ID   P96816_MYCTU            Unreviewed;       340 AA.
AC   P96816; F2GLT6; I6Y2W0; Q7DAE7;
DT   01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1997, sequence version 1.
DT   04-NOV-2026, entry version 160.
DE   SubName: Full=Possible oxidoreductase {ECO:0000313|EMBL:CCP42864.1};
GN   OrderedLocusNames=Rv0139 {ECO:0000313|EMBL:CCP42864.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
OC   Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332 {ECO:0000313|EMBL:CCP42864.1, ECO:0000313|Proteomes:UP000001584};
RN   [1] {ECO:0000313|EMBL:CCP42864.1, ECO:0000313|Proteomes:UP000001584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv {ECO:0000313|Proteomes:UP000001584};
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
RA   Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2] {ECO:0007829|PubMed:21969609}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21969609; DOI=10.1074/mcp.M111.011445;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
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DR   EMBL; AL123456; CCP42864.1; -; Genomic_DNA.
DR   RefSeq; NP_214653.1; NC_000962.3.
DR   RefSeq; WP_003400947.1; NC_000962.3.
DR   AlphaFoldDB; P96816; -.
DR   SMR; P96816; -.
DR   FunCoup; P96816; 23.
DR   STRING; 83332.Rv0139; -.
DR   PaxDb; 83332-Rv0139; -.
DR   DNASU; 886860; -.
DR   GeneID; 886860; -.
DR   KEGG; mtu:Rv0139; -.
DR   KEGG; mtv:RVBD_0139; -.
DR   PATRIC; fig|83332.111.peg.160; -.
DR   TubercuList; Rv0139; -.
DR   eggNOG; COG0451; Bacteria.
DR   InParanoid; P96816; -.
DR   OMA; AACYKLW; -.
DR   OrthoDB; 9801785at2; -.
DR   PhylomeDB; P96816; -.
DR   Proteomes; UP000001584; Chromosome.
DR   AbasyAtlas; P96816; -.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR051783; NAD(P)-dependent_oxidoreduct.
DR   PANTHER; PTHR48079:SF6; NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR48079; PROTEIN YEEZ; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   1: Evidence at protein level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001584}.
FT   DOMAIN          6..234
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   340 AA;  36976 MW;  B825A9645B42F19B CRC64;
     MNAPKLVIGA NGFLGSHVTR QLVADCAPQK GEVRAMVRPA ANTRSIDDLP LTRFHGDVFD
     TATVAEAMAG CDDVYYCVVD TRAWLRDPSP LFRTNVAGLR NVLDVATDAS LRRFVFTSSY
     ATVGRRRGHV ATEEDRVDTR KVTPYVRSRV AAEDLVLQYA HDAGLPAVAM CVSTTYGGGD
     WGRTPHGAFI AGAVFGRLPF TMRGIRLEAV GVDDAARALI LAAERGRNGE RYLISERMMP
     LQEVVRIAAD EAGVPPPRWS ISVPVLYALG ALGSLRARLT GKDTELSLAS VRMMRSEADV
     DHGKAVRELG WQPRPVEESI REAARFWAAM RTVGKDPAAS
//