ID   SWT21_YEAST             Reviewed;         357 AA.
AC   P53873; D6W100;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   10-JUN-2026, entry version 150.
DE   RecName: Full=Protein SWT21;
DE   AltName: Full=Synthetic With TGS1 protein 21;
GN   Name=SWT21; OrderedLocusNames=YNL187W; ORFNames=N1615;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169873; DOI=10.1038/387s093;
RA   Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA   Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA   Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA   Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA   Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA   Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA   Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA   Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA   Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA   Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA   Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA   Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA   Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA   Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA   Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA   Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA   Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT   evolutionary implications.";
RL   Nature 387:93-98(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=15020406; DOI=10.1534/genetics.166.1.53;
RA   Murphy M.W., Olson B.L., Siliciano P.G.;
RT   "The yeast splicing factor Prp40p contains functional leucine-rich nuclear
RT   export signals that are essential for splicing.";
RL   Genetics 166:53-65(2004).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND ASSOCIATION WITH SNRNPS.
RX   PubMed=19451230; DOI=10.1128/mcb.00384-09;
RA   Hage R., Tung L., Du H., Stands L., Rosbash M., Chang T.H.;
RT   "A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p
RT   for stable U1 snRNP/Pre-mRNA interaction.";
RL   Mol. Cell. Biol. 29:3941-3952(2009).
CC   -!- FUNCTION: Involved in mRNA splicing. Helps to stabilize the U1 snRNP-5'
CC       splice site interaction. {ECO:0000269|PubMed:19451230}.
CC   -!- SUBUNIT: Associates with snRNPs.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15020406,
CC       ECO:0000269|PubMed:19451230}.
CC   -!- SIMILARITY: Belongs to the SWT21 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z71463; CAA96081.1; -; Genomic_DNA.
DR   EMBL; BK006947; DAA10366.1; -; Genomic_DNA.
DR   PIR; S63142; S63142.
DR   RefSeq; NP_014212.1; NM_001183025.1.
DR   AlphaFoldDB; P53873; -.
DR   SMR; P53873; -.
DR   BioGRID; 35646; 22.
DR   DIP; DIP-971N; -.
DR   FunCoup; P53873; 44.
DR   IntAct; P53873; 3.
DR   MINT; P53873; -.
DR   STRING; 4932.YNL187W; -.
DR   iPTMnet; P53873; -.
DR   PaxDb; 4932-YNL187W; -.
DR   PeptideAtlas; P53873; -.
DR   EnsemblFungi; YNL187W_mRNA; YNL187W; YNL187W.
DR   GeneID; 855534; -.
DR   KEGG; sce:YNL187W; -.
DR   AGR; SGD:S000005131; -.
DR   SGD; S000005131; SWT21.
DR   VEuPathDB; FungiDB:YNL187W; -.
DR   eggNOG; ENOG502QVPI; Eukaryota.
DR   HOGENOM; CLU_662333_0_0_1; -.
DR   InParanoid; P53873; -.
DR   OMA; VICQDIF; -.
DR   OrthoDB; 239865at2759; -.
DR   BioCyc; YEAST:G3O-33198-MONOMER; -.
DR   BioGRID-ORCS; 855534; 0 hits in 10 CRISPR screens.
DR   PRO; PR:P53873; -.
DR   Proteomes; UP000002311; Chromosome XIV.
DR   RNAct; P53873; protein.
DR   GO; GO:0005634; C:nucleus; IDA:SGD.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IMP:SGD.
DR   GO; GO:0000245; P:spliceosomal complex assembly; IMP:SGD.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR051150; SWT21/TCAB1_mRNA_Telomere.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13211; TELOMERASE CAJAL BODY PROTEIN 1; 1.
DR   PANTHER; PTHR13211:SF0; TELOMERASE CAJAL BODY PROTEIN 1; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome.
FT   CHAIN           1..357
FT                   /note="Protein SWT21"
FT                   /id="PRO_0000203403"
SQ   SEQUENCE   357 AA;  40308 MW;  ED52B00C4902453A CRC64;
     MEKKVICQDI FWSCDGTSFV SVHNDFGIRQ YLVPEESNTD KLNRNLLLPF TRFFRNQSIV
     SCAIDPFYTL YNENSDRLAG DRIVVGGKNF PLQLYSLMDG QCILSYDTMN KINGEYETVY
     SVKIDVESRV YTGSCRNKVA IYDKSRRDAV WMNQSTKKAS KGRQSIISCF EEQPMGGQAL
     SRGSLLCGSY ANEMFQVDCR HQRLERLNYT RTVAGGIVQI LTSDNGRYVY VVRRNSDAIS
     IYDRRNLQHE LNVLRLPFRI HHNSAKLKAY IDTAYGLSMG TPQGTILNWG RDLVEFGGVP
     SHNSVEDPLI TSIPPESEWR TNLDSTIPAT VVKNCPGDPE LFALSHGGTI SLCRFGG
//