ID   INHBC_HUMAN             Reviewed;         352 AA.
AC   P55103; A1L3Y2;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   02-SEP-2026, entry version 180.
DE   RecName: Full=Inhibin beta C chain;
DE   AltName: Full=Activin beta-C chain;
DE   Flags: Precursor;
GN   Name=INHBC;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=7826378; DOI=10.1006/bbrc.1995.1086;
RA   Hoetten G., Neidhardt H., Schneider C., Pohl J.;
RT   "Cloning of a new member of the TGF-beta family: a putative new activin
RT   beta C chain.";
RL   Biochem. Biophys. Res. Commun. 206:608-613(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=9428386;
RX   DOI=10.1002/(sici)1097-0045(19980101)34:1<34::aid-pros5>3.0.co;2-k;
RA   Thomas T.Z., Chapman S.M., Hong W., Gurusingfhe C., Mellor S.L.,
RA   Fletcher R., Pedersen J., Risbridger G.P.;
RT   "Inhibins, activins, and follistatins: expression of mRNAs and cellular
RT   localization in tissues from men with benign prostatic hyperplasia.";
RL   Prostate 34:34-43(1998).
CC   -!- FUNCTION: Inhibins and activins inhibit and activate, respectively, the
CC       secretion of follitropin by the pituitary gland. Inhibins/activins are
CC       involved in regulating a number of diverse functions such as
CC       hypothalamic and pituitary hormone secretion, gonadal hormone
CC       secretion, germ cell development and maturation, erythroid
CC       differentiation, insulin secretion, nerve cell survival, embryonic
CC       axial development or bone growth, depending on their subunit
CC       composition. Inhibins appear to oppose the functions of activins.
CC   -!- SUBUNIT: Homodimeric or heterodimeric through association with alpha
CC       and beta subunits, linked by one or more disulfide bonds. Inhibins are
CC       heterodimers of one alpha and one beta subunit. Activins are homo- or
CC       heterodimers of beta subunits only (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in benign prostatic hyperplasia.
CC       {ECO:0000269|PubMed:9428386}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR   EMBL; X82540; CAA57890.1; -; mRNA.
DR   EMBL; CH471054; EAW97011.1; -; Genomic_DNA.
DR   EMBL; BC130324; AAI30325.1; -; mRNA.
DR   EMBL; BC130326; AAI30327.1; -; mRNA.
DR   CCDS; CCDS8938.1; -.
DR   PIR; JC2466; JC2466.
DR   RefSeq; NP_005529.1; NM_005538.4.
DR   AlphaFoldDB; P55103; -.
DR   SMR; P55103; -.
DR   FunCoup; P55103; 418.
DR   NDEx; IQUERY-CP-INHBC; 1 NDEx IQuery Curated Pathway.
DR   STRING; 9606.ENSP00000308716; -.
DR   GlyCosmos; P55103; 3 sites, No reported glycans.
DR   GlyGen; P55103; 4 sites, 1 O-linked glycan (1 site).
DR   iPTMnet; P55103; -.
DR   PhosphoSitePlus; P55103; -.
DR   BioMuta; INHBC; -.
DR   DMDM; 1708438; -.
DR   MassIVE; P55103; -.
DR   PaxDb; 9606-ENSP00000308716; -.
DR   PeptideAtlas; P55103; -.
DR   ProteomicsDB; 56791; -.
DR   Antibodypedia; 28599; 322 antibodies from 30 providers.
DR   DNASU; 3626; -.
DR   Ensembl; ENST00000309668.3; ENSP00000308716.2; ENSG00000175189.4.
DR   GeneID; 3626; -.
DR   KEGG; hsa:3626; -.
DR   MANE-Select; ENST00000309668.3; ENSP00000308716.2; NM_005538.4; NP_005529.1.
DR   UCSC; uc001snv.3; human.
DR   AGR; HGNC:6068; -.
DR   ClinPGx; PA29879; -.
DR   CTD; 3626; -.
DR   DisGeNET; 3626; -.
DR   GeneCards; INHBC; -.
DR   HGNC; HGNC:6068; INHBC.
DR   HPA; ENSG00000175189; Tissue enriched (liver).
DR   MIM; 601233; gene.
DR   OpenTargets; ENSG00000175189; -.
DR   VEuPathDB; HostDB:ENSG00000175189; -.
DR   eggNOG; KOG3900; Eukaryota.
DR   GeneTree; ENSGT00940000160065; -.
DR   HOGENOM; CLU_020515_5_0_1; -.
DR   InParanoid; P55103; -.
DR   OMA; GIDCQGG; -.
DR   OrthoDB; 6516235at2759; -.
DR   PAN-GO; P55103; 3 GO annotations based on evolutionary models.
DR   PhylomeDB; P55103; -.
DR   PathwayCommons; P55103; -.
DR   Reactome; R-HSA-209822; Glycoprotein hormones.
DR   SignaLink; P55103; -.
DR   Agora; ENSG00000175189; -.
DR   BioGRID-ORCS; 3626; 20 hits in 1146 CRISPR screens.
DR   GeneWiki; INHBC; -.
DR   GenomeRNAi; 3626; -.
DR   Pharos; P55103; Tbio.
DR   PRO; PR:P55103; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; P55103; protein.
DR   Bgee; ENSG00000175189; Expressed in right lobe of liver and 34 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; TAS:ProtInc.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0005160; F:transforming growth factor beta receptor binding; TAS:ProtInc.
DR   GO; GO:0007178; P:cell surface receptor protein serine/threonine kinase signaling pathway; IBA:GO_Central.
DR   CDD; cd19406; TGF_beta_INHBC_E; 1.
DR   FunFam; 2.10.90.10:FF:000005; Inhibin beta A chain; 1.
DR   FunFam; 2.60.120.970:FF:000022; Inhibin subunit beta C; 1.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001318; Inhibin_betaC.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR015615; TGF-beta-like.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF130; INHIBIN BETA C CHAIN; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   PRINTS; PR00672; INHIBINBC.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Hormone; Proteomics identification; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..236
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033730"
FT   CHAIN           237..352
FT                   /note="Inhibin beta C chain"
FT                   /id="PRO_0000033731"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        143
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        161
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        240..248
FT                   /evidence="ECO:0000250"
FT   DISULFID        247..317
FT                   /evidence="ECO:0000250"
FT   DISULFID        276..349
FT                   /evidence="ECO:0000250"
FT   DISULFID        280..351
FT                   /evidence="ECO:0000250"
FT   DISULFID        316
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   VARIANT         322
FT                   /note="R -> Q (in dbSNP:rs2229357)"
FT                   /id="VAR_024230"
SQ   SEQUENCE   352 AA;  38238 MW;  496476AD82562D3E CRC64;
     MTSSLLLAFL LLAPTTVATP RAGGQCPACG GPTLELESQR ELLLDLAKRS ILDKLHLTQR
     PTLNRPVSRA ALRTALQHLH GVPQGALLED NREQECEIIS FAETGLSTIN QTRLDFHFSS
     DRTAGDREVQ QASLMFFVQL PSNTTWTLKV RVLVLGPHNT NLTLATQYLL EVDASGWHQL
     PLGPEAQAAC SQGHLTLELV LEGQVAQSSV ILGGAAHRPF VAARVRVGGK HQIHRRGIDC
     QGGSRMCCRQ EFFVDFREIG WHDWIIQPEG YAMNFCIGQC PLHIAGMPGI AASFHTAVLN
     LLKANTAAGT TGGGSCCVPT ARRPLSLLYY DRDSNIVKTD IPDMVVEACG CS
//