ID   VAMP2_XENLA             Reviewed;         114 AA.
AC   P47193; Q5D065;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   02-SEP-2026, entry version 125.
DE   RecName: Full=Vesicle-associated membrane protein 2;
DE            Short=VAMP-2;
DE   AltName: Full=SYBII;
DE   AltName: Full=Synaptobrevin-2;
GN   Name=vamp2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wang X.-H., Poo M.-M.;
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 33-114.
RC   TISSUE=Embryo;
RX   PubMed=7601005; DOI=10.1242/dev.121.6.1927;
RA   Knecht A.K., Good P.J., Dawid I.B., Harland R.M.;
RT   "Dorsal-ventral patterning and differentiation of noggin-induced neural
RT   tissue in the absence of mesoderm.";
RL   Development 121:1927-1935(1995).
CC   -!- FUNCTION: Involved in the targeting and/or fusion of transport vesicles
CC       to their target membrane (By similarity). Major SNARE protein of
CC       synaptic vesicles which mediates fusion of synaptic vesicles to release
CC       neurotransmitters. Essential for fast vesicular exocytosis and
CC       activity-dependent neurotransmitter release as well as fast endocytosis
CC       that mediates rapid reuse of synaptic vesicles (By similarity).
CC       {ECO:0000250|UniProtKB:P63027, ECO:0000250|UniProtKB:P63044,
CC       ECO:0000250|UniProtKB:P63045}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle membrane {ECO:0000250|UniProtKB:P63027}; Single-pass type IV
CC       membrane protein {ECO:0000255}. Cell membrane
CC       {ECO:0000250|UniProtKB:P63045}.
CC   -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
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DR   EMBL; AF035017; AAB88138.1; -; mRNA.
DR   EMBL; BC060344; AAH60344.1; -; mRNA.
DR   EMBL; BC123114; AAI23115.1; -; mRNA.
DR   EMBL; U16801; AAA81376.1; -; mRNA.
DR   RefSeq; NP_001080944.1; NM_001087475.1.
DR   AlphaFoldDB; P47193; -.
DR   BMRB; P47193; -.
DR   SMR; P47193; -.
DR   DNASU; 394287; -.
DR   GeneID; 394287; -.
DR   KEGG; xla:394287; -.
DR   AGR; Xenbase:XB-GENE-5788238; -.
DR   CTD; 394287; -.
DR   Xenbase; XB-GENE-5788238; vamp2.L.
DR   OrthoDB; 10042941at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 394287; Expressed in brain and 20 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR   GO; GO:0017075; F:syntaxin-1 binding; IBA:GO_Central.
DR   GO; GO:0035493; P:SNARE complex assembly; IBA:GO_Central.
DR   GO; GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB.
DR   GO; GO:0016079; P:synaptic vesicle exocytosis; ISS:UniProtKB.
DR   GO; GO:0006906; P:vesicle fusion; ISS:UniProtKB.
DR   CDD; cd15870; R-SNARE_VAMP2; 1.
DR   FunFam; 1.20.5.110:FF:000013; Vesicle-associated membrane protein 2; 1.
DR   Gene3D; 1.20.5.110; -; 1.
DR   InterPro; IPR001388; Synaptobrevin-like.
DR   InterPro; IPR016444; Synaptobrevin/VAMP.
DR   InterPro; IPR042855; V_SNARE_CC.
DR   PANTHER; PTHR45701; SYNAPTOBREVIN FAMILY MEMBER; 1.
DR   Pfam; PF00957; Synaptobrevin; 1.
DR   PIRSF; PIRSF005409; Synaptobrevin_euk; 1.
DR   PRINTS; PR00219; SYNAPTOBREVN.
DR   SUPFAM; SSF58038; SNARE fusion complex; 1.
DR   PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR   PROSITE; PS50892; V_SNARE; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cell membrane; Coiled coil; Cytoplasmic vesicle; Membrane;
KW   Reference proteome; Synapse; Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..114
FT                   /note="Vesicle-associated membrane protein 2"
FT                   /id="PRO_0000206727"
FT   TOPO_DOM        2..92
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..111
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        112..114
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          29..89
FT                   /note="v-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..11
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   114 AA;  12473 MW;  AEF2EDDCDF2D1DBF CRC64;
     MSAPAAGPPA AAPGDGAPQG PPNLTSNRRL QQTQAQVDEV VDIMRVNVDK VLERDTKLSE
     LDDRADALQA GASQFETSAA KLKRKYWWKN MKMMIIMGVI CAIILIIIIV YFST
//