ID   ACR5_CAEEL              Reviewed;         598 AA.
AC   P54246; Q3Y417;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   02-DEC-2020, sequence version 5.
DT   04-NOV-2026, entry version 170.
DE   RecName: Full=Acetylcholine receptor subunit alpha-type acr-5;
DE   Flags: Precursor;
GN   Name=acr-5 {ECO:0000312|WormBase:K03F8.2};
GN   ORFNames=K03F8.2 {ECO:0000312|WormBase:K03F8.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION.
RX   PubMed=23351035; DOI=10.1111/ejn.12099;
RA   Sellings L., Pereira S., Qian C., Dixon-McDougall T., Nowak C., Zhao B.,
RA   Tyndale R.F., van der Kooy D.;
RT   "Nicotine-motivated behavior in Caenorhabditis elegans requires the
RT   nicotinic acetylcholine receptor subunits acr-5 and acr-15.";
RL   Eur. J. Neurosci. 37:743-756(2013).
CC   -!- FUNCTION: Subunit of nicotinic acetylcholine receptor (nAChR)
CC       (PubMed:23351035). Involved in nAChR sensitivity to nicotine
CC       (PubMed:23351035). Modulates locomotion towards the drug nicotine
CC       (PubMed:23351035). {ECO:0000269|PubMed:23351035}.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       Acetylcholine receptor (TC 1.A.9.1) subfamily. {ECO:0000305}.
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DR   EMBL; BX284603; CCD63926.1; -; Genomic_DNA.
DR   PIR; T16546; T16546.
DR   RefSeq; NP_001367477.1; NM_001379767.1.
DR   AlphaFoldDB; P54246; -.
DR   SMR; P54246; -.
DR   FunCoup; P54246; 74.
DR   STRING; 6239.K03F8.2.1; -.
DR   TCDB; 1.A.9.1.5; the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.
DR   GlyCosmos; P54246; 6 sites, No reported glycans.
DR   PaxDb; 6239-K03F8.2.1; -.
DR   PeptideAtlas; P54246; -.
DR   EnsemblMetazoa; K03F8.2.1; K03F8.2.1; WBGene00000044.
DR   GeneID; 191596; -.
DR   KEGG; cel:CELE_K03F8.2; -.
DR   UCSC; K03F8.2; c. elegans.
DR   AGR; WB:WBGene00000044; -.
DR   CTD; 191596; -.
DR   WormBase; K03F8.2; CE54125; WBGene00000044; acr-5.
DR   eggNOG; KOG3645; Eukaryota.
DR   HOGENOM; CLU_018074_0_2_1; -.
DR   InParanoid; P54246; -.
DR   OMA; AIHGQKH; -.
DR   OrthoDB; 5816887at2759; -.
DR   PhylomeDB; P54246; -.
DR   Reactome; R-CEL-112314; Neurotransmitter receptors and postsynaptic signal transmission.
DR   Reactome; R-CEL-629594; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
DR   PRO; PR:P54246; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00000044; Expressed in larva and 2 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1902495; C:transmembrane transporter complex; IBA:GO_Central.
DR   GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
DR   GO; GO:0071316; P:cellular response to nicotine; IMP:UniProtKB.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0007271; P:synaptic transmission, cholinergic; IBA:GO_Central.
DR   CDD; cd18997; LGIC_ECD_nAChR; 1.
DR   CDD; cd19051; LGIC_TM_cation; 1.
DR   FunFam; 1.20.58.390:FF:000063; AcetylCholine Receptor; 1.
DR   FunFam; 2.70.170.10:FF:000031; AcetylCholine Receptor; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Ion channel; Ion transport;
KW   Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW   Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW   Transport.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..598
FT                   /note="Acetylcholine receptor subunit alpha-type acr-5"
FT                   /id="PRO_0000000402"
FT   TOPO_DOM        17..323
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        324..344
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        345..356
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        357..377
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        378..391
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        392..412
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        413..563
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        564..584
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        585..598
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        54
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        71
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        178
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        252
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   598 AA;  70234 MW;  9476C3C6EFE4257E CRC64;
     MLPNIILILL IRYCSCGAGS RVYEKYGKQV QLSPATTSSY REWYDSNREH STRNNTNVDD
     FQTQLKKSLE NTTAAYNATF MQELIEERQR YLEKLNEGQF INDQRRLVEE LLDPNYYEKT
     VHPKRDYTRP TRVNLSMSLY QILDVDEHMQ SIEVNVWMVQ HWYDEFLDWN PVDYGMINRT
     IVPYHQIWIP DTYLYNSEEL EQKKTESLMN AQLETGHWNQ KKDGAKVQLM FPAIYKLSCR
     MDVRWFPYDR QNCTFIISSW THDKQTIDYW PLSSTVNLGN MARNDEWEVI SFEFVRVEET
     FKCCTAPWVM LYAHLVIRRK PLYYMINLVV PTSIITIVAV TGFFTPTSSS SERDEKLYLG
     INTLLTMSVM MLMVCNQMPS TSTYVPLMSW YYIGIIMVIV VGTFLATGVL AIHGQKHYNK
     PISDRIRKLI YNPVVEFFIL SPPTSLIDLW TEFGVISEQR HSTHLDPLLL QHMDPISHTT
     RADPQHFFGS ISSQMCDLQS TYSYTARLAT ITRQYTQHAK MKALRKNQYR MSMDTSQARG
     VKKQKMQRRC SLEWEFLANV LDRILLTIFC GFTFAVFIIL IGFDSFFTFH TDSPPKTM
//