ID   Y4HA_SINFN              Reviewed;         367 AA.
AC   P55471;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   28-JAN-2026, entry version 140.
DE   RecName: Full=Putative ionic transporter y4hA;
GN   OrderedLocusNames=NGR_a03490; ORFNames=y4hA;
OS   Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OG   Plasmid sym pNGR234a.
OC   Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC   Hyphomicrobiales; Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=9163424; DOI=10.1038/387394a0;
RA   Freiberg C.A., Fellay R., Bairoch A., Broughton W.J., Rosenthal A.,
RA   Perret X.;
RT   "Molecular basis of symbiosis between Rhizobium and legumes.";
RL   Nature 387:394-401(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101917 / NGR234;
RX   PubMed=19376903; DOI=10.1128/aem.00515-09;
RA   Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA   Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA   Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA   Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT   "Rhizobium sp. strain NGR234 possesses a remarkable number of secretion
RT   systems.";
RL   Appl. Environ. Microbiol. 75:4035-4045(2009).
CC   -!- FUNCTION: Possible cation transporter.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. {ECO:0000305}.
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DR   EMBL; U00090; AAB91689.1; -; Genomic_DNA.
DR   RefSeq; WP_010875363.1; NC_000914.2.
DR   AlphaFoldDB; P55471; -.
DR   SMR; P55471; -.
DR   KEGG; rhi:NGR_a03490; -.
DR   PATRIC; fig|394.7.peg.357; -.
DR   eggNOG; COG0387; Bacteria.
DR   HOGENOM; CLU_050648_1_0_5; -.
DR   OrthoDB; 9787814at2; -.
DR   Proteomes; UP000001054; Plasmid pNGR234a.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015386; F:potassium:proton antiporter activity; IEA:TreeGrafter.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:TreeGrafter.
DR   InterPro; IPR052946; Alkaline_pH_Ca-Antiporter.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   NCBIfam; TIGR00846; caca2; 1.
DR   PANTHER; PTHR37958; SODIUM-POTASSIUM/PROTON ANTIPORTER CHAA; 1.
DR   PANTHER; PTHR37958:SF1; SODIUM-POTASSIUM_PROTON ANTIPORTER CHAA; 1.
DR   Pfam; PF01699; Na_Ca_ex; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Plasmid; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..367
FT                   /note="Putative ionic transporter y4hA"
FT                   /id="PRO_0000209508"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   367 AA;  38079 MW;  3AC0B829F2EFA2CB CRC64;
     MKSRLQVRSA HVPLWSWIIP LFGCVIAAMT LAHVLPERSV VLLLMSAGLL TGAVFASVHH
     AEILAARVGQ PSGAILLAVC VTIIEVAIIG SLMLSGAEGN EEVARDTVFA AVMIVLNGVI
     GLCLVLGGRR HREQSFQLNA ASAALAVLGT LATLSLVLPN FVTAGKPQQF AAIQLVVIGL
     VSVVLYGVFL FVQTVRHRDY FIDDEDAASP PATHETPRNP LAAGALLVLA LIAVILLAML
     LSYPLDSAVE ALGLPQAVVG VTIAGVVLLP EGITSVKAAL MNRLQNSINL VLGSALASIG
     VTIPVVAAIS VALGRDLALG LAPQNLIMLI LTLFVGTITL GTGRTTVLQG AVHLAIFTVF
     LLLSAIP
//