ID   HIS2_CERS4              Reviewed;         103 AA.
AC   P50935; Q3J488;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 2.
DT   04-NOV-2026, entry version 123.
DE   RecName: Full=Phosphoribosyl-ATP pyrophosphatase;
DE            Short=PRA-PH;
DE            EC=3.6.1.31;
GN   Name=hisE; OrderedLocusNames=RHOS4_08280; ORFNames=RSP_2241;
OS   Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
OS   31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC   Rhodobacterales; Paracoccaceae; Cereibacter.
OX   NCBI_TaxID=272943;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8760919; DOI=10.1099/13500872-142-8-2071;
RA   Oriol E., Mendez-Alvarez S., Barbe J., Gibert I.;
RT   "Cloning of the Rhodobacter sphaeroides hisL gene: unifunctionality of the
RT   encoded protein and lack of linkage to other his genes.";
RL   Microbiology 142:2071-2078(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC
RC   12203 / NCIMB 8253 / ATH 2.4.1.;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
RA   Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-
CC         ribosyl)-5'-AMP + diphosphate + H(+); Xref=Rhea:RHEA:22828,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:59457, ChEBI:CHEBI:73183; EC=3.6.1.31;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PRA-PH family. {ECO:0000305}.
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DR   EMBL; X87256; CAA60711.1; -; Genomic_DNA.
DR   EMBL; CP000143; ABA78396.1; -; Genomic_DNA.
DR   PIR; S54839; S54839.
DR   RefSeq; WP_011337341.1; NC_007493.2.
DR   AlphaFoldDB; P50935; -.
DR   SMR; P50935; -.
DR   STRING; 272943.RSP_2241; -.
DR   EnsemblBacteria; ABA78396; ABA78396; RSP_2241.
DR   GeneID; 3719771; -.
DR   GeneID; 48978803; -.
DR   KEGG; rsp:RSP_2241; -.
DR   PATRIC; fig|272943.9.peg.1144; -.
DR   eggNOG; COG0140; Bacteria.
DR   OMA; ADLFFHA; -.
DR   OrthoDB; 9814738at2; -.
DR   PhylomeDB; P50935; -.
DR   UniPathway; UPA00031; UER00007.
DR   Proteomes; UP000002703; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004636; F:phosphoribosyl-ATP diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000105; P:L-histidine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd11534; NTP-PPase_HisIE_like; 1.
DR   FunFam; 1.10.287.1080:FF:000002; Histidine biosynthesis bifunctional protein HisIE; 1.
DR   Gene3D; 1.10.287.1080; MazG-like; 1.
DR   HAMAP; MF_01020; HisE; 1.
DR   InterPro; IPR008179; HisE.
DR   InterPro; IPR021130; PRib-ATP_PPHydrolase-like.
DR   NCBIfam; TIGR03188; histidine_hisI; 1.
DR   NCBIfam; NF001611; PRK00400.1-3; 1.
DR   NCBIfam; NF001613; PRK00400.1-5; 1.
DR   PANTHER; PTHR42945; HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN; 1.
DR   PANTHER; PTHR42945:SF1; HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HIS7; 1.
DR   Pfam; PF01503; PRA-PH; 1.
DR   SUPFAM; SSF101386; all-alpha NTP pyrophosphatases; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Cytoplasm; Histidine biosynthesis;
KW   Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..103
FT                   /note="Phosphoribosyl-ATP pyrophosphatase"
FT                   /id="PRO_0000136386"
FT   CONFLICT        102
FT                   /note="R -> P (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   103 AA;  10900 MW;  912D942321EE45C8 CRC64;
     MTVLERLAAT VEARKGADPD SSWTAKLFAK GPEKCAEKFG EEAVEAIIEA VRGDRAKLAS
     EAADVLYHLL VMLAARDVTL AEVMAVLEAR EGTSGIAEKA GRG
//