ID   YCIB_BRUSU              Reviewed;         200 AA.
AC   P59363; G0K878;
DT   28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   07-NOV-2003, sequence version 2.
DT   02-SEP-2026, entry version 105.
DE   RecName: Full=Inner membrane-spanning protein YciB {ECO:0000255|HAMAP-Rule:MF_00189};
GN   Name=yciB {ECO:0000255|HAMAP-Rule:MF_00189};
GN   OrderedLocusNames=BR1935, BS1330_I1929;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC   Hyphomicrobiales; Brucellaceae; Brucella/Ochrobactrum group; Brucella;
OC   Brucella melitensis group.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
CC   -!- FUNCTION: Plays a role in cell envelope biogenesis, maintenance of cell
CC       envelope integrity and membrane homeostasis. {ECO:0000255|HAMAP-
CC       Rule:MF_00189}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00189}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00189}.
CC   -!- SIMILARITY: Belongs to the YciB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00189}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN30827.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AEM19244.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE014291; AAN30827.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP002997; AEM19244.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P59363; -.
DR   KEGG; bms:BR1935; -.
DR   KEGG; bsi:BS1330_I1929; -.
DR   HOGENOM; CLU_089554_1_1_5; -.
DR   Proteomes; UP000007104; Chromosome I.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_00189; YciB; 1.
DR   InterPro; IPR006008; YciB.
DR   NCBIfam; TIGR00997; ispZ; 1.
DR   NCBIfam; NF001323; PRK00259.1-1; 1.
DR   PANTHER; PTHR36917:SF1; INNER MEMBRANE-SPANNING PROTEIN YCIB; 1.
DR   PANTHER; PTHR36917; INTRACELLULAR SEPTATION PROTEIN A-RELATED; 1.
DR   Pfam; PF04279; IspA; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..200
FT                   /note="Inner membrane-spanning protein YciB"
FT                   /id="PRO_0000206526"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00189"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00189"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00189"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00189"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00189"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00189"
SQ   SEQUENCE   200 AA;  22356 MW;  F1A1E43A21170DEA CRC64;
     MPPLLKLALE LGPLLVFFFA NARGEMLIER FPILGSIGAP IFLATALFMA ATVIALAISW
     SMTRTLPIMP LVSGIVVLVF GALTLWLHND TFIKMKPTIV NTLFGGILLG GLFFGKSLLG
     YVFDSAFRLD AEGWRKLTLR WGLFFIFLAI VNEIVWRNFS TDTWVSFKVW GIMPITIVFT
     LLQMPLIQKH SLTDEENTAS
//