ID   CHS1_BOTFU              Reviewed;         189 AA.
AC   P49603;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   02-SEP-2026, entry version 88.
DE   RecName: Full=Chitin synthase 1;
DE            EC=2.4.1.16;
DE   AltName: Full=Chitin-UDP acetyl-glucosaminyl transferase 1;
DE   AltName: Full=Class-I chitin synthase 1;
DE   Flags: Fragment;
GN   Name=chs1;
OS   Botrytis cinerea (Noble rot fungus) (Botryotinia fuckeliana).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Botrytis.
OX   NCBI_TaxID=40559;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SCHBC1;
RX   PubMed=7952170; DOI=10.1099/13500872-140-9-2199;
RA   Causier B.E., Milling R.J., Foster S.G., Adams D.J.;
RT   "Characterization of chitin synthase from Botrytis cinerea.";
RL   Microbiology 140:2199-2205(1994).
CC   -!- FUNCTION: Polymerizes chitin, a structural polymer of the cell wall and
CC       septum, by transferring the sugar moiety of UDP-GlcNAc to the non-
CC       reducing end of the growing chitin polymer. {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-
CC         D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP +
CC         H(+); Xref=Rhea:RHEA:16637, Rhea:RHEA-COMP:9593, Rhea:RHEA-COMP:9595,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17029, ChEBI:CHEBI:57705,
CC         ChEBI:CHEBI:58223; EC=2.4.1.16;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the chitin synthase family. Class I subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X77937; CAA54909.1; -; Genomic_DNA.
DR   PIR; S42870; S42870.
DR   AlphaFoldDB; P49603; -.
DR   SMR; P49603; -.
DR   PHI-base; PHI:276; -.
DR   GO; GO:0030428; C:cell septum; IEA:TreeGrafter.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004100; F:chitin synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006031; P:chitin biosynthetic process; IEA:TreeGrafter.
DR   InterPro; IPR004835; Chitin_synth.
DR   PANTHER; PTHR22914; CHITIN SYNTHASE; 1.
DR   PANTHER; PTHR22914:SF9; CHITIN SYNTHASE 1; 1.
DR   Pfam; PF01644; Chitin_synth_1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell wall biogenesis/degradation; Glycosyltransferase;
KW   Membrane; Transferase; Transmembrane.
FT   CHAIN           <1..>189
FT                   /note="Chitin synthase 1"
FT                   /id="PRO_0000193685"
FT   NON_TER         1
FT   NON_TER         189
SQ   SEQUENCE   189 AA;  21027 MW;  8106DF294AA06298 CRC64;
     DVLFARTMHG VFKNIEFMCT RKDSKTWGKD AWKKIVVCVV SDGRAKINPR TRAVLAGLGV
     YQDGIAKQQV NGKDVTAHIY EYTTQVGISL KKDIVTLTPK QQPVQLLFCL KEKNQKKINS
     HRWFFQAFGR VLDPNICVLL DAGTKPGKDS IYHLWKAFDL EPHCAGACGE IKAMLGPGGK
     NLVNPLVAT
//