ID   LACA_STAAW              Reviewed;         142 AA.
AC   P65252; Q99S74;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   02-SEP-2026, entry version 101.
DE   RecName: Full=Galactose-6-phosphate isomerase subunit LacA {ECO:0000255|HAMAP-Rule:MF_01555};
DE            EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01555};
GN   Name=lacA {ECO:0000255|HAMAP-Rule:MF_01555}; OrderedLocusNames=MW2121;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Bacillati; Bacillota; Bacilli; Caryophanales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC         phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC         ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01555};
CC   -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC       D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_01555}.
CC   -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC       {ECO:0000255|HAMAP-Rule:MF_01555}.
CC   -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01555}.
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DR   EMBL; BA000033; BAB95986.1; -; Genomic_DNA.
DR   RefSeq; WP_000974608.1; NC_003923.1.
DR   AlphaFoldDB; P65252; -.
DR   SMR; P65252; -.
DR   GeneID; 98347039; -.
DR   KEGG; sam:MW2121; -.
DR   HOGENOM; CLU_091396_4_2_9; -.
DR   UniPathway; UPA00702; UER00714.
DR   GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004751; F:ribose-5-phosphate isomerase activity; IEA:TreeGrafter.
DR   GO; GO:0019316; P:D-allose catabolic process; IEA:TreeGrafter.
DR   GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR   GO; GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; IEA:TreeGrafter.
DR   Gene3D; 3.40.1400.10; Sugar-phosphate isomerase, RpiB/LacA/LacB; 1.
DR   HAMAP; MF_01555; LacA; 1.
DR   InterPro; IPR004783; LacA.
DR   InterPro; IPR003500; RpiB_LacA_LacB.
DR   InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR   NCBIfam; TIGR01118; lacA; 1.
DR   NCBIfam; NF006380; PRK08621.1; 1.
DR   NCBIfam; TIGR00689; rpiB_lacA_lacB; 1.
DR   PANTHER; PTHR30345:SF5; GALACTOSE-6-PHOSPHATE ISOMERASE SUBUNIT LACA; 1.
DR   PANTHER; PTHR30345; RIBOSE-5-PHOSPHATE ISOMERASE B; 1.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   SUPFAM; SSF89623; Ribose/Galactose isomerase RpiB/AlsB; 1.
PE   3: Inferred from homology;
KW   Isomerase; Lactose metabolism.
FT   CHAIN           1..142
FT                   /note="Galactose-6-phosphate isomerase subunit LacA"
FT                   /id="PRO_0000208110"
SQ   SEQUENCE   142 AA;  15395 MW;  A52C4A7DBF30BE19 CRC64;
     MAIIIGSDEA GKRLKEVIKS YLLDNKYDVV DVTEGQEVDF VDATLAVAKD VQSQEGNLGI
     VIDAFGAGSF MVATKIKGMI AAEVSDERSG YMTRGHNNSR MITMGSEIVG DTLAKNVVKG
     FVEGKYDGGR HQIRVDMLNK MC
//