ID   P90831_CAEEL            Unreviewed;       593 AA.
AC   P90831;
DT   01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 3.
DT   04-NOV-2026, entry version 185.
DE   SubName: Full=Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein {ECO:0000313|EMBL:CAB04081.2};
GN   Name=dars-2 {ECO:0000313|EMBL:CAB04081.2,
GN   ECO:0000313|WormBase:F10C2.6};
GN   ORFNames=CELE_F10C2.6 {ECO:0000313|EMBL:CAB04081.2}, F10C2.6
GN   {ECO:0000313|WormBase:F10C2.6};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB04081.2, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CAB04081.2, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB04081.2,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC       Type 1 subfamily. {ECO:0000256|ARBA:ARBA00006303}.
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DR   EMBL; BX284605; CAB04081.2; -; Genomic_DNA.
DR   PIR; T20702; T20702.
DR   RefSeq; NP_506019.2; NM_073618.8.
DR   AlphaFoldDB; P90831; -.
DR   SMR; P90831; -.
DR   FunCoup; P90831; 2886.
DR   IntAct; P90831; 1.
DR   STRING; 6239.F10C2.6.1; -.
DR   PaxDb; 6239-F10C2.6.1; -.
DR   PeptideAtlas; P90831; -.
DR   GeneID; 3565124; -.
DR   KEGG; cel:CELE_F10C2.6; -.
DR   UCSC; F10C2.6; c. elegans.
DR   AGR; WB:WBGene00001095; -.
DR   CTD; 3565124; -.
DR   WormBase; F10C2.6; CE31906; WBGene00001095; dars-2.
DR   eggNOG; KOG2411; Eukaryota.
DR   HOGENOM; CLU_014330_3_1_1; -.
DR   InParanoid; P90831; -.
DR   OMA; AAADLMC; -.
DR   OrthoDB; 439710at2759; -.
DR   PhylomeDB; P90831; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00001095; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0004815; F:aspartate-tRNA ligase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006422; P:aspartyl-tRNA aminoacylation; IBA:GO_Central.
DR   CDD; cd00777; AspRS_core; 1.
DR   CDD; cd04317; EcAspRS_like_N; 1.
DR   Gene3D; 3.30.930.10; Bira Bifunctional Protein, Domain 2; 1.
DR   Gene3D; 3.30.1360.30; GAD-like domain; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   HAMAP; MF_00044; Asp_tRNA_synth_type1; 1.
DR   InterPro; IPR004364; Aa-tRNA-synt_II.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004524; Asp-tRNA-ligase_1.
DR   InterPro; IPR047089; Asp-tRNA-ligase_1_N.
DR   InterPro; IPR002312; Asp/Asn-tRNA-synth_IIb.
DR   InterPro; IPR047090; AspRS_core.
DR   InterPro; IPR004115; GAD-like_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   NCBIfam; NF001750; aspS; 1.
DR   NCBIfam; TIGR00459; aspS_bact; 1.
DR   PANTHER; PTHR22594:SF5; ASPARTATE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR22594; ASPARTYL/LYSYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF00152; tRNA-synt_2; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   PRINTS; PR01042; TRNASYNTHASP.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE   1: Evidence at protein level;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:P90831};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT   DOMAIN          156..551
FT                   /note="Aminoacyl-transfer RNA synthetases class-II family
FT                   profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50862"
SQ   SEQUENCE   593 AA;  67277 MW;  0F1F329E3AB492E4 CRC64;
     MISARNVTAI CCRRILSTSS YTVRTHICDE LSTSNKNEKV SVMGWLSHKR MDRFFVLRDA
     YGSVQAKISA SSKLQSLLKD IPYESVVRVD GIVVDRGDNR NSKMKTGDIE IDVEELTVLN
     KATSNIPMLP DANANERTRL KYRYIDLRSD KLQKSLRLRS EFVHNVRRFL VEKSGFVDVE
     TPTLFRRTPG GAAEFVVPAP SPNQGLAYSL PQSPQQFKQL LMVGAIDRYF QIARCYRDEG
     SKGDRQPEFT QVDVEMSFTT QNGVMQLIED MIISAWPESL NHIKPKSPFP RIPYSDAMRL
     YGIDKPDMRI PWQIDDVDND IFEFLQKDID DDTWRSRILV CRGAGKTTIS NSMKNEWKRL
     IQMNENGKNF AICHPSQKRW FKPFDNQKLI DQFGLIDEDV LIVCWGNSEG VYWTLEVCGL
     RSKSNVTAHW IVDFPLFSFE EGQLVSTHHP FTAPLEKDID ILYSNDIDKL LQITGQHYDL
     VINGVEMGGG SIRIENSEIQ RHVLKVLGEP TDEMEHLLNA LSHGAPPHGG FALGLDRFVA
     MLTSDGNPLT PVRDVIAFPK TKNGKDLMSD APATLSQKQL ERYGISLLPN AVE
//