ID   P73377_SYNY3            Unreviewed;       129 AA.
AC   P73377;
DT   01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT   01-FEB-1997, sequence version 1.
DT   02-SEP-2026, entry version 122.
DE   SubName: Full=Mannose-6-phosphate isomerase {ECO:0000313|EMBL:BAA17408.1};
GN   Name=manA {ECO:0000313|EMBL:BAA17408.1};
OS   Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa).
OC   Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC   Merismopediaceae; Synechocystis.
OX   NCBI_TaxID=1111708 {ECO:0000313|EMBL:BAA17408.1, ECO:0000313|Proteomes:UP000001425};
RN   [1] {ECO:0000313|EMBL:BAA17408.1, ECO:0000313|Proteomes:UP000001425}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27184 / PCC 6803 / Kazusa
RC   {ECO:0000313|Proteomes:UP000001425};
RX   PubMed=8590279; DOI=10.1093/dnares/2.4.153;
RA   Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N.,
RA   Sugiura M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region
RT   from map positions 64% to 92% of the genome.";
RL   DNA Res. 2:153-166(1995).
RN   [2] {ECO:0000313|EMBL:BAA17408.1, ECO:0000313|Proteomes:UP000001425}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27184 / PCC 6803 / Kazusa
RC   {ECO:0000313|Proteomes:UP000001425};
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
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DR   EMBL; BA000022; BAA17408.1; -; Genomic_DNA.
DR   PIR; S77561; S77561.
DR   AlphaFoldDB; P73377; -.
DR   STRING; 1148.gene:10498271; -.
DR   PaxDb; 1148-gene:10498271; -.
DR   EnsemblBacteria; BAA17408; BAA17408; BAA17408.
DR   KEGG; syn:slr2074; -.
DR   eggNOG; COG0662; Bacteria.
DR   InParanoid; P73377; -.
DR   PhylomeDB; P73377; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR   GO; GO:0005976; P:polysaccharide metabolic process; IEA:InterPro.
DR   CDD; cd02213; cupin_PMI_typeII_C; 1.
DR   FunFam; 2.60.120.10:FF:000032; Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR001538; Man6P_isomerase-2_C.
DR   InterPro; IPR051161; Mannose-6P_isomerase_type2.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR   PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR   Pfam; PF01050; MannoseP_isomer; 1.
DR   SUPFAM; SSF51182; RmlC-like cupins; 1.
PE   4: Predicted;
KW   Isomerase {ECO:0000313|EMBL:BAA17408.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001425}.
FT   DOMAIN          22..122
FT                   /note="Mannose-6-phosphate isomerase type II C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01050"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   129 AA;  14640 MW;  3D1D150E0CFE1CC0 CRC64;
     MHDSPEASSP APTPHPETTR TPPWGMVTML EEGPRYRINR IVVKPGQHMS TQMHYHRSEH
     WVVVSGTAKV ICNGEEKLLN QKESTYVPMN TPHRVENPGV IDLVMIEVQN GEYLGDDDIV
     RFPEELPKS
//