ID   LIC4_YEAST              Reviewed;         294 AA.
AC   Q04005; D6VSG8; Q6Q540;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-SEP-2026, entry version 138.
DE   RecName: Full=Protein ATC1/LIC4;
DE   AltName: Full=AIP3 complex protein 1;
DE   AltName: Full=Lithium comvertas protein 4;
GN   Name=ATC1; Synonyms=LIC4; OrderedLocusNames=YDR184C;
GN   ORFNames=YD9395.18c;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867; DOI=10.1038/387s075;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA   Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA   Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA   Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA   Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA   Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA   Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA   Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA   Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA   Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA   Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA   Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA   Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA   Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA   Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA   Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA   Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA   Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA   Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA   Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND PHOSPHORYLATION.
RX   PubMed=10102375; DOI=10.1007/s004380050980;
RA   Hemenway C.S., Heitman J.;
RT   "Lic4, a nuclear phosphoprotein that cooperates with calcineurin to
RT   regulate cation homeostasis in Saccharomyces cerevisiae.";
RL   Mol. Gen. Genet. 261:388-401(1999).
RN   [5]
RP   FUNCTION.
RX   PubMed=11065362; DOI=10.1099/00221287-146-11-2833;
RA   Freedman T., Porter A., Haarer B.;
RT   "Mutational and hyperexpression-induced disruption of bipolar budding in
RT   yeast.";
RL   Microbiology 146:2833-2843(2000).
RN   [6]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [7]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [8]
RP   FUNCTION.
RX   PubMed=14975746; DOI=10.1016/j.bbrc.2004.01.099;
RA   Munson A.M., Love S.L., Shu J., Palanivel V.R., Rosenwald A.G.;
RT   "ARL1 participates with ATC1/LIC4 to regulate responses of yeast cells to
RT   ions.";
RL   Biochem. Biophys. Res. Commun. 315:617-623(2004).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA   Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT   "A multidimensional chromatography technology for in-depth phosphoproteome
RT   analysis.";
RL   Mol. Cell. Proteomics 7:1389-1396(2008).
CC   -!- FUNCTION: Involved in cation homeostasis and in the regulation of the
CC       cation stress signaling cascades. Also involved in bipolar budding.
CC       {ECO:0000269|PubMed:10102375, ECO:0000269|PubMed:11065362,
CC       ECO:0000269|PubMed:14975746}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The nuclear location is
CC       modulated by calcineurin.
CC   -!- MISCELLANEOUS: Present with 846 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; Z46727; CAA86691.1; -; Genomic_DNA.
DR   EMBL; AY558576; AAS56902.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA12028.1; -; Genomic_DNA.
DR   PIR; S49781; S49781.
DR   RefSeq; NP_010470.1; NM_001180492.1.
DR   AlphaFoldDB; Q04005; -.
DR   SMR; Q04005; -.
DR   BioGRID; 32238; 136.
DR   DIP; DIP-832N; -.
DR   FunCoup; Q04005; 128.
DR   IntAct; Q04005; 4.
DR   STRING; 4932.YDR184C; -.
DR   GlyGen; Q04005; 3 sites, 1 O-linked glycan (3 sites).
DR   iPTMnet; Q04005; -.
DR   PaxDb; 4932-YDR184C; -.
DR   PeptideAtlas; Q04005; -.
DR   EnsemblFungi; YDR184C_mRNA; YDR184C; YDR184C.
DR   GeneID; 851765; -.
DR   KEGG; sce:YDR184C; -.
DR   AGR; SGD:S000002592; -.
DR   SGD; S000002592; ATC1.
DR   VEuPathDB; FungiDB:YDR184C; -.
DR   eggNOG; ENOG502S4IW; Eukaryota.
DR   HOGENOM; CLU_039078_0_0_1; -.
DR   InParanoid; Q04005; -.
DR   OMA; YARSCVE; -.
DR   OrthoDB; 4070577at2759; -.
DR   BioCyc; YEAST:G3O-29773-MONOMER; -.
DR   BioGRID-ORCS; 851765; 2 hits in 10 CRISPR screens.
DR   PRO; PR:Q04005; -.
DR   Proteomes; UP000002311; Chromosome IV.
DR   RNAct; Q04005; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0007121; P:bipolar cellular bud site selection; IMP:SGD.
DR   GO; GO:0030003; P:intracellular monoatomic cation homeostasis; IMP:SGD.
DR   InterPro; IPR063779; LIC4_C.
DR   Pfam; PF28633; LIC4_C; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..294
FT                   /note="Protein ATC1/LIC4"
FT                   /id="PRO_0000076239"
FT   REGION          114..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..145
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..175
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        204
FT                   /note="S -> P (in Ref. 3; AAS56902)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   294 AA;  33114 MW;  4D33DCBEF0BFDF91 CRC64;
     MNTNQSNPNT DLTDDANIEH TLHRLLTQAN NHFDDTVKID GQSLDLGKDL EQVMMDNLDC
     TDIFDSDIAS QKHLTLESLF NDEHNTDSST LLEMQRSAND SLVGIDLDRH KKGYTGKASL
     DKSTNQNNVH KPDKEQKNYK IDKPTIKKKK SLLKTTNEPM LSPASLSPSS SLASSDANES
     HLKIESMITD ITSKIDSARQ DIVSATKPAK FTNEFTISQI SEMKARIINT HKLLLNFNFI
     KEGYARSCIQ LKKSMDSLKD SEIHRAHLLV ENDDLKQQIL ELTQKLNEKS SKES
//