ID   T2R41_HUMAN             Reviewed;         307 AA.
AC   P59536; P59550; Q495I2; Q50KJ5; Q50KJ6; Q50KJ7; Q645W7;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 2.
DT   02-SEP-2026, entry version 153.
DE   RecName: Full=Taste receptor type 2 member 41;
DE            Short=T2R41;
DE   AltName: Full=Taste receptor type 2 member 59;
DE            Short=T2R59;
GN   Name=TAS2R41;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12584440; DOI=10.1159/000068546;
RA   Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
RT   "Identification and characterization of human taste receptor genes
RT   belonging to the TAS2R family.";
RL   Cytogenet. Genome Res. 98:45-53(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LEU-127.
RX   PubMed=12379855; DOI=10.1038/ng1014;
RA   Bufe B., Hofmann T., Krautwurst D., Raguse J.-D., Meyerhof W.;
RT   "The human TAS2R16 receptor mediates bitter taste in response to beta-
RT   glucopyranosides.";
RL   Nat. Genet. 32:397-401(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LEU-127.
RX   PubMed=15496549; DOI=10.1093/molbev/msi027;
RA   Fischer A., Gilad Y., Man O., Paeaebo S.;
RT   "Evolution of bitter taste receptors in humans and apes.";
RL   Mol. Biol. Evol. 22:432-436(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-291.
RX   PubMed=15744053; DOI=10.1534/genetics.104.037523;
RA   Go Y., Satta Y., Takenaka O., Takahata N.;
RT   "Lineage-specific loss of function of bitter taste receptor genes in humans
RT   and nonhuman primates.";
RL   Genetics 170:313-326(2005).
RN   [7]
RP   REVIEW.
RX   PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA   Montmayeur J.-P., Matsunami H.;
RT   "Receptors for bitter and sweet taste.";
RL   Curr. Opin. Neurobiol. 12:366-371(2002).
RN   [8]
RP   REVIEW.
RX   PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA   Margolskee R.F.;
RT   "Molecular mechanisms of bitter and sweet taste transduction.";
RL   J. Biol. Chem. 277:1-4(2002).
RN   [9]
RP   REVIEW.
RX   PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA   Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA   Zuker C.S., Ryba N.J.;
RT   "Coding of sweet, bitter, and umami tastes: different receptor cells
RT   sharing similar signaling pathways.";
RL   Cell 112:293-301(2003).
CC   -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC       and is gustducin-linked. May play a role in sensing the chemical
CC       composition of the gastrointestinal content. The activity of this
CC       receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC       and lead to the gating of TRPM5 (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       P59536; Q6ICB0: DESI1; NbExp=3; IntAct=EBI-13344991, EBI-2806959;
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC       tongue and exclusively in gustducin-positive cells.
CC   -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC       bitter compounds; individual taste cells can discriminate among bitter
CC       stimuli.
CC   -!- SIMILARITY: Belongs to the G protein-coupled receptor T2R family.
CC       {ECO:0000305}.
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DR   EMBL; AY114093; AAM63543.1; -; Genomic_DNA.
DR   EMBL; AF494232; AAM19323.1; -; Genomic_DNA.
DR   EMBL; AY724956; AAU21152.1; -; Genomic_DNA.
DR   EMBL; AC073264; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC101157; AAI01158.1; -; mRNA.
DR   EMBL; BC101158; AAI01159.1; -; mRNA.
DR   EMBL; AB199177; BAD98051.1; -; Genomic_DNA.
DR   EMBL; AB199178; BAD98052.1; -; Genomic_DNA.
DR   EMBL; AB199179; BAD98053.1; -; Genomic_DNA.
DR   CCDS; CCDS43663.1; -.
DR   RefSeq; NP_795364.2; NM_176883.2.
DR   AlphaFoldDB; P59536; -.
DR   SMR; P59536; -.
DR   BioGRID; 129242; 22.
DR   FunCoup; P59536; 347.
DR   IntAct; P59536; 17.
DR   STRING; 9606.ENSP00000386201; -.
DR   BindingDB; P59536; -.
DR   ChEMBL; CHEMBL3309108; -.
DR   DrugCentral; P59536; -.
DR   GlyCosmos; P59536; 1 site, No reported glycans.
DR   GlyGen; P59536; 1 site.
DR   iPTMnet; P59536; -.
DR   PhosphoSitePlus; P59536; -.
DR   BioMuta; TAS2R41; -.
DR   DMDM; 261260079; -.
DR   PaxDb; 9606-ENSP00000386201; -.
DR   PeptideAtlas; P59536; -.
DR   Antibodypedia; 32664; 101 antibodies from 19 providers.
DR   DNASU; 259287; -.
DR   Ensembl; ENST00000408916.1; ENSP00000386201.1; ENSG00000221855.1.
DR   Ensembl; ENST00000646750.1; ENSP00000494656.1; ENSG00000284982.1.
DR   GeneID; 259287; -.
DR   KEGG; hsa:259287; -.
DR   MANE-Select; ENST00000408916.1; ENSP00000386201.1; NM_176883.2; NP_795364.2.
DR   UCSC; uc003wdc.1; human.
DR   AGR; HGNC:18883; -.
DR   ClinPGx; PA38737; -.
DR   CTD; 259287; -.
DR   GeneCards; TAS2R41; -.
DR   HGNC; HGNC:18883; TAS2R41.
DR   HPA; ENSG00000221855; Not detected.
DR   MIM; 613965; gene.
DR   VEuPathDB; HostDB:ENSG00000221855; -.
DR   eggNOG; ENOG502S2SI; Eukaryota.
DR   GeneTree; ENSGT01150000286961; -.
DR   HOGENOM; CLU_072337_1_1_1; -.
DR   InParanoid; P59536; -.
DR   OMA; FCLQWVG; -.
DR   OrthoDB; 9896661at2759; -.
DR   PAN-GO; P59536; 1 GO annotation based on evolutionary models.
DR   PhylomeDB; P59536; -.
DR   PathwayCommons; P59536; -.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR   Reactome; R-HSA-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR   SignaLink; P59536; -.
DR   Agora; ENSG00000221855; -.
DR   BioGRID-ORCS; 259287; 9 hits in 1138 CRISPR screens.
DR   GeneWiki; TAS2R41; -.
DR   GenomeRNAi; 259287; -.
DR   Pharos; P59536; Tchem.
DR   PRO; PR:P59536; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; P59536; protein.
DR   Bgee; ENSG00000221855; Expressed in hindlimb stylopod muscle.
DR   GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:InterPro.
DR   CDD; cd15018; 7tm_TAS2R41-like; 1.
DR   FunFam; 1.20.1070.10:FF:000055; Taste receptor type 2; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR007960; TAS2R.
DR   PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR   PANTHER; PTHR11394:SF73; TASTE RECEPTOR TYPE 2 MEMBER 41; 1.
DR   Pfam; PF05296; TAS2R; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE   1: Evidence at protein level;
KW   G protein-coupled receptor; Glycoprotein; Membrane;
KW   Proteomics identification; Receptor; Reference proteome;
KW   Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..307
FT                   /note="Taste receptor type 2 member 41"
FT                   /id="PRO_0000082295"
FT   TOPO_DOM        1..7
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..40
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        62..88
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        110..129
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        151..183
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..264
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        286..307
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        167
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         127
FT                   /note="P -> L (in dbSNP:rs10278721)"
FT                   /evidence="ECO:0000269|PubMed:12379855,
FT                   ECO:0000269|PubMed:15496549"
FT                   /id="VAR_060211"
FT   CONFLICT        207
FT                   /note="L -> M (in Ref. 6; BAD98053)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   307 AA;  35896 MW;  7A33E3ED3E44E563 CRC64;
     MQAALTAFFV LLFSLLSLLG IAANGFIVLV LGREWLRYGR LLPLDMILIS LGASRFCLQL
     VGTVHNFYYS AQKVEYSGGL GRQFFHLHWH FLNSATFWFC SWLSVLFCVK IANITHSTFL
     WLKWRFPGWV PWLLLGSVLI SFIITLLFFW VNYPVYQEFL IRKFSGNMTY KWNTRIETYY
     FPSLKLVIWS IPFSVFLVSI MLLINSLRRH TQRMQHNGHS LQDPSTQAHT RALKSLISFL
     ILYALSFLSL IIDAAKFISM QNDFYWPWQI AVYLCISVHP FILIFSNLKL RSVFSQLLLL
     ARGFWVA
//