ID MTR1A_CHICK Reviewed; 353 AA. AC P49285; DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1996, sequence version 1. DT 04-NOV-2026, entry version 147. DE RecName: Full=Melatonin receptor type 1A; DE Short=Mel-1A-R; DE Short=Mel1a receptor; DE AltName: Full=CKA; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; OC Phasianinae; Gallus. OX NCBI_TaxID=9031; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=7576645; DOI=10.1016/0896-6273(95)90090-x; RA Reppert S.M., Weaver D.R., Cassone V.M., Godson C., Kolakowski L.F. Jr.; RT "Melatonin receptors are for the birds: molecular analysis of two receptor RT subtypes differentially expressed in chick brain."; RL Neuron 15:1003-1015(1995). CC -!- FUNCTION: High affinity receptor for melatonin. The activity of this CC receptor is mediated by pertussis toxin sensitive G proteins that CC inhibits adenylate cyclase activity (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in optic tectum and retina, less in CC neostriatum, hypothalamus and thalamus. CC -!- SIMILARITY: Belongs to the G protein-coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U31820; AAA92498.1; -; mRNA. DR RefSeq; NP_990693.1; NM_205362.2. DR AlphaFoldDB; P49285; -. DR SMR; P49285; -. DR FunCoup; P49285; 139. DR STRING; 9031.ENSGALP00000022058; -. DR BindingDB; P49285; -. DR ChEMBL; CHEMBL2095154; -. DR DrugCentral; P49285; -. DR GlyCosmos; P49285; 2 sites, No reported glycans. DR GlyGen; P49285; 2 sites. DR PaxDb; 9031-ENSGALP00000022058; -. DR Ensembl; ENSGALT00010032089.1; ENSGALP00010018879.1; ENSGALG00010013336.1. DR GeneID; 396319; -. DR KEGG; gga:396319; -. DR CTD; 4543; -. DR VEuPathDB; HostDB:geneid_396319; -. DR eggNOG; KOG3656; Eukaryota. DR GeneTree; ENSGT00940000160321; -. DR HOGENOM; CLU_009579_3_3_1; -. DR InParanoid; P49285; -. DR OMA; AHCQISG; -. DR OrthoDB; 10044919at2759; -. DR PhylomeDB; P49285; -. DR Reactome; R-GGA-373076; Class A/1 (Rhodopsin-like receptors). DR Reactome; R-GGA-418594; G alpha (i) signalling events. DR PRO; PR:P49285; -. DR Proteomes; UP000000539; Chromosome 4. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0043235; C:signaling receptor complex; IEA:Ensembl. DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central. DR GO; GO:0042562; F:hormone binding; IEA:Ensembl. DR GO; GO:1904408; F:melatonin binding; IDA:AgBase. DR GO; GO:0008502; F:melatonin receptor activity; IEA:Ensembl. DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0046325; P:negative regulation of D-glucose import across plasma membrane; IDA:AgBase. DR GO; GO:0045820; P:negative regulation of glycolytic process; IDA:AgBase. DR CDD; cd15402; 7tmA_Mel1A; 1. DR FunFam; 1.20.1070.10:FF:000056; Melatonin receptor type 1A; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR002278; Mel_1A/1B_rcpt. DR InterPro; IPR000025; Melatonin_rcpt. DR PANTHER; PTHR24228; B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR; 1. DR PANTHER; PTHR24228:SF53; MELATONIN RECEPTOR TYPE 1A; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01149; MELATONIN1AR. DR PRINTS; PR00857; MELATONINR. DR SMART; SM01381; 7TM_GPCR_Srsx; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G protein-coupled receptor; Glycoprotein; KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..353 FT /note="Melatonin receptor type 1A" FT /id="PRO_0000069868" FT TOPO_DOM 1..32 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 33..53 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 54..66 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 67..87 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 88..105 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 106..126 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 127..145 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 146..166 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 167..190 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 191..211 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 212..243 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 244..264 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 265..277 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 278..298 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 299..353 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT REGION 1..26 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 4 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 9 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 103..180 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" SQ SEQUENCE 353 AA; 39896 MW; DBF078C7F2AF291D CRC64; MRANGSELNG TVLPRDPPAE GSPRRPPWVT STLATILIFT IVVDLLGNLL VILSVYRNKK LRNAGNIFVV SLAIADLVVA IYPYPLVLTS VFHNGWNLGY LHCQISGFLM GLSVIGSIFN ITGIAINRYC YICHSLKYDK LYSDKNSLCY VGLIWVLTVV AIVPNLFVGS LQYDPRIYSC TFAQSVSSAY TIAVVFFHFI LPIAIVTYCY LRIWILVIQV RRRVKPDNNP RLKPHDFRNF VTMFVVFVLF AVCWAPLNFI GLAVAVDPET IIPRIPEWLF VSSYYMAYFN SCLNAIIYGL LNQNFRREYK KIVVSFCTAK AFFQDSSNDA ADRIRSKPSP LITNNNQVKV DSV //