ID   KC1A_RAT                Reviewed;         353 AA.
AC   P97633-2;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   04-NOV-2026, entry version 179.
DE   RecName: Full=Isoform 2 of Casein kinase I isoform alpha;
DE            Short=CKI-alpha;
DE            EC=2.7.11.1;
DE   AltName: Full=CK1;
GN   Name=Csnk1a1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=Sprague-Dawley;
RX   PubMed=8973207; DOI=10.1021/bi9614444;
RA   Zhang J., Gross S.D., Schroeder M.D., Anderson R.A.;
RT   "Casein kinase I alpha and alpha L: alternative splicing-generated kinases
RT   exhibit different catalytic properties.";
RL   Biochemistry 35:16319-16327(1996).
RN   [2]
RP   ROLE IN WNT SIGNALING.
RX   PubMed=11955436; DOI=10.1016/s0092-8674(02)00685-2;
RA   Liu C., Li Y., Semenov M., Han C., Baeg G.-H., Tan Y., Zhang Z., Lin X.,
RA   He X.;
RT   "Control of beta-catenin phosphorylation/degradation by a dual-kinase
RT   mechanism.";
RL   Cell 108:837-847(2002).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=Isoforms exhibit differences in binding and activity toward
CC         common CKI substrates.;
CC       Name=1; Synonyms=CKI-alpha;
CC         IsoId=P97633-1; Sequence=Displayed;
CC       Name=2; Synonyms=CKI-alpha-L;
CC         IsoId=P97633-2; Sequence=VSP_004745;
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DR   Proteomes; UP000002494; Unplaced.
PE   4: Predicted;
FT   MOD_RES         156
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   353 AA;  40514 MW;  2E25B495A5307919 CRC64;
     MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ KARHPQLLYE
     SKLYKILQGG VGIPHIRWYG QGKDYNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM
     ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC NKCLESPVGK RKRSMTVSPS QDPSFSGLNQ
     LFLIDFGLAK KYRDNRTRQH IPYREDKNLT GTARYASINA HLGIEQSRRD DMESLGYVLM
     YFNRTSLPWQ GLKAATKKQK YEKISEKKMS TPVEVLCKGF PAEFAMYLNY CRGLRFEEAP
     DYMYLRQLFR ILFRTLNHQY DYTFDWTMLK QKAAQQAASS SGQGQQAQTP TGF
//