ID   P96830_MYCTO            Unreviewed;       276 AA.
AC   P96830; F2GLV1; Q7DAD4;
DT   01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1998, sequence version 2.
DT   28-JAN-2026, entry version 157.
DE   RecName: Full=Tyrosine specific protein phosphatases domain-containing protein {ECO:0000259|PROSITE:PS50056};
GN   OrderedLocusNames=MT0162 {ECO:0000313|EMBL:AAK44386.1};
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
OC   Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331 {ECO:0000313|EMBL:AAK44386.1, ECO:0000313|Proteomes:UP000001020};
RN   [1] {ECO:0000313|EMBL:AAK44386.1, ECO:0000313|Proteomes:UP000001020}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh {ECO:0000313|Proteomes:UP000001020};
RX   PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J., DeBoy R., Dodson R., Gwinn M., Haft D., Hickey E.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M., Salzberg S.L.,
RA   Delcher A., Utterback T., Weidman J., Khouri H., Gill J., Mikula A.,
RA   Bishai W., Jacobs Jr W.R.Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2] {ECO:0007829|PDB:1YWF}
RP   X-RAY CRYSTALLOGRAPHY (1.71 ANGSTROMS).
RX   PubMed=16271885; DOI=10.1016/j.str.2005.07.017;
RA   Grundner C., Ng H.L., Alber T.;
RT   "Mycobacterium tuberculosis protein tyrosine phosphatase PtpB structure
RT   reveals a diverged fold and a buried active site.";
RL   Structure 13:1625-1634(2005).
RN   [3] {ECO:0007829|PDB:2OZ5}
RP   X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
RX   PubMed=17437721; DOI=10.1016/j.str.2007.03.003;
RA   Grundner C., Perrin D., Hooft van Huijsduijnen R., Swinnen D., Gonzalez J.,
RA   Gee C.L., Wells T.N., Alber T.;
RT   "Structural basis for selective inhibition of Mycobacterium tuberculosis
RT   protein tyrosine phosphatase PtpB.";
RL   Structure 15:499-509(2007).
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       {ECO:0000256|ARBA:ARBA00009580}.
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DR   EMBL; AE000516; AAK44386.1; -; Genomic_DNA.
DR   PIR; D70618; D70618.
DR   RefSeq; WP_003401010.1; NC_002755.2.
DR   PDB; 1YWF; X-ray; 1.71 A; A=1-276.
DR   PDB; 2OZ5; X-ray; 2.00 A; A/B=1-276.
DR   AlphaFoldDB; P96830; -.
DR   SMR; P96830; -.
DR   BindingDB; P96830; -.
DR   ChEMBL; CHEMBL4540; -.
DR   KEGG; mtc:MT0162; -.
DR   PATRIC; fig|83331.31.peg.176; -.
DR   HOGENOM; CLU_057546_3_1_11; -.
DR   BRENDA; 3.1.3.48; 3445.
DR   EvolutionaryTrace; P96830; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IDA:MTBBASE.
DR   GO; GO:0016791; F:phosphatase activity; IDA:MTBBASE.
DR   GO; GO:0034594; F:phosphatidylinositol trisphosphate phosphatase activity; IDA:MTBBASE.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; IDA:MTBBASE.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IDA:MTBBASE.
DR   GO; GO:0051701; P:biological process involved in interaction with host; IDA:MTBBASE.
DR   CDD; cd14529; TpbA-like; 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR026893; Tyr/Ser_Pase_IphP-type.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   PANTHER; PTHR31126:SF1; TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR31126; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR   Pfam; PF13350; Y_phosphatase3; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PDBsum; 1YWF; -.
DR   PDBsum; 2OZ5; -.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:1YWF, ECO:0007829|PDB:2OZ5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001020}.
FT   DOMAIN          140..214
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
SQ   SEQUENCE   276 AA;  30154 MW;  2794F56866D2E432 CRC64;
     MAVRELPGAW NFRDVADTAT ALRPGRLFRS SELSRLDDAG RATLRRLGIT DVADLRSSRE
     VARRGPGRVP DGIDVHLLPF PDLADDDADD SAPHETAFKR LLTNDGSNGE SGESSQSIND
     AATRYMTDEY RQFPTRNGAQ RALHRVVTLL AAGRPVLTHC FAGKDRTGFV VALVLEAVGL
     DRDVIVADYL RSNDSVPQLR ARISEMIQQR FDTELAPEVV TFTKARLSDG VLGVRAEYLA
     AARQTIDETY GSLGGYLRDA GISQATVNRM RGVLLG
//