ID H4_PLADU Reviewed; 103 AA. AC P62795; P02304; P02305; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 2. DT 02-SEP-2026, entry version 101. DE RecName: Full=Histone H4; OS Platynereis dumerilii (Dumeril's clam worm). OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta; OC Errantia; Phyllodocida; Nereididae; Platynereis. OX NCBI_TaxID=6359; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Sperm; RX PubMed=2194796; DOI=10.1111/j.1432-1033.1990.tb15540.x; RA Sellos D., Krawetz S.A., Dixon G.H.; RT "Organization and complete nucleotide sequence of the core-histone-gene RT cluster of the annelid Platynereis dumerilii."; RL Eur. J. Biochem. 190:21-29(1990). CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact CC DNA into chromatin, limiting DNA accessibility to the cellular CC machineries which require DNA as a template. Histones thereby play a CC central role in transcription regulation, DNA repair, DNA replication CC and chromosomal stability. DNA accessibility is regulated via a complex CC set of post-translational modifications of histones, also called CC histone code, and nucleosome remodeling. CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of CC DNA. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. CC -!- SIMILARITY: Belongs to the histone H4 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X53330; CAA37414.1; -; Genomic_DNA. DR AlphaFoldDB; P62795; -. DR SMR; P62795; -. DR MINT; P62795; -. DR EnsemblMetazoa; TCONS_00107459.p2; cds.TCONS_00107459.p2; XLOC_040613. DR EnsemblMetazoa; TCONS_00107461.p2; cds.TCONS_00107461.p2; XLOC_040615. DR EnsemblMetazoa; TCONS_00107462.p2; cds.TCONS_00107462.p2; XLOC_040616. DR EnsemblMetazoa; TCONS_00107464.p1; cds.TCONS_00107464.p1; XLOC_040618. DR EnsemblMetazoa; TCONS_00107466.p2; cds.TCONS_00107466.p2; XLOC_040620. DR EnsemblMetazoa; TCONS_00107468.p2; cds.TCONS_00107468.p2; XLOC_040622. DR EnsemblMetazoa; TCONS_00107470.p2; cds.TCONS_00107470.p2; XLOC_040624. DR EnsemblMetazoa; TCONS_00107471.p2; cds.TCONS_00107471.p2; XLOC_040625. DR EnsemblMetazoa; TCONS_00107474.p2; cds.TCONS_00107474.p2; XLOC_040628. DR EnsemblMetazoa; TCONS_00107475.p2; cds.TCONS_00107475.p2; XLOC_040629. DR EnsemblMetazoa; TCONS_00107476.p2; cds.TCONS_00107476.p2; XLOC_040630. DR EnsemblMetazoa; TCONS_00107478.p2; cds.TCONS_00107478.p2; XLOC_040632. DR EnsemblMetazoa; TCONS_00107479.p2; cds.TCONS_00107479.p2; XLOC_040633. DR EnsemblMetazoa; TCONS_00107483.p2; cds.TCONS_00107483.p2; XLOC_040637. DR EnsemblMetazoa; TCONS_00107485.p2; cds.TCONS_00107485.p2; XLOC_040639. DR EnsemblMetazoa; TCONS_00107486.p2; cds.TCONS_00107486.p2; XLOC_040640. DR EnsemblMetazoa; TCONS_00107490.p2; cds.TCONS_00107490.p2; XLOC_040644. DR EnsemblMetazoa; TCONS_00107491.p1; cds.TCONS_00107491.p1; XLOC_040645. DR EnsemblMetazoa; TCONS_00123949.p2; cds.TCONS_00123949.p2; XLOC_047801. DR EnsemblMetazoa; TCONS_00123950.p2; cds.TCONS_00123950.p2; XLOC_047802. DR EnsemblMetazoa; TCONS_00123951.p2; cds.TCONS_00123951.p2; XLOC_047803. DR EnsemblMetazoa; TCONS_00123952.p2; cds.TCONS_00123952.p2; XLOC_047804. DR EnsemblMetazoa; TCONS_00123954.p2; cds.TCONS_00123954.p2; XLOC_047806. DR EnsemblMetazoa; TCONS_00123955.p2; cds.TCONS_00123955.p2; XLOC_047807. DR EnsemblMetazoa; TCONS_00123956.p2; cds.TCONS_00123956.p2; XLOC_047808. DR EnsemblMetazoa; TCONS_00123957.p1; cds.TCONS_00123957.p1; XLOC_047809. DR EnsemblMetazoa; TCONS_00123958.p1; cds.TCONS_00123958.p1; XLOC_047810. DR EnsemblMetazoa; TCONS_00123959.p2; cds.TCONS_00123959.p2; XLOC_047811. DR EnsemblMetazoa; TCONS_00130759.p2; cds.TCONS_00130759.p2; XLOC_049898. DR EnsemblMetazoa; TCONS_00130760.p7; cds.TCONS_00130760.p7; XLOC_049899. DR GO; GO:0000786; C:nucleosome; IEA:InterPro. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro. DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro. DR CDD; cd22912; HFD_H4; 1. DR FunFam; 1.10.20.10:FF:000002; Histone H4; 1. DR Gene3D; 1.10.20.10; Histone, subunit A; 1. DR InterPro; IPR035425; CENP-T/H4_C. DR InterPro; IPR009072; Histone-fold. DR InterPro; IPR001951; Histone_H4. DR InterPro; IPR019809; Histone_H4_CS. DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom. DR PANTHER; PTHR10484; HISTONE H4; 1. DR Pfam; PF15511; CENP-T_C; 1. DR PRINTS; PR00623; HISTONEH4. DR SMART; SM00417; H4; 1. DR SMART; SM00803; TAF; 1. DR SUPFAM; SSF47113; Histone-fold; 1. DR PROSITE; PS00047; HISTONE_H4; 1. PE 3: Inferred from homology; KW Acetylation; Chromosome; DNA-binding; Methylation; Nucleosome core; KW Nucleus. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0000250" FT CHAIN 2..103 FT /note="Histone H4" FT /id="PRO_0000158351" FT DNA_BIND 17..21 FT REGION 1..20 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..14 FT /note="Gly residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 2 FT /note="N-acetylserine" FT /evidence="ECO:0000250" FT MOD_RES 6 FT /note="N6-acetyl-N6-methyllysine; alternate" FT /evidence="ECO:0000250|UniProtKB:P62805" FT MOD_RES 6 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250" FT MOD_RES 9 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250" FT MOD_RES 13 FT /note="N6-acetyl-N6-methyllysine; alternate" FT /evidence="ECO:0000250|UniProtKB:P62805" FT MOD_RES 13 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250" FT MOD_RES 17 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250" FT MOD_RES 21 FT /note="N6-methylated lysine" FT /evidence="ECO:0000250" SQ SEQUENCE 103 AA; 11367 MW; A9E5DFD3F8B97598 CRC64; MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG FGG //