ID   TBP_PYRWO               Reviewed;         191 AA.
AC   P62001; Q57050;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   02-SEP-2026, entry version 86.
DE   RecName: Full=TATA-box-binding protein;
DE   AltName: Full=Box A-binding protein;
DE            Short=BAP;
DE   AltName: Full=TATA sequence-binding protein;
DE            Short=TBP;
DE   AltName: Full=TATA-box factor;
GN   Name=tbp;
OS   Pyrococcus woesei.
OC   Archaea; Methanobacteriati; Methanobacteriota; Thermococci; Thermococcales;
OC   Thermococcaceae; Pyrococcus.
OX   NCBI_TaxID=2262;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8191287; DOI=10.1126/science.8191287;
RA   Rowlands T.M., Baumann P., Jackson S.P.;
RT   "The TATA-binding protein: a general transcription factor in eukaryotes and
RT   archaebacteria.";
RL   Science 264:1326-1329(1994).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
RX   PubMed=9000631; DOI=10.1006/jmbi.1996.0697;
RA   DeDecker B.S., O'Brien R., Fleming P.J., Geiger J.H., Jackson S.P.,
RA   Sigler P.B.;
RT   "The crystal structure of a hyperthermophilic archaeal TATA-box binding
RT   protein.";
RL   J. Mol. Biol. 264:1072-1084(1996).
CC   -!- FUNCTION: General factor that plays a role in the activation of
CC       archaeal genes transcribed by RNA polymerase. Binds specifically to the
CC       TATA box promoter element which lies close to the position of
CC       transcription initiation.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR   EMBL; U10285; AAA73447.1; -; Unassigned_DNA.
DR   PIR; A54275; A54275.
DR   RefSeq; WP_011012439.1; NZ_AP042435.1.
DR   PDB; 1AIS; X-ray; 2.10 A; A=1-181.
DR   PDB; 1D3U; X-ray; 2.40 A; A=1-181.
DR   PDB; 1PCZ; X-ray; 2.20 A; A/B=1-191.
DR   AlphaFoldDB; P62001; -.
DR   SMR; P62001; -.
DR   GeneID; 13301894; -.
DR   EvolutionaryTrace; P62001; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR   CDD; cd04518; TBP_archaea; 1.
DR   FunFam; 3.30.310.10:FF:000007; TATA-box-binding protein; 1.
DR   FunFam; 3.30.310.10:FF:000010; TATA-box-binding protein; 1.
DR   Gene3D; 3.30.310.10; TATA-Binding Protein; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR033711; TBP_archaea.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   NCBIfam; NF001593; PRK00394.1-2; 1.
DR   NCBIfam; NF001594; PRK00394.1-3; 1.
DR   PANTHER; PTHR10126; TATA-BOX BINDING PROTEIN; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   SUPFAM; SSF55945; TATA-box binding protein-like; 2.
DR   PROSITE; PS00351; TFIID; 2.
DR   PDBsum; 1AIS; -.
DR   PDBsum; 1D3U; -.
DR   PDBsum; 1PCZ; -.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..191
FT                   /note="TATA-box-binding protein"
FT                   /id="PRO_0000154023"
FT   REPEAT          11..87
FT                   /note="1"
FT   REPEAT          102..178
FT                   /note="2"
FT   HELIX           4..6
FT                   /evidence="ECO:0007829|PDB:1PCZ"
FT   STRAND          8..19
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   HELIX           26..29
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   TURN            30..32
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   STRAND          34..39
FT                   /evidence="ECO:0007829|PDB:1D3U"
FT   TURN            40..42
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   STRAND          44..49
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   STRAND          51..53
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   STRAND          56..59
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   STRAND          63..72
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   HELIX           73..89
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   STRAND          95..97
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   STRAND          99..110
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   HELIX           117..123
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   STRAND          127..130
FT                   /evidence="ECO:0007829|PDB:1PCZ"
FT   TURN            131..133
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   STRAND          135..141
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   TURN            142..145
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   STRAND          146..150
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   STRAND          154..163
FT                   /evidence="ECO:0007829|PDB:1AIS"
FT   HELIX           164..178
FT                   /evidence="ECO:0007829|PDB:1AIS"
SQ   SEQUENCE   191 AA;  21312 MW;  B371491BF9282972 CRC64;
     MVDMSKVKLR IENIVASVDL FAQLDLEKVL DLCPNSKYNP EEFPGIICHL DDPKVALLIF
     SSGKLVVTGA KSVQDIERAV AKLAQKLKSI GVKFKRAPQI DVQNMVFSGD IGREFNLDVV
     ALTLPNCEYE PEQFPGVIYR VKEPKSVILL FSSGKIVCSG AKSEADAWEA VRKLLRELDK
     YGLLEEEEEE L
//