ID   ADA1D_MOUSE             Reviewed;         562 AA.
AC   P97714; Q61619;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   10-JUN-2026, entry version 161.
DE   RecName: Full=Alpha-1D adrenergic receptor {ECO:0000303|PubMed:7595531};
DE   AltName: Full=Alpha-1A adrenergic receptor {ECO:0000250|UniProtKB:P25100};
DE   AltName: Full=Alpha-1D adrenoreceptor;
DE            Short=Alpha-1D adrenoceptor {ECO:0000250|UniProtKB:O02666};
GN   Name=Adra1d {ECO:0000312|MGI:MGI:106673}; Synonyms=Adra1a, Gpcr8;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=7595531; DOI=10.1046/j.1471-4159.1995.65062387.x;
RA   Alonso-Llamazares A., Zamanillo D., Casanova E., Ovalle S., Calvo P.,
RA   Chinchetru M.A.;
RT   "Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution
RT   of three alpha 1-adrenergic receptor subtypes in mouse.";
RL   J. Neurochem. 65:2387-2392(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10622215; DOI=10.1254/jjp.81.271;
RA   Arai K., Tanoue A., Goda N., Takeda M., Takahashi K., Tsujimoto G.;
RT   "Characterization of the mouse alpha1D-adrenergic receptor gene.";
RL   Jpn. J. Pharmacol. 81:271-278(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 190-350.
RC   TISSUE=Testis;
RX   PubMed=8288218; DOI=10.1006/geno.1993.1452;
RA   Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I.,
RA   Copeland N.G., Jenkins N.A.;
RT   "Identification, chromosomal location, and genome organization of mammalian
RT   G-protein-coupled receptors.";
RL   Genomics 18:175-184(1993).
RN   [4]
RP   PALMITOYLATION BY ZDHHC21.
RX   PubMed=26715683; DOI=10.1161/atvbaha.115.306942;
RA   Marin E.P., Jozsef L., Di Lorenzo A., Held K.F., Luciano A.K., Melendez J.,
RA   Milstone L.M., Velazquez H., Sessa W.C.;
RT   "The Protein Acyl Transferase ZDHHC21 Modulates alpha1 Adrenergic Receptor
RT   Function and Regulates Hemodynamics.";
RL   Arterioscler. Thromb. Vasc. Biol. 36:370-379(2016).
CC   -!- FUNCTION: Alpha-1 adrenergic receptors are G protein-coupled receptors
CC       for catecholamines that signal through the G(q) family of G proteins,
CC       including G(q) and G(11). Upon activation, they stimulate the
CC       phosphatidylinositol-calcium second messenger pathway, leading to
CC       calcium release from intracellular stores and activation of protein
CC       kinase C (By similarity). ADRA1D binds the catecholamine ligands
CC       norepinephrine and epinephrine (By similarity).
CC       {ECO:0000250|UniProtKB:P25100}.
CC   -!- SUBUNIT: Interacts with FLNA (via filamin repeat 21); increases PKA-
CC       mediated phosphorylation of FLNA. {ECO:0000250|UniProtKB:P25100}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- PTM: Palmitoylated (PubMed:26715683). Palmitoylation by ZDHHC21 may
CC       increase the expression of the receptor and regulate downstream
CC       signaling (PubMed:26715683). {ECO:0000269|PubMed:26715683}.
CC   -!- SIMILARITY: Belongs to the G protein-coupled receptor 1 family.
CC       Adrenergic receptor subfamily. ADRA1D sub-subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; S80044; AAB47042.1; -; mRNA.
DR   EMBL; AB030642; BAA90312.1; -; Genomic_DNA.
DR   EMBL; L20333; AAA16854.1; -; mRNA.
DR   PIR; D48909; D48909.
DR   AlphaFoldDB; P97714; -.
DR   SMR; P97714; -.
DR   CORUM; P97714; -.
DR   FunCoup; P97714; 491.
DR   STRING; 10090.ENSMUSP00000099473; -.
DR   BindingDB; P97714; -.
DR   ChEMBL; CHEMBL2130; -.
DR   GlyCosmos; P97714; 2 sites, No reported glycans.
DR   GlyGen; P97714; 2 sites.
DR   PhosphoSitePlus; P97714; -.
DR   PaxDb; 10090-ENSMUSP00000099473; -.
DR   AGR; MGI:106673; -.
DR   MGI; MGI:106673; Adra1d.
DR   InParanoid; P97714; -.
DR   Reactome; R-MMU-390696; Adrenoceptors.
DR   Reactome; R-MMU-416476; G alpha (q) signalling events.
DR   Reactome; R-MMU-416482; G alpha (12/13) signalling events.
DR   PRO; PR:P97714; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P97714; protein.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004937; F:alpha1-adrenergic receptor activity; IDA:MGI.
DR   GO; GO:0042802; F:identical protein binding; ISO:GO_Central.
DR   GO; GO:0071880; P:adenylate cyclase-activating adrenergic receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   GO; GO:0001986; P:negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure; IMP:MGI.
DR   GO; GO:0150099; P:neuron-glial cell signaling; IGI:ARUK-UCL.
DR   GO; GO:0001994; P:norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; IMP:MGI.
DR   GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IBA:GO_Central.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; ISO:GO_Central.
DR   GO; GO:0008217; P:regulation of blood pressure; IMP:MGI.
DR   FunFam; 1.20.1070.10:FF:000208; Alpha-1D adrenergic receptor; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR002233; ADR_fam.
DR   InterPro; IPR000363; ADRA1D_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24248:SF14; ALPHA-1D ADRENERGIC RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR01103; ADRENERGICR.
DR   PRINTS; PR00240; ADRENRGCA1DR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; G protein-coupled receptor; Glycoprotein; Lipoprotein;
KW   Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..562
FT                   /note="Alpha-1D adrenergic receptor"
FT                   /id="PRO_0000069074"
FT   TOPO_DOM        1..90
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        91..115
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        116..127
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        128..153
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        154..163
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        164..186
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        187..207
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        208..232
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        233..245
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        246..269
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        270..342
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        343..367
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        368..374
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        375..399
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        400..562
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   REGION          13..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          50..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..44
FT                   /note="Gly residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         170
FT                   /ligand="(R)-adrenaline"
FT                   /ligand_id="ChEBI:CHEBI:71406"
FT                   /evidence="ECO:0000250|UniProtKB:P35348"
FT   BINDING         252
FT                   /ligand="(R)-adrenaline"
FT                   /ligand_id="ChEBI:CHEBI:71406"
FT                   /evidence="ECO:0000250|UniProtKB:P35348"
FT   LIPID           413
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        76
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        330
FT                   /note="R -> G (in Ref. 3; AAA16854)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   562 AA;  59858 MW;  6CF15515B5F7FA47 CRC64;
     MTFRDILSVT FEGPRASSST GGSGAGGGAG TVGPEGPAVG GVPGATGGSA VVGTGSGEDN
     QSSTAEAGAA ASGEVNGSAA VGGLVVSAQG VGVGVFLAAF ILTAVAGNLL VILSVACNRH
     LQTVTNYFIV NLAVADLLLS AAVLPFSATM EVLGFWPFGR TFCDVWAAVD VLCCTASILS
     LCTISVDRYV GVRHSLKYPA IMTERKAAAI LALLWAVALV VSVGPLLGWK EPVPPDERFC
     GITEEVGYAI FSSVCSFYLP MAVIVVMYCR VYVVARSTTR SLEAGIKREP GKASEVVLRI
     HCRGAATSAK GNPGTQSSKG HTLRSSLSVR LLKFSREKKA AKTLAIVVGV FVLCWFPFFF
     VLPLGSLFPQ LKPSEGVFKV IFWLGYFNSC VNPLIYPCSS REFKRAFLRL LRCQCRRRRR
     RLWPSLRPPL ASLDRRPALR LCPQPAHRTP RGSPSPHCTP RPGLRRHAGG AGFGLRPSKA
     SLRLREWRLL GPLQRPTTQL RAKVSSLSHK FRSGGARRAE TACALRSEVE AVSLNVPQDG
     AEAVICQAYE PGDLSNLRET DI
//