00000045530; -.
DR   BindingDB; Q04573; -.
DR   ChEMBL; CHEMBL4739851; -.
DR   GuidetoPHARMACOLOGY; 305; -.
DR   GlyCosmos; Q04573; 3 sites, No reported glycans.
DR   GlyGen; Q04573; 3 sites, 1 N-linked glycan (1 site).
DR   iPTMnet; Q04573; -.
DR   PhosphoSitePlus; Q04573; -.
DR   PaxDb; 10090-ENSMUSP00000045530; -.
DR   ProteomicsDB; 293883; -. [Q04573-1]
DR   Antibodypedia; 16963; 464 antibodies from 40 providers.
DR   DNASU; 18166; -.
DR   Ensembl; ENSMPUT00000001894; ENSMPUP00000001858; ENSMPUG00000001873.
DR   Ensembl; ENSMUST00000039303.7; ENSMUSP00000045530.6; ENSMUSG00000036437.7. [Q04573-1]
DR   Ensembl; ENSMUST00000212588.2; ENSMUSP00000148417.2; ENSMUSG00000036437.7. [Q04573-1]
DR   GeneID; 18166; -.
DR   KEGG; mmu:18166; -.
DR   UCSC; uc009lvt.2; mouse. [Q04573-1]
DR   AGR; MGI:104963; -.
DR   CTD; 4886; -.
DR   MGI; MGI:104963; Npy1r.
DR   VEuPathDB; HostDB:ENSMUSG00000036437; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000160268; -.
DR   HOGENOM; CLU_009579_6_1_1; -.
DR   InParanoid; Q04573; -.
DR   OMA; AENHSIY; -.
DR   OrthoDB; 9046662at2759; -.
DR   PhylomeDB; Q04573; -.
DR   Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   BioGRID-ORCS; 18166; 3 hits in 76 CRISPR screens.
DR   PRO; PR:Q04573; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q04573; protein.
DR   Bgee; ENSMUSG00000036437; Expressed in ascending aorta and 107 other cell types or tissues.
DR   ExpressionAtlas; Q04573; baseline and differential.
DR   GO; GO:0030424; C:axon; ISO:GO_Central.
DR   GO; GO:0098978; C:glutamatergic synapse; ISO:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0098992; C:neuronal dense core vesicle; ISO:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISO:GO_Central.
DR   GO; GO:0042734; C:presynaptic membrane; ISO:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; ISO:GO_Central.
DR   GO; GO:0008188; F:neuropeptide receptor activity; ISO:GO_Central.
DR   GO; GO:0004983; F:neuropeptide Y receptor activity; IDA:MGI.
DR   GO; GO:0001602; F:pancreatic polypeptide receptor activity; IDA:MGI.
DR   GO; GO:0001601; F:peptide YY receptor activity; IDA:MGI.
DR   GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; ISO:GO_Central.
DR   GO; GO:0007631; P:feeding behavior; IMP:MGI.
DR   GO; GO:0006006; P:glucose metabolic process; IMP:MGI.
DR   GO; GO:0007626; P:locomotory behavior; IMP:MGI.
DR   GO; GO:0002865; P:negative regulation of acute inflammatory response to antigenic stimulus; ISO:GO_Central.
DR   GO; GO:0051481; P:negative regulation of cytosolic calcium ion concentration; ISO:GO_Central.
DR   GO; GO:0046888; P:negative regulation of hormone secretion; ISO:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR   GO; GO:0003151; P:outflow tract morphogenesis; ISO:GO_Central.
DR   GO; GO:0030432; P:peristalsis; ISO:GO_Central.
DR   GO; GO:0045542; P:positive regulation of cholesterol biosynthetic process; ISO:GO_Central.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; ISO:GO_Central.
DR   GO; GO:0008217; P:regulation of blood pressure; IMP:MGI.
DR   GO; GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.
DR   GO; GO:0099509; P:regulation of presynaptic cytosolic calcium ion concentration; ISO:GO_Central.
DR   GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; ISO:GO_Central.
DR   GO; GO:0043278; P:response to morphine; ISO:GO_Central.
DR   GO; GO:0019233; P:sensory perception of pain; IMP:MGI.
DR   GO; GO:0099538; P:synaptic signaling via neuropeptide; ISO:GO_Central.
DR   CDD; cd15395; 7tmA_NPY1R; 1.
DR   FunFam; 1.20.1070.10:FF:000062; Neuropeptide Y receptor type 1; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000351; NPY1_rcpt.
DR   InterPro; IPR000611; NPY_rcpt.
DR   PANTHER; PTHR24235; NEUROPEPTIDE Y RECEPTOR; 1.
DR   PANTHER; PTHR24235:SF24; NEUROPEPTIDE Y RECEPTOR TYPE 1; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01013; NRPEPTIDEY1R.
DR   PRINTS; PR01012; NRPEPTIDEYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Disulfide bond;
KW   G protein-coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate;
KW   Phosphoprotein; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..382
FT                   /note="Neuropeptide Y receptor type 1"
FT                   /id="PRO_0000069921"
FT   TOPO_DOM        1..36
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        37..62
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250|UniProtKB:P25929"
FT   TOPO_DOM        63..75
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        76..98
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250|UniProtKB:P25929"
FT   TOPO_DOM        99..109
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        110..135
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250|UniProtKB:P25929"
FT   TOPO_DOM        136..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        154..174
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250|UniProtKB:P25929"
FT   TOPO_DOM        175..207
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        208..232
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250|UniProtKB:P25929"
FT   TOPO_DOM        233..261
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        262..284
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000250|UniProtKB:P25929"
FT   TOPO_DOM        285..298
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        299..322
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000250|UniProtKB:P25929"
FT   TOPO_DOM        323..382
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   MOD_RES         367
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P21555"
FT   MOD_RES         375
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   LIPID           337
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        2
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        11
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        17
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        112..197
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VAR_SEQ         304..307
FT                   /note="CHLT -> LNMN (in isoform NPY1-R beta)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_001912"
FT   VAR_SEQ         308..382
FT                   /note="Missing (in isoform NPY1-R beta)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_001913"
SQ   SEQUENCE   382 AA;  44015 MW;  CDCCF93E3ABB4D70 CRC64;
     MNSTLFSKVE NHSIHYNASE NSPLLAFEND DCHLPLAVIF TLALAYGAVI ILGVSGNLAL
     IIIILKQKEM RNVTNILIVN LSFSDLLVAV MCLPFTFVYT LMDHWVFGET MCKLNPFVQC
     VSITVSIFSL VLIAVERHQL IINPRGWRPN NRHAYIGITV IWVLAVASSL PFVIYQILTD
     EPFQNVSLAA FKDKYVCFDK FPSDSHRLSY TTLLLVLQYF GPLCFIFICY FKIYIRLKRR
     NNMMDKIRDS KYRSSETKRI NIMLLSIVVA FAVCWLPLTI FNTVFDWNHQ IIATCNHNLL
     FLLCHLTAMI STCVNPIFYG FLNKNFQRDL QFFFNFCDFR SRDDDYETIA MSTMHTDVSK
     TSLKQASPVA FKKISMNDNE KV
//