ID   LYSQ_ECOLI              Reviewed;         177 AA.
AC   P76159; Q2MB87;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   04-NOV-2026, entry version 154.
DE   RecName: Full=Probable prophage lysozyme {ECO:0000305};
DE            EC=3.2.1.17;
DE   AltName: Full=Endolysin;
DE   AltName: Full=Lysis protein;
DE   AltName: Full=Muramidase;
DE   AltName: Full=Probable lysozyme from lambdoid prophage Qin;
GN   Name=rrrQ; Synonyms=arrQ, ydfQ; OrderedLocusNames=b1554, JW1546;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Enterobacterales; Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Essential for lysis of bacterial cell wall, by showing cell
CC       wall hydrolyzing activity. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC         acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC         between N-acetyl-D-glucosamine residues in chitodextrins.;
CC         EC=3.2.1.17;
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 24 family. {ECO:0000305}.
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DR   EMBL; U00096; AAC74627.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76469.1; -; Genomic_DNA.
DR   PIR; E64910; E64910.
DR   RefSeq; NP_416072.1; NC_000913.3.
DR   RefSeq; WP_001092971.1; NZ_CP009789.1.
DR   AlphaFoldDB; P76159; -.
DR   SMR; P76159; -.
DR   BioGRID; 4259501; 7.
DR   FunCoup; P76159; 18.
DR   IntAct; P76159; 2.
DR   STRING; 511145.b1554; -.
DR   PaxDb; 511145-b1554; -.
DR   EnsemblBacteria; AAC74627; AAC74627; b1554.
DR   GeneID; 946100; -.
DR   KEGG; ecj:JW1546; -.
DR   KEGG; eco:b1554; -.
DR   KEGG; ecoc:C3026_08970; -.
DR   PATRIC; fig|1411691.4.peg.710; -.
DR   EchoBASE; EB3590; -.
DR   eggNOG; COG3772; Bacteria.
DR   HOGENOM; CLU_091641_8_0_6; -.
DR   InParanoid; P76159; -.
DR   OMA; ACWGIEQ; -.
DR   OrthoDB; 8141296at2; -.
DR   PhylomeDB; P76159; -.
DR   BioCyc; EcoCyc:G6827-MONOMER; -.
DR   PRO; PR:P76159; -.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003796; F:lysozyme activity; IBA:GO_Central.
DR   GO; GO:0016998; P:cell wall macromolecule catabolic process; IEA:InterPro.
DR   GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR   CDD; cd16900; endolysin_R21-like; 1.
DR   Gene3D; 1.10.530.40; -; 1.
DR   HAMAP; MF_04110; ENDOLYSIN_T4; 1.
DR   HAMAP; MF_04136; SAR_ENDOLYSIN; 1.
DR   InterPro; IPR051018; Bacteriophage_GH24.
DR   InterPro; IPR034690; Endolysin_T4_type.
DR   InterPro; IPR002196; Glyco_hydro_24.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR023347; Lysozyme_dom_sf.
DR   InterPro; IPR043688; SAR_endolysin-like.
DR   PANTHER; PTHR38107; -; 1.
DR   PANTHER; PTHR38107:SF3; LYSOZYME RRRD-RELATED; 1.
DR   Pfam; PF00959; Phage_lysozyme; 1.
DR   SUPFAM; SSF53955; Lysozyme-like; 1.
PE   3: Inferred from homology;
KW   Antimicrobial; Bacteriolytic enzyme; Glycosidase; Hydrolase;
KW   Reference proteome.
FT   CHAIN           1..177
FT                   /note="Probable prophage lysozyme"
FT                   /id="PRO_0000218110"
FT   ACT_SITE        35
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        44
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   177 AA;  19663 MW;  52DCCA3D315AC888 CRC64;
     MNTKIRYGLS AAVLALIGAG ASAPQILDQF LDEKEGNHTM AYRDGSGIWT ICRGATVVDG
     KTVFPNMKLS KEKCDQVNAI ERDKALAWVE RNIKVPLTEP QKAGIASFCP YNIGPGKCFP
     STFYKRLNAG DRKGACEAIR WWIKDGGRDC RIRSNNCYGQ VIRRDQESAL TCWGIEQ
//