ID   CDN2B_RAT               Reviewed;         130 AA.
AC   P55272;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   04-NOV-2026, entry version 165.
DE   RecName: Full=Cyclin-dependent kinase 4 inhibitor B;
DE   AltName: Full=p14-INK4b;
DE   AltName: Full=p15-INK4b;
GN   Name=Cdkn2b; Synonyms=Ink4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7546221; DOI=10.1002/mc.2940140106;
RA   Hino O., Kobayashi E., Hirayama Y., Kobayashi T., Kubo Y., Tsuchiya H.,
RA   Kikuchi Y., Mitani H.;
RT   "Molecular genetic basis of renal carcinogenesis in the Eker rat model of
RT   tuberous sclerosis (Tsc2).";
RL   Mol. Carcinog. 14:23-27(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ACI/SegHsd, and COP; TISSUE=Lung;
RA   Buckles L.K., Shull J.D.;
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-86.
RX   PubMed=7712460;
RA   Knapek D.F., Serrano M., Beach D., Trono D., Walker C.L.;
RT   "Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney
RT   epithelial cell lines but not primary renal tumors.";
RL   Cancer Res. 55:1607-1612(1995).
CC   -!- FUNCTION: Interacts strongly with CDK4 and CDK6. Potent inhibitor.
CC       Potential effector of TGF-beta induced cell cycle arrest (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of CDKN2B with CDK4 or CDK6.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=Long;
CC         IsoId=P55272-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=P55272-2; Sequence=VSP_018702;
CC   -!- TISSUE SPECIFICITY: Expression abundant in lung, less abundant in
CC       testis, barely detectable in liver, and not detectable in neonatal
CC       kidney, adult kidney, brain, heart, or spleen.
CC   -!- SIMILARITY: Belongs to the CDKN2 cyclin-dependent kinase inhibitor
CC       family. {ECO:0000305}.
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DR   EMBL; S79760; AAB35360.1; -; mRNA.
DR   EMBL; AF474978; AAL76340.1; -; mRNA.
DR   EMBL; AF474979; AAL76341.1; -; mRNA.
DR   EMBL; S77734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_570825.1; NM_130812.5. [P55272-1]
DR   AlphaFoldDB; P55272; -.
DR   BMRB; P55272; -.
DR   SMR; P55272; -.
DR   FunCoup; P55272; 389.
DR   STRING; 10116.ENSRNOP00000008898; -.
DR   PhosphoSitePlus; P55272; -.
DR   PaxDb; 10116-ENSRNOP00000008898; -.
DR   DNASU; 25164; -.
DR   Ensembl; ENSRNOT00055029275; ENSRNOP00055023543; ENSRNOG00055017275. [P55272-1]
DR   Ensembl; ENSRNOT00060023935; ENSRNOP00060019060; ENSRNOG00060013978. [P55272-1]
DR   Ensembl; ENSRNOT00065032930; ENSRNOP00065026315; ENSRNOG00065019508. [P55272-1]
DR   GeneID; 25164; -.
DR   KEGG; rno:25164; -.
DR   UCSC; RGD:2324; rat. [P55272-1]
DR   AGR; RGD:2324; -.
DR   CTD; 1030; -.
DR   RGD; 2324; Cdkn2b.
DR   eggNOG; KOG0504; Eukaryota.
DR   InParanoid; P55272; -.
DR   OMA; AIQVMML; -.
DR   OrthoDB; 539213at2759; -.
DR   PhylomeDB; P55272; -.
DR   Reactome; R-RNO-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-RNO-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR   Reactome; R-RNO-2559585; Oncogene Induced Senescence.
DR   Reactome; R-RNO-69231; Cyclin D associated events in G1.
DR   PRO; PR:P55272; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; ISO:RGD.
DR   GO; GO:0019901; F:protein kinase binding; ISO:RGD.
DR   GO; GO:0071460; P:cellular response to cell-matrix adhesion; ISO:RGD.
DR   GO; GO:0031670; P:cellular response to nutrient; ISO:RGD.
DR   GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:RGD.
DR   GO; GO:0090398; P:cellular senescence; ISO:RGD.
DR   GO; GO:0001889; P:liver development; IEP:RGD.
DR   GO; GO:0030219; P:megakaryocyte differentiation; ISO:RGD.
DR   GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; IMP:RGD.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:RGD.
DR   GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:RGD.
DR   GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; ISO:RGD.
DR   GO; GO:0060253; P:negative regulation of glial cell proliferation; IMP:RGD.
DR   GO; GO:0030858; P:positive regulation of epithelial cell differentiation; IEP:RGD.
DR   GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
DR   GO; GO:0070316; P:regulation of G0 to G1 transition; ISO:RGD.
DR   GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0034097; P:response to cytokine; IEP:RGD.
DR   GO; GO:0048536; P:spleen development; ISO:RGD.
DR   GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISO:RGD.
DR   FunFam; 1.25.40.20:FF:000107; cyclin-dependent kinase 4 inhibitor B; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR050776; Ank_Repeat/CDKN_Inhibitor.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24201; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24201:SF8; CYCLIN-DEPENDENT KINASE 4 INHIBITOR B; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   Alternative initiation; ANK repeat; Cell cycle; Phosphoprotein;
KW   Reference proteome; Repeat; Tumor suppressor.
FT   CHAIN           1..130
FT                   /note="Cyclin-dependent kinase 4 inhibitor B"
FT                   /id="PRO_0000004808"
FT   REPEAT          5..34
FT                   /note="ANK 1"
FT   REPEAT          38..66
FT                   /note="ANK 2"
FT   REPEAT          71..100
FT                   /note="ANK 3"
FT   REPEAT          104..130
FT                   /note="ANK 4"
FT   MOD_RES         12
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P55271"
FT   VAR_SEQ         1..45
FT                   /note="Missing (in isoform Short)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_018702"
SQ   SEQUENCE   130 AA;  13749 MW;  AC45B21FA69FAD92 CRC64;
     MLGGGSDAGL ATAAARGQVE TVRQLLEAGA DPNAVNRFGR RPIQVMMMGS AQVAELLLLH
     GAEPNCADPA TLTRPVHDAA REGFLDTLMV LHKAGARLDV CDAWGRLPVD LAEEQGHRDI
     ARYLHAATGD
//