ID   AMT1_CAEEL              Reviewed;         534 AA.
AC   P54145;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   02-SEP-2026, entry version 134.
DE   RecName: Full=Putative ammonium transporter 1;
GN   Name=amt-1; ORFNames=C05E11.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Involved in the uptake of ammonia. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ammonia transporter channel (TC 1.A.11.2)
CC       family. {ECO:0000305}.
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DR   EMBL; FO080371; CCD63261.1; -; Genomic_DNA.
DR   PIR; T15414; T15414.
DR   RefSeq; NP_508784.1; NM_076383.5.
DR   AlphaFoldDB; P54145; -.
DR   SMR; P54145; -.
DR   FunCoup; P54145; 22.
DR   STRING; 6239.C05E11.4.1; -.
DR   PaxDb; 6239-C05E11.4.1; -.
DR   PeptideAtlas; P54145; -.
DR   EnsemblMetazoa; C05E11.4.1; C05E11.4.1; WBGene00000133.
DR   GeneID; 180729; -.
DR   KEGG; cel:CELE_C05E11.4; -.
DR   UCSC; C05E11.4; c. elegans.
DR   AGR; WB:WBGene00000133; -.
DR   CTD; 180729; -.
DR   WormBase; C05E11.4; CE06770; WBGene00000133; amt-1.
DR   eggNOG; KOG0682; Eukaryota.
DR   HOGENOM; CLU_000445_33_1_1; -.
DR   InParanoid; P54145; -.
DR   OMA; CGFAYLE; -.
DR   OrthoDB; 534912at2759; -.
DR   PhylomeDB; P54145; -.
DR   PRO; PR:P54145; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00000133; Expressed in larva and 1 other cell type or tissue.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008519; F:ammonium channel activity; IEA:InterPro.
DR   GO; GO:0097272; P:ammonium homeostasis; IBA:GO_Central.
DR   FunFam; 1.10.3430.10:FF:000010; Ammonium transporter; 1.
DR   Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR   InterPro; IPR029020; Ammonium/urea_transptr.
DR   InterPro; IPR001905; Ammonium_transpt.
DR   InterPro; IPR018047; Ammonium_transpt_CS.
DR   InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR   NCBIfam; TIGR00836; amt; 1.
DR   PANTHER; PTHR11730; AMMONIUM TRANSPORTER; 1.
DR   PANTHER; PTHR11730:SF118; AMMONIUM TRANSPORTER 1-RELATED; 1.
DR   Pfam; PF00909; Ammonium_transp; 1.
DR   SUPFAM; SSF111352; Ammonium transporter; 1.
DR   PROSITE; PS01219; AMMONIUM_TRANSP; 1.
PE   3: Inferred from homology;
KW   Ammonia transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..534
FT                   /note="Putative ammonium transporter 1"
FT                   /id="PRO_0000139751"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   534 AA;  58491 MW;  C17CFE44E0DC3D05 CRC64;
     MTTPTNFTTE IDKLHAEITR LETGFYENVN SFFLCSMALI IFFMQCGFAY LEAGAVRSKN
     TTNILIKNLL DSCICIIGYW AIGWALAYGD SGEGVNLFVG HSQFFLSGFS DYPRFFFQYV
     FSATAATIVS GAVAERCEFI TYVTYCTVIS TFIYPVLTHW GWTENGWMAK GITSGIIDTK
     YDDFAGSGLV HLCGGSISFL AAWIMGPRIG KFPDDEDDES DEILGHSVPF TALGGFILMF
     GFLAFNGGSV ASISHAGDGH TVALAMINTI LSGAFAALIY LGVHYYQHGK WTLLLTINAC
     LSGMVAACAG CNKMEPWACI WVGLGAGLIY LAFSKLMIRL KIDDPLDAFA VHAGGGFWGL
     MSSSIISHGG VAYALADAVS GAKNSGDHLT QAFAQLGWQM ICALAIIAWS LGVMLPIFWI
     LKKTGKLRVS EEVEINGLDV FKHGEMAYPL RAYGHGWHDF ERANKIQAFS AKITVGEGKN
     TRIMKIHPEM SIEQLASVYD RSGNIIPMPK KSRTLFTNSA ERKMSQMMYD ENKM
//