ID   CU058_HUMAN             Reviewed;         322 AA.
AC   P58505; B3KPI1; Q8N7N9;
DT   19-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   02-SEP-2026, entry version 151.
DE   RecName: Full=Uncharacterized protein C21orf58;
GN   Name=C21orf58;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 39-322 (ISOFORMS 1 AND 2).
RX   PubMed=11707072; DOI=10.1006/geno.2001.6640;
RA   Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S.,
RA   Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.;
RT   "From PREDs and open reading frames to cDNA isolation: revisiting the human
RT   chromosome 21 transcription map.";
RL   Genomics 78:46-54(2001).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=P58505-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P58505-2; Sequence=VSP_003827, VSP_003828;
CC       Name=3;
CC         IsoId=P58505-3; Sequence=VSP_057984;
CC   -!- TISSUE SPECIFICITY: Expressed in skin and fetal lung.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK72408.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAK72409.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK098098; BAC05232.1; -; mRNA.
DR   EMBL; AK056387; BAG51693.1; -; mRNA.
DR   EMBL; AP000471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY039243; AAK72408.1; ALT_INIT; mRNA.
DR   EMBL; AY039244; AAK72409.1; ALT_INIT; mRNA.
DR   CCDS; CCDS13735.1; -. [P58505-1]
DR   CCDS; CCDS68229.1; -. [P58505-3]
DR   RefSeq; NP_001273391.1; NM_001286462.2. [P58505-3]
DR   RefSeq; NP_001273392.1; NM_001286463.1. [P58505-3]
DR   RefSeq; NP_001273405.1; NM_001286476.2. [P58505-3]
DR   RefSeq; NP_001273406.1; NM_001286477.2. [P58505-3]
DR   RefSeq; NP_478060.2; NM_058180.5. [P58505-1]
DR   RefSeq; XP_005261205.1; XM_005261148.6. [P58505-1]
DR   RefSeq; XP_006724081.1; XM_006724018.5. [P58505-2]
DR   RefSeq; XP_011527921.1; XM_011529619.4. [P58505-1]
DR   RefSeq; XP_011527922.1; XM_011529620.4. [P58505-1]
DR   RefSeq; XP_016883881.1; XM_017028392.2. [P58505-3]
DR   RefSeq; XP_016883882.1; XM_017028393.2. [P58505-3]
DR   RefSeq; XP_054180612.1; XM_054324637.1. [P58505-1]
DR   RefSeq; XP_054180613.1; XM_054324638.1. [P58505-1]
DR   RefSeq; XP_054180614.1; XM_054324639.1. [P58505-1]
DR   RefSeq; XP_054180618.1; XM_054324643.1. [P58505-2]
DR   RefSeq; XP_054180626.1; XM_054324651.1. [P58505-3]
DR   RefSeq; XP_054180627.1; XM_054324652.1. [P58505-3]
DR   AlphaFoldDB; P58505; -.
DR   SMR; P58505; -.
DR   BioGRID; 119868; 24.
DR   FunCoup; P58505; 44.
DR   IntAct; P58505; 6.
DR   MINT; P58505; -.
DR   STRING; 9606.ENSP00000291691; -.
DR   GlyGen; P58505; 1 site.
DR   iPTMnet; P58505; -.
DR   PhosphoSitePlus; P58505; -.
DR   BioMuta; C21orf58; -.
DR   DMDM; 215274005; -.
DR   MassIVE; P58505; -.
DR   PaxDb; 9606-ENSP00000291691; -.
DR   PeptideAtlas; P58505; -.
DR   Antibodypedia; 24660; 70 antibodies from 19 providers.
DR   DNASU; 54058; -.
DR   Ensembl; ENST00000291691.12; ENSP00000291691.8; ENSG00000160298.19. [P58505-1]
DR   Ensembl; ENST00000397679.5; ENSP00000380796.1; ENSG00000160298.19. [P58505-3]
DR   Ensembl; ENST00000397680.5; ENSP00000380797.1; ENSG00000160298.19. [P58505-3]
DR   Ensembl; ENST00000397682.7; ENSP00000380798.3; ENSG00000160298.19. [P58505-3]
DR   Ensembl; ENST00000397683.5; ENSP00000380799.1; ENSG00000160298.19. [P58505-3]
DR   GeneID; 54058; -.
DR   KEGG; hsa:54058; -.
DR   MANE-Select; ENST00000291691.12; ENSP00000291691.8; NM_058180.5; NP_478060.2.
DR   UCSC; uc002zja.3; human.
DR   UCSC; uc002zjf.5; human. [P58505-1]
DR   AGR; HGNC:1300; -.
DR   ClinPGx; PA25853; -.
DR   CTD; 54058; -.
DR   DisGeNET; 54058; -.
DR   GeneCards; C21orf58; -.
DR   HGNC; HGNC:1300; C21orf58.
DR   HPA; ENSG00000160298; Tissue enhanced (fallopian tube, pituitary gland).
DR   OpenTargets; ENSG00000160298; -.
DR   VEuPathDB; HostDB:ENSG00000160298; -.
DR   eggNOG; ENOG502QV5Q; Eukaryota.
DR   GeneTree; ENSGT00390000011514; -.
DR   InParanoid; P58505; -.
DR   OMA; LKPHHIY; -.
DR   OrthoDB; 8962708at2759; -.
DR   PAN-GO; P58505; 0 GO annotations based on evolutionary models.
DR   PhylomeDB; P58505; -.
DR   PathwayCommons; P58505; -.
DR   SignaLink; P58505; -.
DR   Agora; ENSG00000160298; -.
DR   BioGRID-ORCS; 54058; 14 hits in 1127 CRISPR screens.
DR   ChiTaRS; C21orf58; human.
DR   GenomeRNAi; 54058; -.
DR   Pharos; P58505; Tdark.
DR   PRO; PR:P58505; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; P58505; protein.
DR   Bgee; ENSG00000160298; Expressed in right uterine tube and 104 other cell types or tissues.
DR   ExpressionAtlas; P58505; baseline and differential.
DR   InterPro; IPR027904; DUF4587.
DR   InterPro; IPR038915; PRR29-like.
DR   PANTHER; PTHR28604; -; 1.
DR   PANTHER; PTHR28604:SF2; RIKEN CDNA 2610028H24 GENE; 1.
DR   Pfam; PF15248; DUF4587; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Proteomics identification; Reference proteome.
FT   CHAIN           1..322
FT                   /note="Uncharacterized protein C21orf58"
FT                   /id="PRO_0000079521"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..130
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..148
FT                   /note="MARSRLPATSLRKPWKLDRQKLPSPDSGHSLLCGWSPGGKARPAGNTGAWAP
FT                   AEQFFPASNRTREGGGLWPPLPLQSSPAAPTMLDSSAAEQVTRLTLKLLGQKLEQERQN
FT                   VEGGPEGLHLEPGNEDRPDDALQTALKRRRDLLQRLR -> MAILPGEAPVPGPGWPEP
FT                   DAGGASVALGLPVPVCSSSASALQ (in isoform 3)"
FT                   /id="VSP_057984"
FT   VAR_SEQ         273..277
FT                   /note="PPHVP -> RFFHS (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11707072"
FT                   /id="VSP_003827"
FT   VAR_SEQ         278..322
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11707072"
FT                   /id="VSP_003828"
FT   CONFLICT        111
FT                   /note="N -> D (in Ref. 1; BAG51693)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   322 AA;  35003 MW;  06DB0577FFAD57D6 CRC64;
     MARSRLPATS LRKPWKLDRQ KLPSPDSGHS LLCGWSPGGK ARPAGNTGAW APAEQFFPAS
     NRTREGGGLW PPLPLQSSPA APTMLDSSAA EQVTRLTLKL LGQKLEQERQ NVEGGPEGLH
     LEPGNEDRPD DALQTALKRR RDLLQRLREQ HLLDELSRAQ AWSGPSRGAL GSALPPELPP
     TGILPTASPS PLAPDPPRII LPTVPQPPAT IIQQLPQQPL IAQIPPPQAF PTQRSGSIKE
     DMVELLLLQN AQVHQLVLQN WMLKALPPAL QDPPHVPPRV PRAARPRLPA VHHHHHHHHA
     VWPPGAATVL QPAPSLWTPG PP
//