ID   PA22_ACAAN     STANDARD;      PRT;   118 AA.
AC   P81237;
DT   15-JUL-1998 (REL. 36, CREATED)
DT   15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE)
DT   15-DEC-1998 (REL. 37, LAST ANNOTATION UPDATE)
DE   PHOSPHOLIPASE A2 (EC 3.1.1.4) (ACANTHIN II) (PHOSPHATIDYLCHOLINE
DE   2-ACYLHYDROLASE).
OS   ACANTHOPHIS ANTARCTICUS (COMMON DEATH ADDER).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; LEPIDOSAURIA; SQUAMATA;
OC   SCLEROGLOSSA; SERPENTES; COLUBROIDEA; ELAPIDAE; ACANTHOPHIINAE;
OC   ACANTHOPHIS.
RN   [1]
RP   SEQUENCE.
RC   TISSUE=VENOM;
RX   MEDLINE; 98303724.
RA   CHOW G., SUBBURAJU S., KINI R.M.;
RT   "Purification, characterization, and amino acid sequence
RT   determination of acanthins, potent inhibitors of platelet aggregation
RT   from Acanthophis antarcticus (common death adder) venom.";
RL   ARCH. BIOCHEM. BIOPHYS. 354:232-238(1998).
CC   -!- FUNCTION: EXHIBITS ANTIPLATELET ACTIVITY.
CC   -!- FUNCTION: PA2 CATALYZES THE CALCIUM-DEPENDENT HYDROLYSIS OF THE
CC       2-ACYL GROUPS IN 3-SN-PHOSPHOGLYCERIDES.
CC   -!- CATALYTIC ACTIVITY: PHOSPHATIDYLCHOLINE + H(2)O = 1-ACYLGLYCERYL-
CC       PHOSPHOCHOLINE + A FATTY ACID ANION.
CC   -!- SIMILARITY: BELONGS TO THE PHOSPHOLIPASE A2 FAMILY.
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DR   PROSITE; PS00118; PA2_HIS; 1.
DR   PROSITE; PS00119; PA2_ASP; FALSE_NEG.
DR   HSSP; P00609; 2NOT.
KW   HYDROLASE; LIPID DEGRADATION; CALCIUM; VENOM.
FT   ACT_SITE     48     48       BY SIMILARITY.
FT   ACT_SITE     92     92       BY SIMILARITY.
FT   DISULFID     11     71       BY SIMILARITY.
FT   DISULFID     27    117       BY SIMILARITY.
FT   DISULFID     29     45       BY SIMILARITY.
FT   DISULFID     44     98       BY SIMILARITY.
FT   DISULFID     51     91       BY SIMILARITY.
FT   DISULFID     60     84       BY SIMILARITY.
FT   DISULFID     78     89       BY SIMILARITY.
FT   CA_BIND      49     49       BY SIMILARITY.
SQ   SEQUENCE   118 AA;  12883 MW;  4B7EBE47 CRC32;
     NLYQFGGMIQ CANKGARSWL SYVNYGCYCG WGGSGTPVDE LDRCCQIHDN CYGEAEKKRC
     GPKMTLYSWE CANDVPVCNS KSACEGFVCD CDAAAAKCFA KAPYNKNNIG IGSKTRCQ
//