ID   CAPSD_TMV               Reviewed;         159 AA.
AC   P69687; P03570;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   02-SEP-2026, entry version 91.
DE   RecName: Full=Capsid protein;
DE   AltName: Full=Coat protein;
GN   Name=CP;
OS   Tobacco mosaic virus (strain vulgare) (TMV) (Tobacco mosaic virus (strain
OS   U1)).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC   Martellivirales; Virgaviridae; Tobamovirus; Tobamovirus tabaci;
OC   Tobacco mosaic virus.
OX   NCBI_TaxID=12243;
OH   NCBI_TaxID=4097; Nicotiana tabacum (Common tobacco).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=6964389; DOI=10.1073/pnas.79.19.5818;
RA   Goelet P., Lomonossoff G.P., Butler P.J.G., Akam M.E., Gait M.J., Karn J.;
RT   "Nucleotide sequence of tobacco mosaic virus RNA.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:5818-5822(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=109810; DOI=10.1093/nar/6.4.1287;
RA   Guilley H., Jonard G., Kukla B., Richards K.E.;
RT   "Sequence of 1000 nucleotides at the 3' end of tobacco mosaic virus RNA.";
RL   Nucleic Acids Res. 6:1287-1308(1979).
RN   [3]
RP   PRELIMINARY PROTEIN SEQUENCE OF 2-159, AND ACETYLATION AT SER-2.
RX   PubMed=16590772; DOI=10.1073/pnas.46.11.1463;
RA   Tsugita A., Gish D.T., Young J., Fraenkel-Conrat H., Knight C.A.,
RA   Stanley W.M.;
RT   "The complete amino acid sequence of the protein of tobacco mosaic virus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 46:1463-1469(1960).
RN   [4]
RP   PROTEIN SEQUENCE OF 2-42 AND 94-113, AND SEQUENCE REVISION.
RX   PubMed=14165501; DOI=10.1016/0003-9861(64)90232-2;
RA   Funatsu G., Tsugita A., Fraenkel-Conrat H.;
RT   "Studies on the amino acid sequence of tobacco mosaic virus protein. V.
RT   Amino acid sequences of two peptides from tryptic digests and location of
RT   amide group.";
RL   Arch. Biochem. Biophys. 105:25-41(1964).
RN   [5]
RP   PROTEIN SEQUENCE OF 2-159.
RA   Anderer F.A., Handschuh D.;
RT   "The sequence of amino acids in the protein of tobacco mosaic virus. IV.
RT   Separation of tobacco mosaic virus protein with trypsin.";
RL   Z. Naturforsch. B 17:536-543(1962).
RN   [6]
RP   SEQUENCE REVISION.
RX   PubMed=4381389; DOI=10.1515/znb-1965-1212;
RA   Anderer F.A., Wittmann-Liebold B., Wittmann H.G.;
RT   "Further studies on amino acid sequence of proteins in tobacco mosaic
RT   virus.";
RL   Z. Naturforsch. B 20:1203-1213(1965).
RN   [7]
RP   SEQUENCE REVISION.
RX   PubMed=5452764;
RA   Nozu Y., Ohno T., Okada Y.;
RT   "Amino acid sequences of some common Japanese strains of tobacco mosaic
RT   virus.";
RL   J. Biochem. 68:39-52(1970).
RN   [8]
RP   MUTANTS DEFECTIVE CAPSID PM2; DT1 AND DT2.
RX   PubMed=8341610; DOI=10.1093/nar/21.14.3325;
RA   Kuhlmann U., Sarkar S., Rohde W.;
RT   "Capsid protein gene sequences of four tobacco mosaic virus strains
RT   defective for virus assembly.";
RL   Nucleic Acids Res. 21:3325-3325(1993).
RN   [9]
RP   X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS) OF 1-159.
RX   PubMed=3952490; DOI=10.1126/science.3952490;
RA   Namba K., Stubbs G.;
RT   "Structure of tobacco mosaic virus at 3.6-A resolution: implications for
RT   assembly.";
RL   Science 231:1401-1406(1986).
CC   -!- FUNCTION: Capsid protein self-assembles to form rod-shaped virions
CC       about 18 nm in diameter with a central canal enclosing the viral
CC       genomic RNA.
CC   -!- INTERACTION:
CC       P69687; P69687: CP; NbExp=2; IntAct=EBI-15927445, EBI-15927445;
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the virgaviridae capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; V01408; -; NOT_ANNOTATED_CDS; Unassigned_RNA.
DR   EMBL; V01409; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; V01406; CAA24685.1; -; Genomic_RNA.
DR   EMBL; X70882; CAA50227.1; -; mRNA.
DR   EMBL; X70883; CAA50228.1; -; mRNA.
DR   EMBL; X70884; CAA50229.1; -; mRNA.
DR   RefSeq; NP_597750.1; NC_001367.1.
DR   PDB; 1EI7; X-ray; 2.45 A; A/B=2-159.
DR   PDB; 2TMV; Fiber; 2.90 A; P=2-159.
DR   PDB; 3J06; EM; -; A=1-159.
DR   PDB; 3KML; X-ray; 3.01 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q=2-100.
DR   PDB; 4GQH; X-ray; 3.06 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d=2-155.
DR   PDB; 4UDV; EM; 3.35 A; A=2-159.
DR   PDB; 6I5A; EM; 2.30 A; A=1-159.
DR   PDB; 6R7M; EM; 1.92 A; A=2-154.
DR   PDB; 6RLP; EM; 2.30 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/S/T/U/V/W/X/Y=2-154.
DR   PDB; 6SAE; EM; 1.90 A; A=2-159.
DR   PDB; 6SAG; EM; 2.00 A; A=2-159.
DR   PDB; 6X0Q; X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q=2-100.
DR   PDB; 6X0R; X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q=2-100.
DR   PDB; 7Q22; EM; 6.30 A; A=2-154.
DR   PDB; 7Q23; EM; 4.30 A; A=2-154.
DR   PDB; 7Q2Q; EM; 4.30 A; A=2-154.
DR   PDB; 7Q2R; EM; 3.50 A; A=2-154.
DR   PDB; 7Q2S; EM; 3.70 A; A=2-154.
DR   PDB; 8EAW; X-ray; 2.80 A; a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q=2-159.
DR   EMDB; EMD-10129; -.
DR   EMDB; EMD-10130; -.
DR   EMDB; EMD-13778; -.
DR   EMDB; EMD-13779; -.
DR   EMDB; EMD-13780; -.
DR   EMDB; EMD-13781; -.
DR   EMDB; EMD-13782; -.
DR   EMDB; EMD-4413; -.
DR   EMDB; EMD-5185; -.
DR   EMDB; EMD-53716; -.
DR   EMDB; EMD-53717; -.
DR   EMDB; EMD-53718; -.
DR   EMDB; EMD-53720; -.
DR   EMDB; EMD-55006; -.
DR   SMR; P69687; -.
DR   DIP; DIP-59677N; -.
DR   iPTMnet; P69687; -.
DR   ABCD; P69687; 6 sequenced antibodies.
DR   GeneID; 1494080; -.
DR   KEGG; vg:1494080; -.
DR   EvolutionaryTrace; P69687; -.
DR   Proteomes; UP000000522; Segment.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 1.20.120.70; Tobacco mosaic virus-like, coat protein; 1.
DR   InterPro; IPR001337; TMV-like_coat.
DR   InterPro; IPR036417; TMV-like_coat_sf.
DR   Pfam; PF00721; TMV_coat; 1.
DR   SUPFAM; SSF47195; TMV-like viral coat proteins; 1.
DR   PDBsum; 1EI7; -.
DR   PDBsum; 2TMV; -.
DR   PDBsum; 3J06; -.
DR   PDBsum; 3KML; -.
DR   PDBsum; 4GQH; -.
DR   PDBsum; 4UDV; -.
DR   PDBsum; 6I5A; -.
DR   PDBsum; 6R7M; -.
DR   PDBsum; 6RLP; -.
DR   PDBsum; 6SAE; -.
DR   PDBsum; 6SAG; -.
DR   PDBsum; 6X0Q; -.
DR   PDBsum; 6X0R; -.
DR   PDBsum; 7Q22; -.
DR   PDBsum; 7Q23; -.
DR   PDBsum; 7Q2Q; -.
DR   PDBsum; 7Q2R; -.
DR   PDBsum; 7Q2S; -.
DR   PDBsum; 8EAW; -.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Capsid protein; Direct protein sequencing;
KW   Helical capsid protein; Reference proteome; Virion.
FT   INIT_MET        1
FT                   /note="Removed; by host"
FT                   /evidence="ECO:0000269|PubMed:14165501, ECO:0000269|Ref.5"
FT   CHAIN           2..159
FT                   /note="Capsid protein"
FT                   /id="PRO_0000144918"
FT   MOD_RES         2
FT                   /note="N-acetylserine; by host"
FT                   /evidence="ECO:0000269|PubMed:16590772"
FT   VARIANT         29
FT                   /note="T -> I (in PM2; DT1 and DT2)"
FT   VARIANT         79
FT                   /note="P -> S (in DT2)"
FT   VARIANT         96
FT                   /note="E -> D (in PM2; DT1 and DT2)"
FT   VARIANT         104
FT                   /note="T -> M (in PM2)"
FT   VARIANT         138
FT                   /note="G -> R (in DT1 and DT2)"
FT   VARIANT         149
FT                   /note="S -> Y (in DT2)"
FT   STRAND          2..4
FT                   /evidence="ECO:0007829|PDB:6X0Q"
FT   HELIX           8..14
FT                   /evidence="ECO:0007829|PDB:6SAE"
FT   HELIX           21..31
FT                   /evidence="ECO:0007829|PDB:6SAE"
FT   STRAND          32..34
FT                   /evidence="ECO:0007829|PDB:3J06"
FT   STRAND          36..38
FT                   /evidence="ECO:0007829|PDB:3J06"
FT   HELIX           39..51
FT                   /evidence="ECO:0007829|PDB:6SAE"
FT   STRAND          59..61
FT                   /evidence="ECO:0007829|PDB:6R7M"
FT   HELIX           62..64
FT                   /evidence="ECO:0007829|PDB:6SAE"
FT   STRAND          69..71
FT                   /evidence="ECO:0007829|PDB:6SAE"
FT   HELIX           77..87
FT                   /evidence="ECO:0007829|PDB:6SAE"
FT   HELIX           93..97
FT                   /evidence="ECO:0007829|PDB:6SAE"
FT   STRAND          99..101
FT                   /evidence="ECO:0007829|PDB:6R7M"
FT   HELIX           102..104
FT                   /evidence="ECO:0007829|PDB:6SAE"
FT   HELIX           105..134
FT                   /evidence="ECO:0007829|PDB:6SAE"
FT   TURN            135..138
FT                   /evidence="ECO:0007829|PDB:6SAE"
FT   HELIX           142..148
FT                   /evidence="ECO:0007829|PDB:6SAE"
FT   STRAND          152..154
FT                   /evidence="ECO:0007829|PDB:4GQH"
SQ   SEQUENCE   159 AA;  17624 MW;  5C90E8478A43DBC4 CRC64;
     MSYSITTPSQ FVFLSSAWAD PIELINLCTN ALGNQFQTQQ ARTVVQRQFS EVWKPSPQVT
     VRFPDSDFKV YRYNAVLDPL VTALLGAFDT RNRIIEVENQ ANPTTAETLD ATRRVDDATV
     AIRSAINNLI VELIRGTGSY NRSSFESSSG LVWTSGPAT
//