ID OTCC1_STRA5 Reviewed; 332 AA. AC P65604; Q8DWT7; Q8E2N7; DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot. DT 11-OCT-2004, sequence version 1. DT 02-SEP-2026, entry version 117. DE RecName: Full=Ornithine carbamoyltransferase 1, catabolic; DE Short=OTCase 1; DE EC=2.1.3.3; GN Name=arcB1; OrderedLocusNames=SAG2126; OS Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R). OC Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=208435; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC BAA-611 / 2603 V/R; RX PubMed=12200547; DOI=10.1073/pnas.182380799; RA Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N., RA Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D., RA Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C., RA DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Lewis M.R., Radune D., RA Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A., RA Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T., RA Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D., RA Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M.; RT "Complete genome sequence and comparative genomic analysis of an emerging RT human pathogen, serotype V Streptococcus agalactiae."; RL Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002). CC -!- FUNCTION: Reversibly catalyzes the transfer of the carbamoyl group from CC carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to CC produce L-citrulline. {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + CC H(+); Xref=Rhea:RHEA:19513, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:46911, ChEBI:CHEBI:57743, ChEBI:CHEBI:58228; EC=2.1.3.3; CC -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI CC pathway; carbamoyl phosphate from L-arginine: step 2/2. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. CC -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase CC superfamily. OTCase family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE009948; AAN00984.1; -; Genomic_DNA. DR RefSeq; WP_000793622.1; NC_004116.1. DR AlphaFoldDB; P65604; -. DR SMR; P65604; -. DR STRING; 208435.SAG2126; -. DR PaxDb; 208435-SAG2126; -. DR GeneID; 66886861; -. DR KEGG; sag:SAG2126; -. DR PATRIC; fig|208435.3.peg.2129; -. DR HOGENOM; CLU_043846_3_1_9; -. DR OrthoDB; 9802587at2; -. DR UniPathway; UPA00254; UER00365. DR Proteomes; UP000000821; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0016597; F:amino acid binding; IEA:InterPro. DR GO; GO:0004585; F:ornithine carbamoyltransferase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006527; P:L-arginine catabolic process; IEA:UniProtKB-UniRule. DR GO; GO:0019240; P:L-citrulline biosynthetic process; IEA:TreeGrafter. DR Gene3D; 3.40.50.1370; Aspartate/ornithine carbamoyltransferase; 2. DR HAMAP; MF_01109; OTCase; 1. DR InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd. DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase. DR InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf. DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd. DR InterPro; IPR002292; Orn/put_carbamltrans. DR InterPro; IPR024904; OTCase_ArgI. DR NCBIfam; TIGR00658; orni_carb_tr; 1. DR NCBIfam; NF001986; PRK00779.1; 1. DR NCBIfam; NF003286; PRK04284.1; 1. DR PANTHER; PTHR45753:SF2; ORNITHINE CARBAMOYLTRANSFERASE; 1. DR PANTHER; PTHR45753; ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL; 1. DR Pfam; PF00185; OTCace; 1. DR Pfam; PF02729; OTCace_N; 1. DR PRINTS; PR00100; AOTCASE. DR PRINTS; PR00102; OTCASE. DR SUPFAM; SSF53671; Aspartate/ornithine carbamoyltransferase; 1. DR PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1. PE 3: Inferred from homology; KW Arginine metabolism; Cytoplasm; Reference proteome; Transferase. FT CHAIN 1..332 FT /note="Ornithine carbamoyltransferase 1, catabolic" FT /id="PRO_0000113026" FT BINDING 56..59 FT /ligand="carbamoyl phosphate" FT /ligand_id="ChEBI:CHEBI:58228" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01109" FT BINDING 83 FT /ligand="carbamoyl phosphate" FT /ligand_id="ChEBI:CHEBI:58228" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01109" FT BINDING 107 FT /ligand="carbamoyl phosphate" FT /ligand_id="ChEBI:CHEBI:58228" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01109" FT BINDING 134..137 FT /ligand="carbamoyl phosphate" FT /ligand_id="ChEBI:CHEBI:58228" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01109" FT BINDING 167 FT /ligand="L-ornithine" FT /ligand_id="ChEBI:CHEBI:46911" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01109" FT BINDING 231 FT /ligand="L-ornithine" FT /ligand_id="ChEBI:CHEBI:46911" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01109" FT BINDING 235..236 FT /ligand="L-ornithine" FT /ligand_id="ChEBI:CHEBI:46911" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01109" FT BINDING 273..274 FT /ligand="carbamoyl phosphate" FT /ligand_id="ChEBI:CHEBI:58228" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01109" FT BINDING 318 FT /ligand="carbamoyl phosphate" FT /ligand_id="ChEBI:CHEBI:58228" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01109" SQ SEQUENCE 332 AA; 37220 MW; B51A22BF6135652B CRC64; MKNLRNRSFL TLLDFSTAEV EFLLKLSEDL KRAKYAGIEQ QKLVGKNIAL IFEKDSTRTR CAFEVAAHDQ GAHVTYLGPT GSQMGKKETS KDTARVLGGM YDGIEYRGFS QETVETLAEF SGVPVWNGLT DADHPTQVLA DFLTAKECLH KPYKDIRFTY VGDGRNNVAN ALMIGASIVG MTYHLVCPKE LEPDPELLSK CQEIAKTTGA SIEITADIAE GVRDSDVLYT DVWVSMGEPD EVWKERIALL EPYRITQEML NMTENPNVIF EHCLPSFHNI DTKVGYDIYE KYGLKEMEVS DEVFEGPHSV VFQEAENRMH TIKAVMVATL GD //