ID   CHSA_IPOPL              Reviewed;         362 AA.
AC   P48400;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   28-JAN-2026, entry version 86.
DE   RecName: Full=Chalcone synthase A;
DE            EC=2.3.1.74;
DE   AltName: Full=Naringenin-chalcone synthase A;
DE            Short=CHS-A;
DE   Flags: Fragment;
GN   Name=CHSA;
OS   Ipomoea platensis (Morning glory).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Convolvulaceae; Ipomoeeae; Ipomoea.
OX   NCBI_TaxID=35881;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7724563; DOI=10.1073/pnas.92.8.3338;
RA   Durbin M.L., Learn G.H., Huttley G.A., Clegg M.T.;
RT   "Evolution of the chalcone synthase gene family in the genus Ipomoea.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:3338-3342(1995).
CC   -!- FUNCTION: The primary product of this enzyme is 4,2',4',6'-
CC       tetrahydroxychalcone (also termed naringenin-chalcone or chalcone)
CC       which can under specific conditions spontaneously isomerize into
CC       naringenin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(E)-4-coumaroyl-CoA + 3 malonyl-CoA + 3 H(+) = 2',4,4',6'-
CC         tetrahydroxychalcone + 3 CO2 + 4 CoA; Xref=Rhea:RHEA:11128,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15413, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:85008; EC=2.3.1.74;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10023};
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; U15945; AAA62497.1; -; mRNA.
DR   AlphaFoldDB; P48400; -.
DR   SMR; P48400; -.
DR   UniPathway; UPA00154; -.
DR   GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:UniProtKB-ARBA.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0030639; P:polyketide biosynthetic process; IEA:TreeGrafter.
DR   CDD; cd00831; CHS_like; 1.
DR   FunFam; 3.40.47.10:FF:000014; Chalcone synthase 1; 1.
DR   FunFam; 3.40.47.10:FF:000025; Chalcone synthase 2; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877:SF104; CHALCONE SYNTHASE; 1.
DR   PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Flavonoid biosynthesis; Transferase.
FT   CHAIN           1..>362
FT                   /note="Chalcone synthase A"
FT                   /id="PRO_0000215996"
FT   ACT_SITE        168
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
FT   NON_TER         362
SQ   SEQUENCE   362 AA;  40434 MW;  9589BB9E159081EA CRC64;
     MSTTVLPDTW SRRAKRFEGH AKILAVGTAT PANWVDQTTY PDFYFRITNS EHLLEHKEKF
     RRICNKSKIR KRHLVLTEEL LKKNPNLCTY NETSLNTRQD TLVSEVPKLG KEAAMKAIKE
     WGRPISEITH LVFCTTSGVD MPGADFQLTK LLGLNISVKR LMMYQQGCNA GAAMLRLAKD
     LAENNKGARV LVVCSEVTLS VFRGPSLQQE DNLLAQCLFG DGSAAVIVGT DPRPGLETPL
     FELVSSAQTI IPDTDSHLKL HLLEMGLTFH CSKAVPSLIT QNVEDCLVKA FEPFGISDWN
     SIFWILHPGG NAILDRVEER LGLGPEKLRA SRDVLSEYGN LTSACVLFIL DLVRRKSKKQ
     QQ
//