ID   SH3BG_HUMAN             Reviewed;         239 AA.
AC   P55822; A6ND59; D3DSI2; Q9BRB8;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 3.
DT   02-SEP-2026, entry version 189.
DE   RecName: Full=SH3 domain-binding glutamic acid-rich protein;
DE            Short=SH3BGR protein;
DE   AltName: Full=21-glutamic acid-rich protein;
DE            Short=21-GARP;
GN   Name=SH3BGR;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Heart;
RX   PubMed=9050928; DOI=10.1007/s004390050377;
RA   Scartezzini P., Egeo A., Colella S., Fumagalli P., Arrigo P., Nizetic D.,
RA   Taramelli R., Rasore-Quartino A.;
RT   "Cloning a new human gene from chromosome 21q22.3 encoding a glutamic acid-
RT   rich protein expressed in heart and skeletal muscle.";
RL   Hum. Genet. 99:387-392(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-50.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP   GLU-23; ASN-50 AND ALA-188.
RC   TISSUE=Leiomyosarcoma, and Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       P55822; Q8IZD4: DCP1B; NbExp=2; IntAct=EBI-2654794, EBI-521595;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P55822-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P55822-2; Sequence=VSP_045788;
CC   -!- TISSUE SPECIFICITY: Expressed in heart and skeletal muscle.
CC   -!- SIMILARITY: Belongs to the SH3BGR family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-64 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; X93498; CAB57259.1; -; mRNA.
DR   EMBL; AL163279; CAB90456.1; -; Genomic_DNA.
DR   EMBL; AL163280; CAB90445.1; -; Genomic_DNA.
DR   EMBL; AF121781; AAD12067.1; -; Genomic_DNA.
DR   EMBL; AF121897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471079; EAX09638.1; -; Genomic_DNA.
DR   EMBL; CH471079; EAX09639.1; -; Genomic_DNA.
DR   EMBL; CH471079; EAX09640.1; -; Genomic_DNA.
DR   EMBL; BC006371; AAH06371.1; -; mRNA.
DR   EMBL; BM474020; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS33560.1; -. [P55822-2]
DR   RefSeq; NP_001001713.1; NM_001001713.1. [P55822-2]
DR   RefSeq; NP_001304671.1; NM_001317742.1. [P55822-2]
DR   RefSeq; NP_031367.2; NM_007341.3.
DR   AlphaFoldDB; P55822; -.
DR   SMR; P55822; -.
DR   BioGRID; 112348; 9.
DR   FunCoup; P55822; 341.
DR   IntAct; P55822; 5.
DR   STRING; 9606.ENSP00000332513; -.
DR   iPTMnet; P55822; -.
DR   PhosphoSitePlus; P55822; -.
DR   BioMuta; SH3BGR; -.
DR   DMDM; 215274184; -.
DR   MassIVE; P55822; -.
DR   PaxDb; 9606-ENSP00000332513; -.
DR   PeptideAtlas; P55822; -.
DR   ProteomicsDB; 56872; -. [P55822-1]
DR   ProteomicsDB; 883; -.
DR   Pumba; P55822; -.
DR   Antibodypedia; 23450; 197 antibodies from 30 providers.
DR   DNASU; 6450; -.
DR   Ensembl; ENST00000380631.5; ENSP00000370005.1; ENSG00000185437.17. [P55822-2]
DR   Ensembl; ENST00000380634.5; ENSP00000370008.1; ENSG00000185437.17. [P55822-2]
DR   Ensembl; ENST00000380637.7; ENSP00000370011.3; ENSG00000185437.17. [P55822-2]
DR   GeneID; 6450; -.
DR   KEGG; hsa:6450; -.
DR   UCSC; uc002yxz.4; human. [P55822-1]
DR   AGR; HGNC:10822; -.
DR   ClinPGx; PA35730; -.
DR   CTD; 6450; -.
DR   DisGeNET; 6450; -.
DR   GeneCards; SH3BGR; -.
DR   HGNC; HGNC:10822; SH3BGR.
DR   HPA; ENSG00000185437; Group enriched (skeletal muscle, tongue).
DR   MIM; 602230; gene.
DR   OpenTargets; ENSG00000185437; -.
DR   VEuPathDB; HostDB:ENSG00000185437; -.
DR   eggNOG; KOG4023; Eukaryota.
DR   GeneTree; ENSGT00940000159847; -.
DR   HOGENOM; CLU_084862_0_1_1; -.
DR   InParanoid; P55822; -.
DR   OMA; FNEKEYC; -.
DR   OrthoDB; 9932926at2759; -.
DR   PAN-GO; P55822; 1 GO annotation based on evolutionary models.
DR   PhylomeDB; P55822; -.
DR   PathwayCommons; P55822; -.
DR   SignaLink; P55822; -.
DR   Agora; ENSG00000185437; -.
DR   BioGRID-ORCS; 6450; 8 hits in 1153 CRISPR screens.
DR   GeneWiki; SH3BGR; -.
DR   GenomeRNAi; 6450; -.
DR   Pharos; P55822; Tbio.
DR   PRO; PR:P55822; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; P55822; protein.
DR   Bgee; ENSG00000185437; Expressed in gastrocnemius and 98 other cell types or tissues.
DR   ExpressionAtlas; P55822; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-ARBA.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR   CDD; cd03030; GRX_SH3BGR; 1.
DR   FunFam; 3.40.30.10:FF:000065; SH3 domain-binding glutamic acid-rich-like protein; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR006993; Glut_rich_SH3-bd.
DR   InterPro; IPR051033; SH3BGR.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR12232:SF1; SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN; 1.
DR   PANTHER; PTHR12232; SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN; 1.
DR   Pfam; PF04908; SH3BGR; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Proteomics identification; Reference proteome;
KW   SH3-binding.
FT   CHAIN           1..239
FT                   /note="SH3 domain-binding glutamic acid-rich protein"
FT                   /id="PRO_0000220743"
FT   REGION          159..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           124..130
FT                   /note="SH3-binding"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        167..185
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..239
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..111
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_045788"
FT   VARIANT         23
FT                   /note="D -> E (in dbSNP:rs11575939)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_057182"
FT   VARIANT         50
FT                   /note="D -> N (in dbSNP:rs6517549)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT                   /id="VAR_057183"
FT   VARIANT         188
FT                   /note="V -> A (in dbSNP:rs9974333)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_028233"
FT   CONFLICT        232
FT                   /note="E -> EE (in Ref. 4; BM474020)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   239 AA;  26086 MW;  BA57B1C8034D6BBC CRC64;
     MPLLLLGETE PLKLERDCRS PVDPWAAASP DLALACLCHC QDLSSGAFPD RGVLGGVLFP
     TVEMVIKVFV ATSSGSIAIR KKQQEVVGFL EANKIDFKEL DIAGDEDNRR WMRENVPGEK
     KPQNGIPLPP QIFNEEQYCG DFDSFFSAKE ENIIYSFLGL APPPDSKGSE KAEEGGETEA
     QKEGSEDVGN LPEAQEKNEE EGETATEETE EIAMEGAEGE AEEEEETAEG EEPGEDEDS
//