ID   HPAA_HELPY              Reviewed;         260 AA.
AC   P55969;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   02-SEP-2026, entry version 118.
DE   RecName: Full=Neuraminyllactose-binding hemagglutinin;
DE   AltName: Full=Flagellar sheath adhesin;
DE   AltName: Full=N-acetylneuraminyllactose-binding fibrillar hemagglutinin receptor-binding subunit;
DE            Short=NLBH;
DE   Flags: Precursor;
GN   Name=hpaA; OrderedLocusNames=HP_0797;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Pseudomonadati; Campylobacterota; Epsilonproteobacteria;
OC   Campylobacterales; Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
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DR   EMBL; AE000511; AAD07844.1; -; Genomic_DNA.
DR   PIR; E64619; E64619.
DR   RefSeq; WP_000646667.1; NC_018939.1.
DR   PDB; 8T8D; X-ray; 2.90 A; A/B/C/D=53-260.
DR   AlphaFoldDB; P55969; -.
DR   SMR; P55969; -.
DR   DIP; DIP-3518N; -.
DR   IntAct; P55969; 7.
DR   MINT; P55969; -.
DR   STRING; 85962.HP_0797; -.
DR   PaxDb; 85962-HP_0797; -.
DR   EnsemblBacteria; AAD07844; AAD07844; HP_0797.
DR   KEGG; heo:C694_04085; -.
DR   KEGG; hpy:HP_0797; -.
DR   PATRIC; fig|85962.47.peg.849; -.
DR   InParanoid; P55969; -.
DR   OrthoDB; 5328461at2; -.
DR   PhylomeDB; P55969; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.30.160.180; Putative neuraminyllactose-binding hemagglutinin homolog like domain; 1.
DR   InterPro; IPR007876; NeuraminylLac-bd_hemagglutn.
DR   InterPro; IPR038531; NeuraminylLac-bd_hemagglutn_sf.
DR   Pfam; PF05211; NLBH; 1.
DR   PIRSF; PIRSF019714; Neuraminyllac-bd_haemagglutn; 1.
DR   SUPFAM; SSF159594; XCC0632-like; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PDBsum; 8T8D; -.
PE   1: Evidence at protein level;
KW   3D-structure; Cell outer membrane; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           28..260
FT                   /note="Neuraminyllactose-binding hemagglutinin"
FT                   /id="PRO_0000018100"
FT   LIPID           28
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           28
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
FT   STRAND          57..60
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   HELIX           61..63
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   STRAND          64..67
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   HELIX           73..93
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   STRAND          97..100
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   HELIX           106..108
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   HELIX           111..116
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   STRAND          117..131
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   HELIX           133..135
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   STRAND          145..147
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   STRAND          154..169
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   TURN            171..173
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   STRAND          176..183
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   HELIX           184..186
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   STRAND          191..195
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   HELIX           200..202
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   HELIX           207..209
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   HELIX           216..238
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   HELIX           241..245
FT                   /evidence="ECO:0007829|PDB:8T8D"
FT   HELIX           248..260
FT                   /evidence="ECO:0007829|PDB:8T8D"
SQ   SEQUENCE   260 AA;  29040 MW;  D9F86C8B0556D071 CRC64;
     MKANNHFKDF AWKKCLLGAS VVALLVGCSP HIIETNEVAL KLNYHPASEK VQALDEKILL
     LRPAFQYSDN IAKEYENKFK NQTALKVEQI LQNQGYKVIS VDSSDKDDLS FSQKKEGYLA
     VAMNGEIVLR PDPKRTIQKK SEPGLLFSTG LDKMEGVLIP AGFVKVTILE PMSGESLDSF
     TMDLSELDIQ EKFLKTTHSS HSGGLVSTMV KGTDNSNDAI KSALNKIFAN IMQEIDKKLT
     QKNLESYQKD AKELKGKRNR
//