ID   SCY1_YEAST              Reviewed;         804 AA.
AC   P53009; D6VU61;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   04-NOV-2026, entry version 174.
DE   RecName: Full=Protein kinase-like protein SCY1;
GN   Name=SCY1; OrderedLocusNames=YGL083W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Pietsch M., Gallwitz D.;
RL   Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9290212;
RX   DOI=10.1002/(sici)1097-0061(19970915)13:11<1077::aid-yea152>3.0.co;2-y;
RA   Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.;
RT   "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae
RT   chromosome VII.";
RL   Yeast 13:1077-1090(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169869; DOI=10.1038/387s081;
RA   Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA   Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA   Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA   Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA   Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA   Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA   Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA   Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA   Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA   Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA   Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA   Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA   Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA   Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA   Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA   Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA   Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA   Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA   Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA   Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA   Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA   Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL   Nature 387:81-84(1997).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC       inactive.
CC   -!- MISCELLANEOUS: Present with 1480 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; X97305; CAA65975.1; -; Genomic_DNA.
DR   EMBL; Z72605; CAA96788.1; -; Genomic_DNA.
DR   EMBL; BK006941; DAA08022.1; -; Genomic_DNA.
DR   PIR; S64090; S64090.
DR   RefSeq; NP_011432.1; NM_001180948.1.
DR   AlphaFoldDB; P53009; -.
DR   SMR; P53009; -.
DR   BioGRID; 33167; 58.
DR   DIP; DIP-4400N; -.
DR   FunCoup; P53009; 1031.
DR   IntAct; P53009; 2.
DR   STRING; 4932.YGL083W; -.
DR   GlyCosmos; P53009; 1 site, No reported glycans.
DR   GlyGen; P53009; 4 sites, 1 O-linked glycan (3 sites).
DR   iPTMnet; P53009; -.
DR   PaxDb; 4932-YGL083W; -.
DR   PeptideAtlas; P53009; -.
DR   EnsemblFungi; YGL083W_mRNA; YGL083W; YGL083W.
DR   GeneID; 852797; -.
DR   KEGG; sce:YGL083W; -.
DR   AGR; SGD:S000003051; -.
DR   SGD; S000003051; SCY1.
DR   VEuPathDB; FungiDB:YGL083W; -.
DR   eggNOG; KOG2137; Eukaryota.
DR   HOGENOM; CLU_008724_3_0_1; -.
DR   InParanoid; P53009; -.
DR   OMA; AACMCIL; -.
DR   OrthoDB; 79687at2759; -.
DR   BioCyc; YEAST:G3O-30584-MONOMER; -.
DR   BioGRID-ORCS; 852797; 2 hits in 13 CRISPR screens.
DR   PRO; PR:P53009; -.
DR   Proteomes; UP000002311; Chromosome VII.
DR   RNAct; P53009; protein.
DR   GO; GO:0005829; C:cytosol; HDA:SGD.
DR   GO; GO:0005759; C:mitochondrial matrix; IDA:SGD.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   CDD; cd14011; PK_SCY1_like; 1.
DR   FunFam; 1.10.510.10:FF:001116; Scy1p; 1.
DR   FunFam; 1.25.10.10:FF:001090; Scy1p; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR051177; CIK-Related_Protein.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   PANTHER; PTHR12984:SF6; SCY1-LIKE PROTEIN 2; 1.
DR   PANTHER; PTHR12984; SCY1-RELATED S/T PROTEIN KINASE-LIKE; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..804
FT                   /note="Protein kinase-like protein SCY1"
FT                   /id="PRO_0000097636"
FT   DOMAIN          1..324
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          666..804
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        667..685
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        701..729
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        744..759
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        760..776
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   804 AA;  91001 MW;  457A81DDC7AB808E CRC64;
     MMFWSSKTGI TSKYSFSSSP TFTAEPWSIY TGRPKSSSSS SPSKVSIFMF DKKQFENYLL
     HYGIIKSKSG SRDKVLIQEA YEILRNQANN LAKLKHPNIL TLIEPLEEHS KNFMFVTEFV
     TSSLETVFRE TDDEEQNFLQ GHVKDNIVVQ RGILQLVNAL DFVHNRASFV HLNIQPRAIF
     INENSDWKIS GLGYLVKIPP GTNTSEYFLP QYDPRVPPFM HLQLNYTAPE IVFENTLTFK
     NDYFSLGLLI YFLYTGKDLF RSENSTSEYK LEYNKFESKI STMSWDNIFS KVPQKLRHCI
     PKLINRDIYS RYDNITLILD SEFFQDPLVK TLNFLDDLPT KNNEEKYVFL EGLVNLLPEF
     PPALLQKKFL PILLELLSQF CAEKVVSDKC VGKSLDLIIK IGSTLSQLSF QEKVYPVLLS
     DANFPVLLKK ATICLIDNLD TLKQKVKRSD FLENILKPLF NYVLHDSESD ITVVCQEKLL
     SQIPLALEVL DFPTVKQFLL PLLSNLFTKT TSLTVKNTCV TCFQIMIEHK SIDSYTCSET
     VLPLFKSMKT RDPRILSKLL KLFETVPLII TDEIVLVDQV LPLMWNYSMA STLTKSQYSG
     YTKAINKMSS DIQKHHIAKL DDKVNDIGED AFHKVIEPTI MKKEDPETVA AKNIEVAAMQ
     PVKKKTGSSY GETLPQSKSI LNSKPLNPKN ALATRGFPTR ILNSPPQTPS SRTGSKVMTK
     GGSNDASSTK VEEEFNEFQS FSSTGSIRQT SAPSDVWMNS TPSPTPTSAS STNLPPGFSI
     SLQPNKRKDG SSDIPRSNVY GSLI
//