ID   CTHL5_BOVIN             Reviewed;         159 AA.
AC   P54229; A5PJ96; B9UKL6;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   04-NOV-2026, entry version 139.
DE   RecName: Full=Cathelicidin-5;
DE   AltName: Full=Antibacterial peptide BMAP-28;
DE   AltName: Full=Myeloid antibacterial peptide 28;
DE   Flags: Precursor;
GN   Name=CATHL5; Synonyms=BMAP28;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=8910461; DOI=10.1074/jbc.271.45.28375;
RA   Skerlavaj B., Gennaro R., Bagella L., Merluzzi L., Risso A., Zanetti M.;
RT   "Biological characterization of two novel cathelicidin-derived peptides and
RT   identification of structural requirements for their antimicrobial and cell
RT   lytic activities.";
RL   J. Biol. Chem. 271:28375-28381(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate 44, Isolate 74, and Isolate JEW38;
RX   PubMed=19136450; DOI=10.1093/jhered/esn112;
RA   Gillenwaters E.N., Seabury C.M., Elliott J.S., Womack J.E.;
RT   "Sequence analysis and polymorphism discovery in 4 members of the bovine
RT   cathelicidin gene family.";
RL   J. Hered. 100:241-245(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   CHARACTERIZATION.
RX   PubMed=8706679; DOI=10.1111/j.1432-1033.1996.0769w.x;
RA   Storici P., Tossi A., Lenarcic B., Romeo D.;
RT   "Purification and structural characterization of bovine cathelicidins,
RT   precursors of antimicrobial peptides.";
RL   Eur. J. Biochem. 238:769-776(1996).
CC   -!- FUNCTION: Exerts a potent antimicrobial activity against Gram-negative
CC       and Gram-positive bacteria, including methicillin-resistant
CC       Staphylococcus aureus, and fungi. {ECO:0000269|PubMed:8706679}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8706679}.
CC   -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR   EMBL; X97609; CAA66208.1; -; mRNA.
DR   EMBL; EU751296; ACI31918.1; -; Genomic_DNA.
DR   EMBL; EU751297; ACI31919.1; -; Genomic_DNA.
DR   EMBL; EU751302; ACI31924.1; -; Genomic_DNA.
DR   EMBL; BC142015; AAI42016.1; -; mRNA.
DR   RefSeq; NP_776935.1; NM_174510.3.
DR   PDB; 2NDC; NMR; -; A=132-149.
DR   PDB; 2NDE; NMR; -; A=132-149.
DR   AlphaFoldDB; P54229; -.
DR   SMR; P54229; -.
DR   FunCoup; P54229; 192.
DR   STRING; 9913.ENSBTAP00000017763; -.
DR   PaxDb; 9913-ENSBTAP00000017763; -.
DR   PeptideAtlas; P54229; -.
DR   GeneID; 282167; -.
DR   KEGG; bta:282167; -.
DR   CTD; 282167; -.
DR   eggNOG; ENOG502SAES; Eukaryota.
DR   HOGENOM; CLU_121724_1_1_1; -.
DR   InParanoid; P54229; -.
DR   OrthoDB; 9930485at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   FunFam; 3.10.450.10:FF:000003; Cathelicidin antimicrobial peptide; 1.
DR   Gene3D; 3.10.450.10; -; 1.
DR   InterPro; IPR001894; Cathelicidin-like.
DR   InterPro; IPR018216; Cathelicidin_CS.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR10206; CATHELICIDIN; 1.
DR   PANTHER; PTHR10206:SF2; CATHELICIDIN ANTIMICROBIAL PEPTIDE; 1.
DR   Pfam; PF00666; Cathelicidins; 1.
DR   SUPFAM; SSF54403; Cystatin/monellin; 1.
DR   PROSITE; PS00946; CATHELICIDINS_1; 1.
DR   PROSITE; PS00947; CATHELICIDINS_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Disulfide bond;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..131
FT                   /id="PRO_0000004716"
FT   PEPTIDE         132..159
FT                   /note="Cathelicidin-5"
FT                   /id="PRO_0000004717"
FT   MOD_RES         30
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:P19660"
FT   DISULFID        86..97
FT                   /evidence="ECO:0000250"
FT   DISULFID        108..125
FT                   /evidence="ECO:0000250"
FT   TURN            134..136
FT                   /evidence="ECO:0007829|PDB:2NDC"
FT   HELIX           137..143
FT                   /evidence="ECO:0007829|PDB:2NDC"
FT   TURN            146..148
FT                   /evidence="ECO:0007829|PDB:2NDE"
SQ   SEQUENCE   159 AA;  17616 MW;  89B7CB46C5EEC367 CRC64;
     METQRASLSL GRWSLWLLLL GLALPSASAQ ALSYREAVLR AVDQLNEKSS EANLYRLLEL
     DPPPKEDDEN PNIPKPVSFR VKETVCPRTS QQSPEQCDFK ENGLLKECVG TVTLDQVGSN
     FDITCAVPQS VGGLRSLGRK ILRAWKKYGP IIVPIIRIG
//