ID CALC_MOUSE Reviewed; 136 AA. AC P70160; Q8K1K5; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 02-SEP-2026, entry version 186. DE RecName: Full=Calcitonin {ECO:0000303|PubMed:11761712}; DE Flags: Precursor; GN Name=Calca {ECO:0000312|MGI:MGI:2151253}; Synonyms=Calc; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Thyroid; RX PubMed=8806650; DOI=10.1006/bbrc.1996.1371; RA Rehli M., Luger K., Beier W., Falk W.; RT "Molecular cloning and expression of mouse procalcitonin."; RL Biochem. Biophys. Res. Commun. 226:420-425(1996). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/Sv; RX PubMed=11761712; DOI=10.3109/10425170109047567; RA Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.; RT "Structure of the mouse calcitonin/calcitonin gene-related peptide alpha RT and beta genes."; RL DNA Seq. 12:131-135(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Mammary gland; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Calcitonin is a peptide hormone that causes a rapid but CC short-lived drop in the level of calcium and phosphate in blood by CC promoting the incorporation of those ions in the bones. Calcitonin CC function is mediated by the calcitonin receptor/CALCR and the CALCR- CC RAMP2 (AMYR2) receptor complex (By similarity). CC {ECO:0000250|UniProtKB:P01258}. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Calcitonin; CC IsoId=P70160-1; Sequence=Displayed; CC Name=Calcitonin-gene related peptide I; CC IsoId=Q99JA0-1; Sequence=External; CC -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X97991; CAA66630.1; -; mRNA. DR EMBL; AF325522; AAK18180.1; -; Genomic_DNA. DR EMBL; AF325521; AAK18180.1; JOINED; Genomic_DNA. DR EMBL; BC030071; AAH30071.1; -; mRNA. DR CCDS; CCDS21763.1; -. [P70160-1] DR PIR; JC4977; JC4977. DR RefSeq; NP_001292545.1; NM_001305616.1. [P70160-1] DR RefSeq; NP_031613.2; NM_007587.2. [P70160-1] DR RefSeq; XP_030097891.1; XM_030242031.1. [P70160-1] DR AlphaFoldDB; P70160; -. DR SMR; P70160; -. DR FunCoup; P70160; 504. DR STRING; 10090.ENSMUSP00000032907; -. DR GlyCosmos; P70160; 1 site, No reported glycans. DR GlyGen; P70160; 1 site. DR PhosphoSitePlus; P70160; -. DR PaxDb; 10090-ENSMUSP00000032907; -. DR ProteomicsDB; 265326; -. [P70160-1] DR Antibodypedia; 3493; 1852 antibodies from 53 providers. DR DNASU; 12310; -. DR Ensembl; ENSMUST00000032907.9; ENSMUSP00000032907.8; ENSMUSG00000030669.14. DR Ensembl; ENSMUST00000206853.2; ENSMUSP00000146328.2; ENSMUSG00000030669.14. DR GeneID; 12310; -. DR KEGG; mmu:12310; -. DR UCSC; uc009jig.2; mouse. [P70160-1] DR AGR; MGI:2151253; -. DR CTD; 796; -. DR MGI; MGI:2151253; Calca. DR VEuPathDB; HostDB:ENSMUSG00000030669; -. DR eggNOG; ENOG502RZI5; Eukaryota. DR GeneTree; ENSGT00940000162876; -. DR HOGENOM; CLU_122444_0_0_1; -. DR InParanoid; P70160; -. DR OrthoDB; 9929923at2759; -. DR PhylomeDB; P70160; -. DR Reactome; R-MMU-418555; G alpha (s) signalling events. DR Reactome; R-MMU-419812; Calcitonin-like ligand receptors. DR BioGRID-ORCS; 12310; 0 hits in 79 CRISPR screens. DR Proteomes; UP000000589; Chromosome 7. DR RNAct; P70160; protein. DR Bgee; ENSMUSG00000030669; Expressed in facial nucleus and 100 other cell types or tissues. DR ExpressionAtlas; P70160; baseline and differential. DR GO; GO:0030424; C:axon; IDA:MGI. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0005576; C:extracellular region; IDA:MGI. DR GO; GO:0098686; C:hippocampal mossy fiber to CA3 synapse; ISO:GO_Central. DR GO; GO:0043005; C:neuron projection; IDA:MGI. DR GO; GO:0043025; C:neuronal cell body; ISO:GO_Central. DR GO; GO:0098992; C:neuronal dense core vesicle; ISO:GO_Central. DR GO; GO:0043195; C:terminal bouton; IDA:MGI. DR GO; GO:0031716; F:calcitonin receptor binding; IDA:MGI. DR GO; GO:0005179; F:hormone activity; ISO:GO_Central. DR GO; GO:0042802; F:identical protein binding; ISO:GO_Central. DR GO; GO:0044877; F:protein-containing complex binding; ISO:GO_Central. DR GO; GO:0005102; F:signaling receptor binding; IDA:MGI. DR GO; GO:0007190; P:activation of adenylate cyclase activity; IDA:MGI. DR GO; GO:0032147; P:activation of protein kinase activity; ISO:GO_Central. DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IGI:MGI. DR GO; GO:0150059; P:amylin receptor 1 signaling pathway; ISO:GO_Central. DR GO; GO:0150060; P:amylin receptor 2 signaling pathway; ISO:GO_Central. DR GO; GO:0001984; P:artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; IMP:MGI. DR GO; GO:0097646; P:calcitonin family receptor signaling pathway; ISO:GO_Central. DR GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; ISO:GO_Central. DR GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IDA:MGI. DR GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IMP:MGI. DR GO; GO:0007566; P:embryo implantation; ISO:GO_Central. DR GO; GO:0043542; P:endothelial cell migration; ISO:GO_Central. DR GO; GO:0001935; P:endothelial cell proliferation; ISO:GO_Central. DR GO; GO:0007631; P:feeding behavior; IDA:MGI. DR GO; GO:0002031; P:G protein-coupled receptor internalization; ISO:GO_Central. DR GO; GO:0006954; P:inflammatory response; IDA:MGI. DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IGI:MGI. DR GO; GO:0007159; P:leukocyte cell-cell adhesion; ISO:GO_Central. DR GO; GO:0002548; P:monocyte chemotaxis; ISO:GO_Central. DR GO; GO:0045776; P:negative regulation of blood pressure; IMP:MGI. DR GO; GO:0045779; P:negative regulation of bone resorption; ISO:GO_Central. DR GO; GO:0010523; P:negative regulation of calcium ion transport into cytosol; ISO:GO_Central. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISO:GO_Central. DR GO; GO:0030279; P:negative regulation of ossification; IMP:MGI. DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISO:GO_Central. DR GO; GO:0045986; P:negative regulation of smooth muscle contraction; IDA:MGI. DR GO; GO:0001976; P:nervous system process involved in regulation of systemic arterial blood pressure; ISA:MGI. DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI. DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; ISO:GO_Central. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:GO_Central. DR GO; GO:0032730; P:positive regulation of interleukin-1 alpha production; ISO:GO_Central. DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:GO_Central. DR GO; GO:0045651; P:positive regulation of macrophage differentiation; ISO:GO_Central. DR GO; GO:0006468; P:protein phosphorylation; ISO:GO_Central. DR GO; GO:0031623; P:receptor internalization; ISO:GO_Central. DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; ISO:GO_Central. DR GO; GO:0009408; P:response to heat; IMP:MGI. DR GO; GO:0048265; P:response to pain; IMP:MGI. DR GO; GO:0048240; P:sperm capacitation; ISA:MGI. DR GO; GO:0001944; P:vasculature development; ISO:GO_Central. DR GO; GO:0042311; P:vasodilation; ISO:GO_Central. DR InterPro; IPR021118; Calcitonin. DR InterPro; IPR021117; Calcitonin-like. DR InterPro; IPR021116; Calcitonin/adrenomedullin. DR InterPro; IPR018360; Calcitonin_CS. DR InterPro; IPR001693; Calcitonin_peptide-like. DR PANTHER; PTHR10505:SF16; CALCITONIN; 1. DR PANTHER; PTHR10505; CALCITONIN-RELATED; 1. DR Pfam; PF00214; Calc_CGRP_IAPP; 1. DR PRINTS; PR00270; CALCITONINA. DR SMART; SM00113; CALCITONIN; 1. DR PROSITE; PS00258; CALCITONIN; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Amidation; Cleavage on pair of basic residues; KW Disulfide bond; Glycoprotein; Hormone; Phosphoprotein; Reference proteome; KW Secreted; Signal. FT SIGNAL 1..25 FT /evidence="ECO:0000255" FT PROPEP 26..82 FT /id="PRO_0000004056" FT PEPTIDE 85..116 FT /note="Calcitonin" FT /id="PRO_0000004057" FT PROPEP 121..136 FT /id="PRO_0000004058" FT REGION 63..84 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 114..136 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 116..130 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 42 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P01257" FT MOD_RES 116 FT /note="Proline amide" FT /evidence="ECO:0000250" FT CARBOHYD 87 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000305" FT DISULFID 85..91 FT /evidence="ECO:0000250|UniProtKB:P01258" FT CONFLICT 108 FT /note="Q -> K (in Ref. 3; AAH30071)" FT /evidence="ECO:0000305" SQ SEQUENCE 136 AA; 15141 MW; B7F1DD27F7E10DE5 CRC64; MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA ALVQDYMQMK ARELEQEEEQ EAEGSSLDSP RSKRCGNLST CMLGTYTQDL NKFHTFPQTS IGVEAPGKKR DVAKDLETNH QSHFGN //