ID SRPX_HUMAN Reviewed; 464 AA. AC P78539; A8K065; B3KWP8; B4DDB8; B4DQH5; F5H4D7; G3V1L0; Q4VX66; Q99652; AC Q99913; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1997, sequence version 1. DT 02-SEP-2026, entry version 199. DE RecName: Full=Sushi repeat-containing protein SRPX; DE Flags: Precursor; GN Name=SRPX; Synonyms=ETX1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=8634708; DOI=10.1093/hmg/4.12.2339; RA Meindl A., Carvalho M.R.S., Herrmann K., Lorenz B., Achatz H., Lorenz B., RA Apfelstedt-Sylla E., Wittwer B., Ross M., Meitinger T.; RT "A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in RT patients with X-linked retinitis pigmentosa."; RL Hum. Mol. Genet. 4:2339-2346(1995). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, AND VARIANTS RP LEU-23 DEL; SER-225 AND PHE-413. RX PubMed=8634709; DOI=10.1093/hmg/4.12.2347; RA Dry K.L., Aldred M.A., Edgar A.J., Brown J., Manson F.D., Ho M.-F., RA Prosser J., Hardwick L.J., Lennon A.A., Thomson K., van Keuren M., RA Kurnit D.M., Bird A.C., Jay M., Monaco A.P., Wright A.F.; RT "Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X- RT linked retinitis pigmentosa (RP3)."; RL Hum. Mol. Genet. 4:2347-2353(1995). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT LEU-23 DEL. RX PubMed=9162095; DOI=10.1007/s002510050247; RA Nangaku M., Shankland S.J., Kurokawa K., Bomsztyk K., Johnson R.J., RA Couser W.G.; RT "Cloning of a new human gene with short consensus repeats using the EST RT database."; RL Immunogenetics 46:99-103(1997). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5), AND RP VARIANT LEU-23 DEL. RC TISSUE=Prostate; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., RA Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [9] RP GLYCOSYLATION AT SER-34. RX PubMed=32337544; DOI=10.1093/glycob/cwaa039; RA Toledo A.G., Pihl J., Spliid C.B., Persson A., Nilsson J., Pereira M.A., RA Gustavsson T., Choudhary S., Oo H.Z., Black P.C., Daugaard M., Esko J.D., RA Larson G., Salanti A., Clausen T.M.; RT "An affinity chromatography and glycoproteomics workflow to profile the RT chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in RT the placenta and in cancer."; RL Glycobiology 30:989-1002(2020). RN [10] RP TISSUE SPECIFICITY, AND GLYCOSYLATION AT SER-34. RX PubMed=36213313; DOI=10.1007/s42485-022-00092-3; RA Ramarajan M.G., Saraswat M., Budhraja R., Garapati K., Raymond K., RA Pandey A.; RT "Mass spectrometric analysis of chondroitin sulfate-linked peptides."; RL J. Proteins Proteom. 13:187-203(2022). CC -!- FUNCTION: May be involved in phagocytosis during disk shedding, cell CC adhesion to cells other than the pigment epithelium or signal CC transduction. CC -!- INTERACTION: CC P78539; Q9BRX2: PELO; NbExp=6; IntAct=EBI-2371213, EBI-1043580; CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000305}. Note=Possibly surface CC of photoreceptor cell. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=5; CC Comment=Additional isoforms seem to exist.; CC Name=1; CC IsoId=P78539-1; Sequence=Displayed; CC Name=2; CC IsoId=P78539-2; Sequence=VSP_004430; CC Name=3; CC IsoId=P78539-3; Sequence=VSP_043056; CC Name=4; CC IsoId=P78539-4; Sequence=VSP_045468; CC Name=5; CC IsoId=P78539-5; Sequence=VSP_046757; CC -!- TISSUE SPECIFICITY: Detected in fibroblasts (at protein level) CC (PubMed:36213313). Retina and heart; less in placenta, pancreas, lung, CC liver, skeletal muscle, kidney and brain. CC {ECO:0000269|PubMed:36213313}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U78093; AAB36685.1; -; mRNA. DR EMBL; S82496; AAB37378.1; -; Genomic_DNA. DR EMBL; S82496; AAB37379.1; -; Genomic_DNA. DR EMBL; AK125542; BAG54210.1; -; mRNA. DR EMBL; U61374; AAB40715.1; -; mRNA. DR EMBL; AK289430; BAF82119.1; -; mRNA. DR EMBL; AK293127; BAG56679.1; -; mRNA. DR EMBL; AK298802; BAG60937.1; -; mRNA. DR EMBL; AL121578; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL133494; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL606748; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL627246; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471141; EAW59447.1; -; Genomic_DNA. DR EMBL; BC020684; AAH20684.1; -; mRNA. DR CCDS; CCDS14245.1; -. [P78539-1] DR CCDS; CCDS55400.1; -. [P78539-5] DR CCDS; CCDS55401.1; -. [P78539-3] DR CCDS; CCDS55402.1; -. [P78539-4] DR RefSeq; NP_001164221.1; NM_001170750.2. [P78539-5] DR RefSeq; NP_001164222.1; NM_001170751.2. [P78539-3] DR RefSeq; NP_001164223.1; NM_001170752.2. [P78539-4] DR RefSeq; NP_006298.1; NM_006307.5. [P78539-1] DR AlphaFoldDB; P78539; -. DR BioGRID; 113994; 8. DR FunCoup; P78539; 97. DR IntAct; P78539; 20. DR MINT; P78539; -. DR STRING; 9606.ENSP00000367794; -. DR GlyGen; P78539; 4 sites, 1 O-linked glycan (3 sites). DR iPTMnet; P78539; -. DR PhosphoSitePlus; P78539; -. DR BioMuta; SRPX; -. DR DMDM; 2498958; -. DR jPOST; P78539; -. DR MassIVE; P78539; -. DR PaxDb; 9606-ENSP00000367794; -. DR PeptideAtlas; P78539; -. DR ProteomicsDB; 26540; -. DR ProteomicsDB; 32366; -. DR ProteomicsDB; 57641; -. [P78539-1] DR ProteomicsDB; 57642; -. [P78539-2] DR ProteomicsDB; 57643; -. [P78539-3] DR Antibodypedia; 640; 231 antibodies from 28 providers. DR DNASU; 8406; -. DR Ensembl; ENST00000378533.4; ENSP00000367794.3; ENSG00000101955.16. [P78539-1] DR Ensembl; ENST00000432886.6; ENSP00000411165.2; ENSG00000101955.16. [P78539-3] DR Ensembl; ENST00000538295.5; ENSP00000445034.1; ENSG00000101955.16. [P78539-4] DR Ensembl; ENST00000544439.5; ENSP00000440758.1; ENSG00000101955.16. [P78539-5] DR GeneID; 8406; -. DR KEGG; hsa:8406; -. DR MANE-Select; ENST00000378533.4; ENSP00000367794.3; NM_006307.5; NP_006298.1. DR UCSC; uc004ddy.3; human. [P78539-1] DR AGR; HGNC:11309; -. DR ClinPGx; PA36133; -. DR CTD; 8406; -. DR DisGeNET; 8406; -. DR GeneCards; SRPX; -. DR HGNC; HGNC:11309; SRPX. DR HPA; ENSG00000101955; Tissue enhanced (adipose). DR MIM; 300187; gene. DR OpenTargets; ENSG00000101955; -. DR VEuPathDB; HostDB:ENSG00000101955; -. DR eggNOG; ENOG502QVU2; Eukaryota. DR GeneTree; ENSGT00940000160302; -. DR HOGENOM; CLU_047011_0_0_1; -. DR InParanoid; P78539; -. DR OMA; RIQYTVY; -. DR OrthoDB; 6136178at2759; -. DR PAN-GO; P78539; 1 GO annotation based on evolutionary models. DR PhylomeDB; P78539; -. DR PathwayCommons; P78539; -. DR SignaLink; P78539; -. DR SIGNOR; P78539; -. DR Agora; ENSG00000101955; -. DR BioGRID-ORCS; 8406; 13 hits in 774 CRISPR screens. DR ChiTaRS; SRPX; human. DR GeneWiki; SRPX; -. DR GenomeRNAi; 8406; -. DR Pharos; P78539; Tbio. DR PRO; PR:P78539; -. DR Proteomes; UP000005640; Chromosome X. DR RNAct; P78539; protein. DR Bgee; ENSG00000101955; Expressed in pericardium and 200 other cell types or tissues. DR GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell. DR GO; GO:0031012; C:extracellular matrix; HDA:BHF-UCL. DR GO; GO:0016020; C:membrane; TAS:ProtInc. DR GO; GO:0001845; P:phagolysosome assembly; IBA:GO_Central. DR CDD; cd00033; CCP; 3. DR FunFam; 2.10.70.10:FF:000024; Sushi repeat-containing protein SRPX; 1. DR FunFam; 2.10.70.10:FF:000032; sushi repeat-containing protein SRPX isoform X1; 1. DR Gene3D; 2.10.70.10; Complement Module, domain 1; 3. DR InterPro; IPR025232; DUF4174. DR InterPro; IPR003410; HYR_dom. DR InterPro; IPR043555; SRPX-like. DR InterPro; IPR035976; Sushi/SCR/CCP_sf. DR InterPro; IPR000436; Sushi_SCR_CCP_dom. DR PANTHER; PTHR46343; HYR DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR46343:SF1; SUSHI REPEAT-CONTAINING PROTEIN SRPX; 1. DR Pfam; PF13778; DUF4174; 1. DR Pfam; PF02494; HYR; 1. DR Pfam; PF00084; Sushi; 3. DR SMART; SM00032; CCP; 3. DR SUPFAM; SSF57535; Complement control module/SCR domain; 3. DR PROSITE; PS50825; HYR; 1. DR PROSITE; PS50923; SUSHI; 3. PE 1: Evidence at protein level; KW Alternative splicing; Cell adhesion; Disulfide bond; Glycoprotein; KW Proteoglycan; Proteomics identification; Reference proteome; Repeat; KW Signal; Sushi. FT SIGNAL 1..30 FT /evidence="ECO:0000255" FT CHAIN 31..464 FT /note="Sushi repeat-containing protein SRPX" FT /id="PRO_0000022416" FT DOMAIN 57..117 FT /note="Sushi 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302" FT DOMAIN 118..176 FT /note="Sushi 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302" FT DOMAIN 177..259 FT /note="HYR" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00113" FT DOMAIN 260..319 FT /note="Sushi 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302" FT CARBOHYD 34 FT /note="O-linked (Xyl...) (chondroitin sulfate) serine" FT /evidence="ECO:0000269|PubMed:32337544, FT ECO:0000269|PubMed:36213313" FT DISULFID 57..85 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302" FT DISULFID 69..103 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302" FT DISULFID 89..115 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302" FT DISULFID 120..161 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302" FT DISULFID 147..174 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302" FT DISULFID 262..304 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302" FT DISULFID 290..317 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302" FT VAR_SEQ 1..52 FT /note="MGSPAHRPALLLLLPPLLLLLLLRVPPSRSFPGSGDSPLEDDEVGYSHPRYK FT -> MDFDVGRTTHLSSSPCSASNGGESGQVSKRRCLIGESGH (in isoform 2)" FT /evidence="ECO:0000305" FT /id="VSP_004430" FT VAR_SEQ 33..52 FT /note="Missing (in isoform 5)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_046757" FT VAR_SEQ 117..176 FT /note="QKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWS FT GRPASCVD -> H (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_043056" FT VAR_SEQ 364..464 FT /note="QAQCGLDLRHITVVELVGVFPTLIGRIGAKIMPPALALQLRLLLRIPLYSFS FT MVLVDKHGMDKERYVSLVMPVALFNLIDTFPLRKEEMVLQAEMSQTCNT -> AVAANP FT TLLLQYGASG (in isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_045468" FT VARIANT 23 FT /note="Missing" FT /evidence="ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:8634709, ECO:0000269|PubMed:9162095" FT /id="VAR_005624" FT VARIANT 225 FT /note="P -> S (in dbSNP:rs1123773)" FT /evidence="ECO:0000269|PubMed:8634709" FT /id="VAR_005625" FT VARIANT 413 FT /note="S -> F (in dbSNP:rs35318931)" FT /evidence="ECO:0000269|PubMed:8634709" FT /id="VAR_005626" FT CONFLICT 170..178 FT /note="RPASCVDME -> ASLLCGYG (in Ref. 3; AAB40715)" FT /evidence="ECO:0000305" FT CONFLICT 202 FT /note="Missing (in Ref. 3; AAB40715)" FT /evidence="ECO:0000305" FT CONFLICT 242 FT /note="Y -> H (in Ref. 4; BAG54210)" FT /evidence="ECO:0000305" FT CONFLICT 292 FT /note="G -> S (in Ref. 4; BAF82119)" FT /evidence="ECO:0000305" SQ SEQUENCE 464 AA; 51572 MW; 9CD5E57BC2848680 CRC64; MGSPAHRPAL LLLLPPLLLL LLLRVPPSRS FPGSGDSPLE DDEVGYSHPR YKDTPWCSPI KVKYGDVYCR APQGGYYKTA LGTRCDIRCQ KGYELHGSSL LICQSNKRWS DKVICKQKRC PTLAMPANGG FKCVDGAYFN SRCEYYCSPG YTLKGERTVT CMDNKAWSGR PASCVDMEPP RIKCPSVKER IAEPNKLTVR VSWETPEGRD TADGILTDVI LKGLPPGSNF PEGDHKIQYT VYDRAENKGT CKFRVKVRVK RCGKLNAPEN GYMKCSSDGD NYGATCEFSC IGGYELQGSP ARVCQSNLAW SGTEPTCAAM NVNVGVRTAA ALLDQFYEKR RLLIVSTPTA RNLLYRLQLG MLQQAQCGLD LRHITVVELV GVFPTLIGRI GAKIMPPALA LQLRLLLRIP LYSFSMVLVD KHGMDKERYV SLVMPVALFN LIDTFPLRKE EMVLQAEMSQ TCNT //