ID   IF3_HELPY               Reviewed;         203 AA.
AC   P55973;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   02-SEP-2026, entry version 133.
DE   RecName: Full=Translation initiation factor IF-3 {ECO:0000255|HAMAP-Rule:MF_00080};
GN   Name=infC {ECO:0000255|HAMAP-Rule:MF_00080};
GN   OrderedLocusNames=HP_0124;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Pseudomonadati; Campylobacterota; Epsilonproteobacteria;
OC   Campylobacterales; Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: IF-3 binds to the 30S ribosomal subunit and shifts the
CC       equilibrium between 70S ribosomes and their 50S and 30S subunits in
CC       favor of the free subunits, thus enhancing the availability of 30S
CC       subunits on which protein synthesis initiation begins.
CC       {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00080}.
CC   -!- SIMILARITY: Belongs to the IF-3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00080}.
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DR   EMBL; AE000511; AAD07193.1; -; Genomic_DNA.
DR   PIR; D64535; D64535.
DR   RefSeq; WP_000089203.1; NC_018939.1.
DR   AlphaFoldDB; P55973; -.
DR   SMR; P55973; -.
DR   DIP; DIP-3195N; -.
DR   FunCoup; P55973; 379.
DR   IntAct; P55973; 2.
DR   MINT; P55973; -.
DR   STRING; 85962.HP_0124; -.
DR   PaxDb; 85962-HP_0124; -.
DR   EnsemblBacteria; AAD07193; AAD07193; HP_0124.
DR   KEGG; heo:C694_00615; -.
DR   KEGG; hpy:HP_0124; -.
DR   PATRIC; fig|85962.47.peg.134; -.
DR   eggNOG; COG0290; Bacteria.
DR   InParanoid; P55973; -.
DR   OrthoDB; 9806014at2; -.
DR   PhylomeDB; P55973; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032790; P:ribosome disassembly; IBA:GO_Central.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   FunFam; 3.10.20.80:FF:000001; Translation initiation factor IF-3; 1.
DR   Gene3D; 3.30.110.10; Translation initiation factor 3 (IF-3), C-terminal domain; 1.
DR   Gene3D; 3.10.20.80; Translation initiation factor 3 (IF-3), N-terminal domain; 1.
DR   HAMAP; MF_00080; IF_3; 1.
DR   InterPro; IPR036788; T_IF-3_C_sf.
DR   InterPro; IPR036787; T_IF-3_N_sf.
DR   InterPro; IPR019813; Translation_initiation_fac3_CS.
DR   InterPro; IPR001288; Translation_initiation_fac_3.
DR   InterPro; IPR019815; Translation_initiation_fac_3_C.
DR   InterPro; IPR019814; Translation_initiation_fac_3_N.
DR   NCBIfam; TIGR00168; infC; 1.
DR   PANTHER; PTHR10938; TRANSLATION INITIATION FACTOR IF-3; 1.
DR   PANTHER; PTHR10938:SF0; TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL; 1.
DR   Pfam; PF00707; IF3_C; 1.
DR   Pfam; PF05198; IF3_N; 1.
DR   SUPFAM; SSF55200; Translation initiation factor IF3, C-terminal domain; 1.
DR   SUPFAM; SSF54364; Translation initiation factor IF3, N-terminal domain; 1.
DR   PROSITE; PS00938; IF3; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..203
FT                   /note="Translation initiation factor IF-3"
FT                   /id="PRO_0000177525"
FT   REGION          172..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   203 AA;  23342 MW;  65B38BFD36CD8003 CRC64;
     MSRNEVLLNG DINFKEVRCV GDNGEVYGII SSKEALHIAQ NLGLDLVLIS ASAKPPVCKV
     MDYNKFRYQN EKKIKEAKKK QKQIEIKEIK LSTQIAQNDI NYKVKHAREF IESNKHVKFK
     VVLKGRESQN SKAGLDVLFR VQTMMQDLAN PEKEPKTEGR FVSWMFVPKA KEAPKNEKKT
     KENNPPFNRI NLMKGENHAK NED
//