ID   NEMS_DROME              Reviewed;         100 AA.
AC   P61849; P41494; Q9VC91;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   02-SEP-2026, entry version 114.
DE   RecName: Full=Dromyosuppressin {ECO:0000303|PubMed:12171930};
DE   AltName: Full=TDVDHVFLRFamide {ECO:0000303|PubMed:1390001};
DE   Flags: Precursor;
GN   Name=Ms {ECO:0000312|FlyBase:FBgn0011581};
GN   ORFNames=CG6440 {ECO:0000312|FlyBase:FBgn0011581};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota;
OC   Aparaglossata; Panorpida; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Ovary;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [4]
RP   PROTEIN SEQUENCE OF 87-96.
RX   PubMed=1390001; DOI=10.1007/bf03380141;
RA   Nichols R.;
RT   "Isolation and structural characterization of Drosophila TDVDHVFLRFamide
RT   and FMRFamide-containing neural peptides.";
RL   J. Mol. Neurosci. 3:213-218(1992).
RN   [5]
RP   PROTEIN SEQUENCE OF 87-96, AND AMIDATION AT PHE-96.
RC   TISSUE=Larva;
RX   PubMed=12171930; DOI=10.1074/jbc.m206257200;
RA   Baggerman G., Cerstiaens A., De Loof A., Schoofs L.;
RT   "Peptidomics of the larval Drosophila melanogaster central nervous
RT   system.";
RL   J. Biol. Chem. 277:40368-40374(2002).
CC   -!- FUNCTION: Myoinhibiting neuropeptide.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the myosuppressin family. {ECO:0000305}.
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DR   EMBL; AE014297; AAF56283.1; -; Genomic_DNA.
DR   EMBL; AY075325; AAL68192.1; -; mRNA.
DR   RefSeq; NP_001262911.1; NM_001275982.1.
DR   RefSeq; NP_001287503.1; NM_001300574.1.
DR   RefSeq; NP_536772.1; NM_080511.3.
DR   AlphaFoldDB; P61849; -.
DR   FunCoup; P61849; 94.
DR   STRING; 7227.FBpp0312058; -.
DR   PaxDb; 7227-FBpp0312058; -.
DR   PeptideAtlas; P61849; -.
DR   DNASU; 44324; -.
DR   EnsemblMetazoa; FBtr0084607; FBpp0083991; FBgn0011581.
DR   EnsemblMetazoa; FBtr0334600; FBpp0306667; FBgn0011581.
DR   EnsemblMetazoa; FBtr0346341; FBpp0312058; FBgn0011581.
DR   GeneID; 44324; -.
DR   KEGG; dme:Dmel_CG6440; -.
DR   UCSC; CG6440-RA; d. melanogaster.
DR   AGR; FB:FBgn0011581; -.
DR   CTD; 44324; -.
DR   FlyBase; FBgn0011581; Ms.
DR   VEuPathDB; VectorBase:FBgn0011581; -.
DR   eggNOG; ENOG502SDA3; Eukaryota.
DR   HOGENOM; CLU_177213_0_0_1; -.
DR   InParanoid; P61849; -.
DR   OMA; HIKKVCM; -.
DR   OrthoDB; 6355109at2759; -.
DR   PhylomeDB; P61849; -.
DR   BioGRID-ORCS; 44324; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 44324; -.
DR   PRO; PR:P61849; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0011581; Expressed in adult capability neuron in brain and 74 other cell types or tissues.
DR   ExpressionAtlas; P61849; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IDA:FlyBase.
DR   GO; GO:0005184; F:neuropeptide hormone activity; TAS:FlyBase.
DR   GO; GO:0071855; F:neuropeptide receptor binding; IPI:FlyBase.
DR   GO; GO:0008344; P:adult locomotory behavior; IMP:FlyBase.
DR   GO; GO:0060457; P:negative regulation of digestive system process; IDA:FlyBase.
DR   GO; GO:0045822; P:negative regulation of heart contraction; IDA:FlyBase.
DR   GO; GO:0010459; P:negative regulation of heart rate; IDA:FlyBase.
DR   GO; GO:0045986; P:negative regulation of smooth muscle contraction; IDA:FlyBase.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IDA:FlyBase.
DR   InterPro; IPR062014; Myosuppressin.
DR   Pfam; PF28905; Myosuppressin; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..84
FT                   /id="PRO_0000021797"
FT   PEPTIDE         87..96
FT                   /note="Dromyosuppressin"
FT                   /id="PRO_0000021798"
FT   MOD_RES         96
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:12171930"
SQ   SEQUENCE   100 AA;  11070 MW;  177CBFA528D8BE58 CRC64;
     MSFAQFFVAC CLAIVLLAVS NTRAAVQGPP LCQSGIVEEM PPHIRKVCQA LENSDQLTSA
     LKSYINNEAS ALVANSDDLL KNYNKRTDVD HVFLRFGKRR
//