ID   RRP1_MOUSE              Reviewed;         494 AA.
AC   P56183; O35712; Q9ERE1; Q9JI07; Q9JK67; Q9JKU2;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2002, sequence version 2.
DT   04-NOV-2026, entry version 159.
DE   RecName: Full=Ribosomal RNA processing protein 1 homolog A;
DE   AltName: Full=Novel nuclear protein 1;
DE            Short=NNP-1;
DE   AltName: Full=Nucleolar protein Nop52;
DE   AltName: Full=RRP1-like protein;
GN   Name=Rrp1; Synonyms=Nnp1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND DEVELOPMENTAL STAGE.
RC   TISSUE=Pituitary;
RX   PubMed=9192856; DOI=10.1006/geno.1997.4755;
RA   Jansen E., Meulemans S.M.P., Orlans I.C.R., Van de Ven W.J.M.;
RT   "The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in
RT   close proximity to the cystatin B gene within the EPM1 and APECED critical
RT   region on 21q22.3.";
RL   Genomics 42:336-341(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=129/Ola; TISSUE=Spleen;
RA   Tsyba L., Skripkina I., Anoprienko O., Kvasha S., Slavov D., Tassone F.,
RA   Rynditch A., Gardiner K.;
RT   "Mouse homologues of human chromosome 21 genes.";
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Kidney, Liver, Lung, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Plays a critical role in the generation of 28S rRNA.
CC       {ECO:0000250|UniProtKB:P56182}.
CC   -!- SUBUNIT: Interacts with C1QBP. Interacts with RRP1B.
CC       {ECO:0000250|UniProtKB:P56182}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:P56182}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=P56183-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P56183-2; Sequence=VSP_004335, VSP_004336;
CC       Name=3;
CC         IsoId=P56183-3; Sequence=VSP_004337;
CC   -!- DEVELOPMENTAL STAGE: Embryonic, expression starting between days 1 and
CC       10. {ECO:0000269|PubMed:9192856}.
CC   -!- SIMILARITY: Belongs to the RRP1 family. {ECO:0000305}.
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DR   EMBL; U79773; AAC53286.1; -; mRNA.
DR   EMBL; U79774; AAB63261.1; -; mRNA.
DR   EMBL; AF294729; AAF76216.2; -; Genomic_DNA.
DR   EMBL; AF312394; AAG30293.1; -; mRNA.
DR   EMBL; BC065993; AAH65993.1; -; mRNA.
DR   EMBL; BC065994; AAH65994.1; -; mRNA.
DR   CCDS; CCDS35961.1; -. [P56183-1]
DR   RefSeq; NP_035055.2; NM_010925.3. [P56183-1]
DR   AlphaFoldDB; P56183; -.
DR   SMR; P56183; -.
DR   BioGRID; 201798; 24.
DR   CORUM; P56183; -.
DR   FunCoup; P56183; 2483.
DR   STRING; 10090.ENSMUSP00000058785; -.
DR   iPTMnet; P56183; -.
DR   PhosphoSitePlus; P56183; -.
DR   SwissPalm; P56183; -.
DR   jPOST; P56183; -.
DR   PaxDb; 10090-ENSMUSP00000058785; -.
DR   PeptideAtlas; P56183; -.
DR   ProteomicsDB; 260849; -. [P56183-1]
DR   ProteomicsDB; 260850; -. [P56183-2]
DR   ProteomicsDB; 260851; -. [P56183-3]
DR   Pumba; P56183; -.
DR   Antibodypedia; 5231; 195 antibodies from 28 providers.
DR   DNASU; 18114; -.
DR   Ensembl; ENSMPUT00000009909; ENSMPUP00000009752; ENSMPUG00000009826.
DR   Ensembl; ENSMUST00000062678.11; ENSMUSP00000058785.10; ENSMUSG00000061032.10. [P56183-1]
DR   GeneID; 18114; -.
DR   KEGG; mmu:18114; -.
DR   UCSC; uc007fxs.1; mouse. [P56183-1]
DR   AGR; MGI:1203500; -.
DR   CTD; 8568; -.
DR   MGI; MGI:1203500; Rrp1.
DR   VEuPathDB; HostDB:ENSMUSG00000061032; -.
DR   eggNOG; KOG3911; Eukaryota.
DR   GeneTree; ENSGT00390000011821; -.
DR   HOGENOM; CLU_022876_2_0_1; -.
DR   InParanoid; P56183; -.
DR   OMA; ACDQYNT; -.
DR   OrthoDB; 2019504at2759; -.
DR   PhylomeDB; P56183; -.
DR   BioGRID-ORCS; 18114; 30 hits in 80 CRISPR screens.
DR   PRO; PR:P56183; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; P56183; protein.
DR   Bgee; ENSMUSG00000061032; Expressed in dentate gyrus of hippocampal formation granule cell and 273 other cell types or tissues.
DR   ExpressionAtlas; P56183; baseline and differential.
DR   GO; GO:0005694; C:chromosome; ISO:GO_Central.
DR   GO; GO:0005730; C:nucleolus; ISO:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; IEA:InterPro.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR   InterPro; IPR010301; RRP1.
DR   PANTHER; PTHR13026; NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52; 1.
DR   PANTHER; PTHR13026:SF1; RIBOSOMAL RNA PROCESSING PROTEIN 1 HOMOLOG A; 1.
DR   Pfam; PF05997; Nop52; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Nucleus; Phosphoprotein; Reference proteome;
KW   rRNA processing.
FT   CHAIN           1..494
FT                   /note="Ribosomal RNA processing protein 1 homolog A"
FT                   /id="PRO_0000096888"
FT   REGION          239..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          388..494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..304
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        332..341
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        401..413
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..423
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         254
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P56182"
FT   MOD_RES         434
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         455
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P56182"
FT   VAR_SEQ         245..258
FT                   /note="ASDGDDGEASDGDD -> GSDEDDGDDDSDEA (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:9192856"
FT                   /id="VSP_004335"
FT   VAR_SEQ         259..309
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:9192856"
FT                   /id="VSP_004336"
FT   VAR_SEQ         450..484
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_004337"
FT   CONFLICT        50
FT                   /note="D -> C (in Ref. 2; AAG30293)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   494 AA;  54777 MW;  9866F1BD7AE3E99D CRC64;
     MVPGVPLPPE IQLAQRLAGN EQVTRDRALR KLRKYIEARS QRATGGFTPD ELLKVWKGLF
     YCMWMQDKPL QQEELGRTIA QLVHAFHTTE AQHQFLKAFW QTMIREWVGI DRLRLDKFYM
     LMRMVLSESL KAVKARGWDE RQIEQLLELL TTEILNPDSQ APSGVKSHFL EIFLEELAKV
     GAAELTADQN LQFIDPFCQI AARTKDSQVL HKIIQSIFQT IVEQAPLAIE DIMNELDTQS
     GEGEASDGDD GEASDGDDGE ASDDDDGEAS DGGDGDVADS DDSDGADDDD GDVSDGDGGD
     NDEGDSNKSS EGEQDLQDTP PKKLPAGTAH RAGPEADKEQ AWDDEENAGP VLQFDYEALA
     NRLFKLASRQ STPSQNRKRL YKVIQKLREL AGGTFPEDDV PEKAYKKMLE GRRERKKKKK
     RLPKPQPQNK EAGSEAESSS ADPGPGRKRK RNRKTDEKAG QGGPPGKRRK PGARAKGAGA
     QQPKKRIQSS QSAE
//