ID   AROF_STRLI              Reviewed;         146 AA.
AC   P55911;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   02-SEP-2026, entry version 79.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase;
DE            EC=2.5.1.54;
DE   AltName: Full=3-deoxy-D-arabino-heptulosonate 7-phosphate synthase;
DE   AltName: Full=DAHP synthase;
DE   AltName: Full=Phospho-2-keto-3-deoxyheptonate aldolase;
DE   Flags: Fragment;
OS   Streptomyces lividans.
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TK64;
RA   Liaw L.L., Su M.H., Lee Y.H.W.;
RL   Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION, AND CONCEPTUAL TRANSLATION.
RX   PubMed=8760910; DOI=10.1099/13500872-142-8-1973;
RA   Walker G.E., Dunbar B., Hunter I.S., Nimmo H.G., Coggins J.R.;
RT   "Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-
RT   phosphate synthase in Streptomyces coelicolor A3(2), Streptomyces rimosus
RT   and Neurospora crassa.";
RL   Microbiology 142:1973-1982(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-II DAHP synthase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=L13767; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; L13767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P55911; -.
DR   SMR; P55911; -.
DR   UniPathway; UPA00053; UER00084.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:InterPro.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002480; DAHP_synth_2.
DR   PANTHER; PTHR21337:SF0; PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE; 1.
DR   PANTHER; PTHR21337; PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2; 1.
DR   Pfam; PF01474; DAHP_synth_2; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
DR   PROSITE; PS52062; DAHPS_II; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Transferase.
FT   CHAIN           <1..146
FT                   /note="Phospho-2-dehydro-3-deoxyheptonate aldolase"
FT                   /id="PRO_0000140856"
FT   DOMAIN          1..146
FT                   /note="DAHPS class-II TIM-barrel"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01407"
FT   NON_TER         1
SQ   SEQUENCE   146 AA;  16589 MW;  1A837D3371EDC546 CRC64;
     LQYIERLDPE REPGRLTFIV RMGADKIRDK LPELVERSPP PATVAWITDP MHGNTYEAAP
     VHKTRRFDDV LDEVKGFFEV HKSLGTHPGG IHVELTGDDV TECVGGGDEI FVDDLHQRYE
     TACDPRLNRS QSLDLAFLVA EMYRDQ
//